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111.
Michael Rosenzweig Douglas F. Marks Donna Hempel R. Paul Johnson 《Journal of medical primatology》1996,25(3):192-200
Abstract: Stable introduction of therapeutic genes into hematopoietic stem cells has the potential to reconstitute immunity in individuals with HIV infection. However, many important questions regarding the safety and efficacy of this approach remain unanswered and may be addressed in a non-human primate model. To facilitate evaluation of expression of foreign genes in T cells derived from transduced hematopoietic progenitor cells, we have established a culture system that supports the differentiation of rhesus macaque and human CD34+ bone marrow derived cells into mature T cells. Thymic stromal monolayers were prepared from the adherent cell fraction of collagenase digested fetal or neonatal thymus. After 10–14 days, purified rhesus CD34+ bone marrow-derived cells cultured on thymic stromal monolayers yielded CD3+CD4+CD8+, CD3+CD4+CD8?, and CD3+CD4?CD8+ cells. Following stimulation with mitogens, these T cells derived from CD34+ cells could be expanded over 1,000-fold and maintained in culture for up to 20 weeks. We next evaluated the ability of rhesus CD34+ cells transduced with a retroviral vector containing the marker gene neo to undergo in vitro T cell differentiation. CD34+ cells transduced in the presence of bone marrow stroma and then cultured on rhesus thymic stroma resulted in T cells containing the retroviral marker gene. These studies should facilitate both in vitro and in vivo studies of hematopoietic stem cell therapeutic strategies for AIDS. 相似文献
112.
We describe the activity patterns and time budget of a feral group of lion-tailed macaques that were confined to a disturbed
forest fragment of 65 ha and compare the results with those obtained for groups in protected forests. The degraded nature
of the study site was reflected in low tree densities, low specific diversity, gaps in the girth distribution of trees, and
frequent disturbance by humans. The study group of 43 subjects was twice as large as lion-tailed macaque groups in protected
habitats. They spent the most time ranging (34.0%), followed by foraging (23.7%), feeding (17.9%), resting (16.0%), and other
activities such as social interactions (8.4%). Monthly variations are significant for all activity categories except ranging.
Times spent resting and foraging are negatively correlated (r = −0.5) and show significant seasonal differences. Foraging time was highest from September to November, when key food sources such
asCullenia andArtocarpus were absent or marginally available. The study group spent most time (40.4%) at canopy levels between 21 and 30 m. They spent
more time each day ranging than resting or feeding and more time terrestrially compared with groups in protected forests.
Large group size, poor habitat quality, and seasonal variation in food availability were the major variables affecting their
time budget, and these variables accounted for differences from the time budgets of groups in protected forests. 相似文献
113.
Hideshi Ogawa 《International journal of primatology》1995,16(5):707-729
I describe bridging behavior and social relationships between adult males and infants in a free- ranging group of Tibetan
macaques (Macaca thibetana)at Mt. Huangshan, China. The subjects performed bridging in which two adult males simultaneously lifted up an infant, sucked
or touched its genitalia, and then groomed each other in nonagonistic contexts. Males also expressed social behaviors with
other males, such as mounting, penis-sucking, and embracing while touching each other’s penes. Males also employ bridging
while exploiting an infant as a social tool, not only to reduce the probability of an aggressive response from dominant males
(agonistic buffering), but also to develop and to maintain affiliative social relationships with other males. Use of male
infants in bridging contributed to frequent male-infant interactions such as holding,grooming, and penis-sucking. Although these interactions might not have a positive influence on infant survival, they may
facilitate the maintenance of affiliative relationships with adult males until they reach maturity. The development of bridging
might have a close relation to the high socionomic sex ratio (adult male/adult female) and frequent affiliative interactions
between males, especially among the adolescents and adults. 相似文献
114.
Septicemia in an Indian Rhesus Macaque (Macaca mulatta) associated with Providencia stuartii 下载免费PDF全文
David X. Liu Peter J. Didier Gail Plauche Bapi Pahar 《Journal of medical primatology》2016,45(6):330-332
Providencia stuartii (P. stuartii) is an opportunistic pathogen and major concern in urinary catheter‐related infections in human medicine. Here we report P. stuartii‐induced septicemia in an eighteen‐year‐old, female India‐origin Rhesus macaque with multiple traumatic wounds. The animal had neutrophilic leukocytosis, necrosuppurative meningoencephalitis, hypophysitis and bronchopneumonia with vasculitis, thrombosis, and clusters of extracellular Gram‐negative bacilli. P. stuartii was isolated from the lesions of the brain and lung and confirmed by PCR and sequencing. To the authors’ knowledge, this is the first case of septicemia associated with P. stuartii in a non‐human primate. 相似文献
115.
