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41.
42.
A. Singh A.S. Sekhon P. Unger M. Babb Y. Yang M. Michael 《Journal of applied microbiology》2021,130(4):1092-1105
43.
The persistent use of MLCs through VMAT and IMRT is causing additional wear and tear on these mechanical parts, leading to an increase in MLC interlocks, breakdowns and failures. This study investigates the effect of an MLC clean and service procedure on MLC performance and positional accuracy demonstrated through in-house service logbook reports, Varian MLC backlash test results, daily MLC position QC results and Varian TrueBeam trajectory log file data.A service and clean of each individual MLC leaf was carried out on 3 standard MLC and 2 high definition MLC (HDMLC) Varian TrueBeam linacs. In-house service logbook reports, Varian backlash test results, daily MLC picket fence QC results and beam hold data from patient delivery trajectory log files were analysed for up to 6 months pre and 2 years post the MLC service/clean to assess the impact on unplanned MLC maintenance work and MLC performance.The median (range) of hardware faults reduced from 12 (1–17) pre clean to 0 (0–1) and 4 (1–11) at 12 and 24 months respectively for all linacs with the exception of a HDMLC linac where faults increased from 4 pre-clean to 13 and 20 again at 12 and 24 months respectively. The reduction in faults in the alternative 4 linacs was consistent with the reduction in the number of MLCs reaching the 0.3 mm and the 0.4 mm backlash recommendations in the first 12 and 24 months following the service/clean. The increase in faults in the HDMLC linac was also consistent with the increase in MLCs reaching the 0.3 mm backlash recommendation in the first 12 and 24 months. The median (range) of MLCs reaching a daily picket fence QC position tolerance of 0.25 mm reduced from 14 (1–40) pre clean to 0 (0) at both 12 and 24 months post-clean. This demonstrates the improvement in MLC performance caused by the MLC service/clean but also reveals factors other than MLC position accuracy influence hardware faults. Additionally, the number of beam hold-offs determined from patient delivery trajectory log files were found to have no correlation with the MLC service/clean.The MLC service/clean improves MLC performance and MLC position accuracy, reducing reactive repair work for engineering and physics staff. The results were maintained for 1 year post the MLC service/clean, with a trend back towards pre-clean levels in the subsequent 12–24 months. This suggests this preventative maintenance work could be performed at a frequency of > 2 years. This period of reduced faults and improved performance is significant given the 10 year expected lifespan of a linac. 相似文献
44.
G. Sager 《Biometrical journal. Biometrische Zeitschrift》1983,25(5):477-490
Models of human height and weight growth and their interrelations are applied to the height/weight tables for British children given by Tanner, Whitehouse and Takaishi (1966) in two elaborate papers. Approximations using nonlinear regressions yield very satisfying results for height/age and log weight/height relations as well as the velocities of height and weight. Graphs with the basic data and the approximated growth curves are added. 相似文献
45.
46.
Aim Estimates of abundances and densities of birds and mammals have often been shown to be scale dependent, in that population sizes over large areas are overestimated if extrapolated from surveys of small plots. Previous tests of the mechanisms suggested to cause this decelerating scaling pattern found evidence of a biased choice of small plots in patches of homogeneous habitat. Here we show that negative density–area relationships can also arise as result of not considering plots where individuals of the species or assemblage of interest are absent in surveys of differing spatial resolution. Location We took a complete census of violets (Viola spp.) in 800 m2 of chalk grassland in Wye, Kent, UK, and used human population censuses for Finnish, Swiss and Italian municipalities, English districts, states of the USA and European countries. Methods We used mixed models of logarithmically transformed number of individuals or densities as a function of area. Results The census of violets shows that by increasing the survey resolution and by not considering plots without individuals, the effectively occupied area diminishes and a negative density–area relationship arises. The finding that negative density–area relationships are also common for people is evidence that the non‐random choice of plots in population surveys of varying areas can be responsible for many observed negative density–area relationships. The shallower slope of the people–administrative area relationship for Switzerland and Finland compared with Italy, as well as for England and the USA compared with Europe, confirms that less than proportionate individuals–area relationships can be the consequence of larger plot areas containing a higher proportion of areas without individuals. Main conclusions Densities should be reported together with the effective areas for which they were estimated. It should be clearly conveyed whether or not plots where the surveyed species was absent were included in the density estimation. 相似文献
47.
