排序方式: 共有25条查询结果,搜索用时 15 毫秒
21.
Isadora Reis Restier Pinheiro Marina Fátima Nunes Melo Sarah Vivas de Sousa Bárbara Gatti Cardoso Thaís Marques da Silva Luciana Pereira Rangel Vanessa Faria Cortes Hérica de Lima Santos Valéria Ernestânia Chaves Israel José Pereira Garcia Leandro Augusto Barbosa 《Journal of cellular biochemistry》2019,120(11):19052-19063
In this study, renal tissue, subdivided into the cortex and medulla of Wistar rats subjected to a cafeteria diet (CAF) for 24 days or to normal diet, was used to analyze whether the renal enzyme Na,K-ATPase activity was modified by CAF diet, as well as to analyze the α1 subunit of renal Na,K-ATPase expression levels. The lipid profile of the renal plasma membrane and oxidative stress were verified. In the Na,K-ATPase activity evaluation, no alteration was found, but a significant decrease of 30% in the cortex was detected in the α1 subunit expression of the enzyme. There was a 24% decrease in phospholipids in the cortex of rats submitted to CAF, a 17% increase in cholesterol levels in the cortex, and a 23% decrease in the medulla. Lipid peroxidation was significantly increased in the groups submitted to CAF, both in the cortical region, 29%, and in the medulla, 35%. Also, a reduction of 45% in the glutathione levels was observed in the cortex and medulla with CAF. CAF showed a nearly two-fold increase in glutathione peroxidase (GPX) activity in relation to the control group in the cortex and a 59% increase in the GPx activity in the medulla. In conclusion, although the diet was administered for a short period of time, important results were found, especially those related to the lipid profile and oxidative stress, which may directly affect renal function. 相似文献
22.
Laura K. Hilton 《Biochemical and biophysical research communications》2009,389(1):52-114
Mutations in NEK1 in mice are causal for cystic kidneys, and model the ciliopathy polycystic kidney disease caused by abnormal ciliary structure or signaling. NEK1 has previously been shown to localize near centrosomes and to play a role in centrosomal stability and ciliogenesis. Recent data suggest that the etiology of kidney cysts involves aberrant signaling from the primary cilium to the nucleus. Here we demonstrate that NEK1 contains functional nuclear localization signals, is exported from the nucleus via a nuclear export signal-dependent pathway and that the protein cycles through the nucleus. Our data suggest that NEK1 is a candidate to transduce messages from the ciliary-basal body region to the regulation of nuclear gene expression. 相似文献
23.
Jadwiga Chmielnicka Marenna Nasiadek Elżbieta Lewandowska-Zyndul 《Biological trace element research》1994,40(2):127-136
Certain disturbances in heme biosynthesis induced by aluminum chloride were examined. The experiment was performed on female
rats that received AlCl3 orally at the dose 100 mg Al/kg daily for 21 d. The effects of aluminum on the activity of delta-aminolevulinic acid synthetase
(ALA-S), dehydratase (ALA-D), and heme oxygenase (O.H.) were observed on 3, 7, 14, and 21 d in liver and kidneys of rats.
Also the activity of ALA-D in blood and the concentration of delta-aminolevulinic acid (ALA-U) in urine were observed. Orally
administered aluminum caused increase in the activity of ALA-D in the liver and blood, and parallel decrease of ALA-U in urine
(r=−0.85) of rats. Aluminum chloride also induced an increase of ALA-S and O.H. in the liver but not in the kidneys. The changes
of the enzymes activity participating in heme biosynthesis after administration of aluminum may be correlated with anemia
and iron metabolism in rats. 相似文献
24.
《Current biology : CB》2021,31(16):3629-3638.e2
- Download : Download high-res image (158KB)
- Download : Download full-size image
25.
Jiří Pařízek Jana Kalousková Ladislav Pavlík Miroslav Stýblo 《Biological trace element research》1992,34(3):257-263
The metabolism of trimethylselenonium ions (TMSe) was studied in male and female rats during maturation. Selenium (Se) retention
in the whole body as well as in organs was found to be significantly higher in male rats than in female a few hours after
parenteral administration of TMSe. The pronounced Se accumulation was observed in male kidneys. This sex-linked difference
was dependent on the presence of gonades and started to be manifested with sexual maturation during the third decade of postnatal
life. The effects of steroid hormones on the retention of Se from TMSe were examined in female and castrated male rats. The
results indicate that TMSe metabolism in rat kidneys may be influenced by androgen steroids. 相似文献