Osamu Takenaka Mika Hotta Akiko Takenaka Yoshi Kawamoto Bambang Suryobroto Edy Brotoisworo 《Primates; journal of primatology》1987,28(1):87-98
The monkeys on the island of Sulawesi (Celebes), Indonesia, comprise seven species ofMacaca, that isM. maura, M. tonkeana, M. hecki, M. nigrescens, M. nigra, M. ochreata, andM. brunnescens. Hemoglobins from 248 individuals of these seven species were analyzed by isoelectric focusing electrophoresis (IEFE) and
by starch gel electrophoresis in the presence of urea (USGE). Eighteen phenotypes consisting of eight molecular types were
identified by IEFE analysis. The speciestonkeana inhabiting the central part of the island revealed 11 phenotypes, while peripheral species such asnigrescens andbrunnescens carried only 3 and 2 phenotypes, respectively.
On USGE, three α chains and three β chains were identified and named α1, α2, and α6, and β1, β3, and β5, respectively. The
α1 chain has the same mobility as the α chains of other macaques, while the α2 chain is less positively charged than α1, and
α6 is the least positive among these α chains. The α2 chain is widely distributed in the Sulawesi macaques as the major component.
Four species,ochreata, tonkeana, maura, andnigrescens, carried the α1 and α6 chains as minor components. The electrophoretic mobility of β1 was the same as that of other macaques,
while β3 and β5 were more positively charged and less positively charged than β1, respectively. All of the Sulawesi species
had β3 in high or low gene frequencies and inmaura, tonkeana, andbrunnescens, this type was most abundant. β5 chain existed in the species of the northern peninsula, as the major type. The subordinate
type was β3 innigra andnigrescens and β1 inhecki. On the other hand, β1 was most frequently observed inochreata. 相似文献
116.
Takayoshi Shotake Ken Nozawa Charles Santiapilai 《Primates; journal of primatology》1991,32(3):283-299
Genetic variability within and between the troops of toque macaque in Sri Lanka was studied from a population genetical perspective.
Studies were made using electrophoretical blood protein variations as markers in order to clarify the genetic characteristics
of the population of this species. A total of 256 samples from 20 troops which were collected in the field in 1981 to 1982
and 1983 to 1984 were examined for 32 blood protein loci. Eleven loci, that is, Tf, Alb, TBPA, Hb-α, PHI, PGM-II, CA-I, IDH,
AK, ADA, and Ch-E showed the polymorphism in one or more troops. Of these 11 loci, 7 loci, that is, Tf, TBPA, Hb-α, PHI, PGM-II,
CA-I, and IDH were highly polymorphic in most troops. The genetic variability within troops were quantified as H=0.0782 in
average and this value was on higher level than other primates and comparable with that of continental macaques,Macaca fascicularis, in Thailand. The genetic differentiation between troops was quantified byG
ST
andF
ST
and these values were relatively smaller than those of other insular macaques. 相似文献
117.
E Behboodi D F Katz S J Samuels L Tell A G Hendrickx B L Lasley 《Journal of medical primatology》1991,20(5):229-234
Forty-four female cynomolgus macaques (Macaca fascicularis) were examined to determine the optimum fertile period for mating. Daily urinary estrone conjugates (E1C) were measured, beginning on day 7 of the menstrual cycle, until a 1.5-gold E1C rise above the baseline was detected. The females were bred the next morning. Pregnancies were verified in all animals at day 18 postbreeding, and/or on day 25 postbreeding. Serum progesterone levels were used to correlate the relationship between ovulation and the E1C peak. Forty-four of the 57 cycles indicated a urinary E1C peak between days 10-15 of the menstrual cycle; this peak occurred on the day following the initial 1.5-fold to twofold rise in 90% of the cycles. A single 2-hr mating period the day before, the day of, or the day after the E1C peak resulted in conception in 17 of 44 (38.6%) animals. 相似文献
118.
L Newell-Morris B Carrol A Covey S Medley G P Sackett 《Journal of medical primatology》1991,20(1):17-22
The growth and skeletal maturation of nine preterm female pigtailed macaques (Macaca nemestrina) obtained by C-section at less than or equal to 155 postconceptional days were followed through six months of age. At C-section they were of normal size and maturation for gestational age. Compared with 50 normal females born at term (mean = 173 +/- 6.4 postconceptional days), preterm infants were also of normal size at term, but delayed in skeletal maturation, requiring about one month to achieve the standard. 相似文献
119.
Normal serum values for alkaline phosphatase were significantly higher in juvenile male cynomolgus monkeys compared to adults. Conversely, blood urea nitrogen (BUN) was significantly lower in juveniles than adults. A comparison of selected EKG parameters from each group revealed no significant differences; however, there was a trend towards mean left axis deviation in adult animals. 相似文献
120.
Primaquine phosphate treatment (0.5 mg/kg/day, per os [p.o.], 14 days) significantly increased values for serum sodium, potassium, and uric acid, while calcium levels were decreased in male Macaca fascicularis. Serum values returned to baseline (pretreatment) levels by 30 days following primaquine treatment. 相似文献