Examination of dispersional characteristics of Pratylenchus scribneri and Hoplolaimus galeatus indicated that there were patches within soybean fields in which both survival and reproduction wexe enhanced in spite of apparent homogeneity of soil type and topography. Treatment with carbofuran reduced the patchiness (or increased the dispersion) for H. galeatus while it had the opposite effect for P. scribneri. P. scribneri was less highly dispersed in conventional tillage plots than in the zero tillage plots. Populations from quadrats contained entirely within the patches could be described by the normal distribution (in the case of P. scribneri) or by the Poisson distribution (in the case of H. galeatus), while populations from quadrats contained entirely outside the patches could be described by the Poisson distribution for both nematodes. None of the distributions tested (Poisson, normal, negative binomial, Neyman''s) gave an adequate fit when populations from both inside and outside the patches were considered together. In all instances, log₁₀ and ln transformations reduced the goodness of fit of the data to all of the distributions tested. Even with logarithmic transformations, parametric statistics were not appropriate for analysis of data in most instances. 相似文献
48.
The development of SO42- influx in roots and sulfur transport to shoots was followed in 35S-tracer experiments for sulfur-deficient spring wheat (Triticum aestivum L. cv. Svenno) seedlings pretreated for various time periods (0–24 h) in nutrient solutions with SO42-. Effects of the metabolic inhibitor 2,4-dinitrophenol (DNP) and the protein synthesis inhibitor cycloheximide (CH) on SO42- influx were also evaluated. The SO42- influx appears feedback-regulated by the internal sulfur level of the roots. Regulation may be achieved solely by a rapidly changed SO42- carrier activity through an allosteric effect by the intracellular SO42- concentration of the roots, followed first by induction of carrier synthesis and then by repression of carrier synthesis after transfer of the roots from SO42--deficient nutrient solutions to solutions with SO42-. A Hill plot of the partly sigmoidal relationship between SO42- influx and intracellular sulfur concentration in the roots gave a Hill coefficient of -4.2, indicating negative cooperativity between a minimum number of four interacting allosteric binding sites for sulfur on each carrier entity. DNP-experiments showed that SO42- influx was mainly metabolic, especially after short pretreatment in SO42- at an external SO42- concentration of 0.1 mM. Pretreatment with CH rapidly prevented new SO42- carriers from being formed. Long CH pretreatment (24 h) and different SO42- pretreatments reduced SO42- influx below the non-metabolic level obtained by uptake experiments with DNP, indicating the existence of SO42- carriers mediating passive SO42- transport across the plasmalemma of the root cells. SO42- influx was further decreased for the CH pretreated (24 h) plants by the presence of both CH and DNP in the experimental nutrient solution. This probably indicates the diffusive part of the non-metabolic SO42- influx in the present experiments. Finally, it is suggested that there is a feedback signal between root and shoot, regulating sulfur transport upwards. 相似文献
49.
One goal of human microbiome studies is to relate host traits with human microbiome compositions. The analysis of microbial community sequencing data presents great statistical challenges, especially when the samples have different library sizes and the data are overdispersed with many zeros. To address these challenges, we introduce a new statistical framework, called predictive analysis in metagenomics via inverse regression (PAMIR), to analyze microbiome sequencing data. Within this framework, an inverse regression model is developed for overdispersed microbiota counts given the trait, and then a prediction rule is constructed by taking advantage of the dimension‐reduction structure in the model. An efficient Monte Carlo expectation‐maximization algorithm is proposed for maximum likelihood estimation. The method is further generalized to accommodate other types of covariates. We demonstrate the advantages of PAMIR through simulations and two real data examples. 相似文献
50.