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51.
Electrophoretic light scattering (laser Doppler electrophoresis) has been employed to study the effects of guinea pig IgG
immune complexes on the electrophoretic mobility distributions of guinea pig resident peritoneal cells. The resident population
of cells is composed of macrophages (approximately 75%) and eosinophils (approximately 25%). These cells were separated according
to the well-established method of Boyum. Populations of resident macrophages, eosinophils, and the unfractionated samples
were incubated with soluble immune complexes, antigen alone, or antibody alone. The mean mobility of the resident macrophages
decreased approximately 60% when incubated in the presence of immune complexes, although no effect could be discerned in the
presence of antigen or antibody alone. The width of the resulting macrophage mobility distribution was larger than that of
the control distributions, with a broad shoulder on the high-mobility side, indicating a heterogeneous response of the macrophages
to the immune complexes. Eosinophils react in two distinct fashions. One population of eosinophils is present near the control
experiments. The second population reacts in a manner very similar to that of macrophages. This suggest that at least two
populations of eosinophils are present in the unstimulated guinea pig peritoneal cavity. Results that are intermediate between
these two cases are found when unfractionated samples are studied. 相似文献
52.
MASAMICHI AIKAWA ALAN H. COCHRANE RUTH S. NUSSENZWEIG JOHN RABBEGE 《The Journal of eukaryotic microbiology》1979,26(2):273-279
Plasmodium cynomolgi, Plasmodium knowlesi, and Plasmodium berghei sporozoites, before and after incubation with immune serum, were studied after freeze-fracture by electron microscopy. There were evenly distributed numerous intramembranous particles (IMP) on the P face of the outer membrane. The E face of the plasma membrane had fewer IMP than its P face. The E face of the intermediate membrane had few IMP and also linear arrays of slightly raised ridges running the length of the parasite. The P face of the intermediate membrane had many IMP aligned along the long axis of the sporozoite. On the P face of the inner membrane. IMP were arranged in very distinct rows conforming to the long axis of the parasite; the E face of this membrane had a few randomly distributed IMP. A prominent change in the sporozoite incubated in immune serum was the appearance of a layer of aggregated particles around the parasite. The P face of the plasma membrane had several clear areas devoid of IMP and IMP aggregates. No changes were seen in the other fractured faces of the pellicle. These observations suggest that immune serum acts only on the P face of the plasma membrane. 相似文献
53.
J M Behnke 《International journal for parasitology》1975,5(5):511-515
The distribution of larval Aspiculuris tetraptera was studied in 4-week-old male and female CFLP mice. Whereas on days 10–12 the larvae were entirely confined to the anterior third of the colon, by day 14 larvae could be found throughout the colon. After day 17 the larvae were again restricted to the anterior colon. This change in distribution was co-incident with a loss of a large proportion of the worm burden, which occurred more consistently in female than in male mice.The degree of acquired immunity stimulated by various immunizing regimens was assessed by the survival of a challenge infection in experimental and control mice. It was found that a high level of immunity was achieved by exposure to a 19-day primary infection, a 36-day low-level infection and also by three 6-day infections, in each of which the larvae were removed by piperazine treatment immediately after the crypt phase. 相似文献
54.
Baron R. W. and Tanner C. E. 1976. The effect of immunosuppression on secondary Echinococcus multilocularis infections in mice. International Journal for Parasitology6: 37–42. The growth of cysts of Echinococcus multilocularis in T-cell depleted A/J mice was studied. Adult thymectomy enhances the metastasis of hydatid cysts but does not significantly affect the total cyst weight. Combined thymectomy and antithymocyte serum (ATS) treatment also increases the metastatic dissemination of the parasite and also significantly increases cyst loads. It is suggested that cell-mediated immunity controls the early phase of Echinococcus infection. 相似文献
55.
《Cell》2022,185(18):3375-3389.e21
56.
BackgroundThis study is part of a national plan of epidemiological surveillance of malignant mesothelioma (MM) mortality in Italy. The paper shows the results of malignant peritoneal mesothelioma (MPeM) mortality study in Italian Regions and municipalities.MethodsNational Bureau of Statistics data for MPeM municipal mortality (ICD-10, Code C45.1) were analyzed in the time-window 2003–2014: mortality standardized rates (reference Italian population, census 2011), temporal trends of the annual national rates, Standardized Mortality Ratios and a municipal clustering analysis were performed.Results747 deaths for MPeM were recorded (0.10/100,000): 464 in men (0.14/100,000) and in 283 women (0.07/100,000). No significant MPeM mortality temporal trend was found.Seventeen municipalities showed excesses of mortality for MPeM in at least one gender and/or overall population.Four clusters in male population, and one in women were identified.ConclusionsThe study identifies some areas where remediation activities and/or health care actions may be warranted. 相似文献
57.
Arash Salmaninejad Saeed Farajzadeh Valilou Arezoo Gowhari Shabgah Saeed Aslani Malihe Alimardani Alireza Pasdar Amirhossein Sahebkar 《Journal of cellular physiology》2019,234(10):16824-16837
Over the course of past few years, cancer immunotherapy has been accompanied with promising results. However, preliminary investigations with respect to immunotherapy concentrated mostly on targeting the immune checkpoints, nowadays, emerge as the most efficient strategy to raise beneficial antitumor immune responses. Programmed cell death protein 1 (PD-1) plays an important role in subsiding immune responses and promoting self-tolerance through suppressing the activity of T cells and promoting differentiation of regulatory T cells. PD-1 is considered as an immune checkpoint and protects against autoimmune responses through both induction of apoptosis in antigen-specific T cells and inhibiting apoptosis in regulatory T cells. Several clinical trials exerting PD-1 monoclonal antibodies as well as other immune-checkpoint blockades have had prosperous outcomes and opened new horizons in tumor immunotherapy. Nonetheless, a bulk of patients have failed to respond to these newly emerging immune-based approach and the survival rate was not satisfying. Additional strategies, especially combination therapies, has been initiated and been further promising. Attempts to identify novel and well-suited predictive biomarkers are also sensed. In this review, the promotion of cancer immunotherapy targeting PD-1 immunoinhibitory pathway is discussed. 相似文献
58.
59.