全文获取类型
收费全文 | 49068篇 |
免费 | 17800篇 |
国内免费 | 370篇 |
出版年
2024年 | 19篇 |
2023年 | 116篇 |
2022年 | 145篇 |
2021年 | 625篇 |
2020年 | 3002篇 |
2019年 | 4543篇 |
2018年 | 4785篇 |
2017年 | 4748篇 |
2016年 | 4500篇 |
2015年 | 4380篇 |
2014年 | 4329篇 |
2013年 | 4740篇 |
2012年 | 4066篇 |
2011年 | 4216篇 |
2010年 | 3671篇 |
2009年 | 2554篇 |
2008年 | 2721篇 |
2007年 | 2194篇 |
2006年 | 2143篇 |
2005年 | 1824篇 |
2004年 | 1470篇 |
2003年 | 1521篇 |
2002年 | 1324篇 |
2001年 | 1040篇 |
2000年 | 547篇 |
1999年 | 394篇 |
1998年 | 145篇 |
1997年 | 122篇 |
1996年 | 127篇 |
1995年 | 99篇 |
1994年 | 98篇 |
1993年 | 113篇 |
1992年 | 108篇 |
1991年 | 87篇 |
1990年 | 91篇 |
1989年 | 82篇 |
1988年 | 73篇 |
1987年 | 48篇 |
1986年 | 57篇 |
1985年 | 67篇 |
1984年 | 52篇 |
1983年 | 27篇 |
1982年 | 46篇 |
1981年 | 31篇 |
1980年 | 17篇 |
1979年 | 28篇 |
1978年 | 23篇 |
1976年 | 15篇 |
1974年 | 13篇 |
1973年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
981.
Zhuo Chen Guangyong Chen Hang Zhao 《Journal of cellular and molecular medicine》2020,24(16):9055-9066
Glioma is one of the most lethal tumours and common malignant in the central nervous system (CNS), which exhibits diffuse invasion and aggressive growth. Several studies have reported the association of FDPS to tumour development and progression. However, the role of FDPS in progression of glioma and macrophage recruitment is not well‐elucidated. In the current study, a remarkable enhancement in FDPS level was observed in glioma tissues and associated with poor prognosis, contributed to tumour growth. FDPS was correlated with macrophage infiltration in glioma and pharmacological deletion of macrophages largely abrogated the oncogenic functions of FDPS in glioma. Mechanistically, FDPS activated Wnt/β‐catenin signalling pathway and ultimately facilitates macrophage infiltration by inducing CCL20 expression. In conclusion, overexpressed FDPS exhibits an immunomodulatory role in glioma. Therefore, targeting FDPS may be an effective therapeutic strategy for glioma. 相似文献
982.
983.
Yunhong Tian Yunming Tian Yinuo Tu Guoqian Zhang Xing Zeng Jie Lin Meiling Ai Zixu Mao Ronghui Zheng Yawei Yuan 《Journal of cellular and molecular medicine》2020,24(17):9533-9544
Cancer stem cells (CSCs) are a source of tumour recurrence in patients with nasopharyngeal carcinoma (NPC); however, the function of microRNA‐124 (miR‐124) in NPC CSCs has not been clearly defined. In this study, we investigated the role of miR‐124 in NPC CSCs. qRT‐PCR was performed to measure miR‐124 expression in NPC tissues and cell lines and the effects of miR‐124 on stem‐like properties and radiosensitivity of NPC cells measured. Luciferase reporter assays and rescue experiments were used to investigate the interaction of miR‐124 with the 3′UTR of junctional adhesion molecule A (JAMA). Finally, we examined the effects of miR‐124 in an animal model and clinical samples. Down‐regulation of miR‐124 was detected in cancer tissues and was inversely associated with tumour stage and lymph node metastasis. Overexpression of miR‐124 inhibited stemness properties and enhanced radiosensitivity of NPC cells in vitro and in vivo via targeting JAMA. Up‐regulation of miR‐124 was correlated with superior overall survival of patients with NPC. Our study demonstrates that miR‐124 can inhibit stem‐like properties and enhance radiosensitivity by directly targeting JAMA in NPC. These findings provide novel insights into the molecular mechanisms underlying therapy failure in NPC. 相似文献
984.
985.
986.
987.
988.
Ken Lin Lin‐Jing Song Jing Ma Tie‐Song Zhang Ding‐Yun You Yong‐Wen He 《Journal of cellular and molecular medicine》2020,24(9):5213-5223
Oral squamous cell carcinoma (OSCC) is the most common malignant tumour in the oral and maxillofacial region. Numerous cancers share ten common traits (“hallmarks”) that govern the transformation of normal cells into cancer cells. Long non‐coding RNAs (lncRNAs) are important factors that contribute to tumorigenesis. However, very little is known about the cooperative relationships between lncRNAs and cancer hallmark‐associated genes in OSCC. Through integrative analysis of cancer hallmarks, somatic mutations, copy number variants (CNVs) and expression, some OSCC‐specific cancer hallmark‐associated genes and lncRNAs are identified. A computational framework to identify gene and lncRNA cooperative regulation pairs (GLCRPs) associated with different cancer hallmarks is developed based on the co‐expression and co‐occurrence of mutations. The distinct and common features of ten cancer hallmarks based on GLCRPs are characterized in OSCC. Cancer hallmark insensitivity to antigrowth signals and self‐sufficiency in growth signals are shared by most GLCRPs in OSCC. Some key GLCRPs participate in many cancer hallmarks in OSCC. Cancer hallmark‐associated GLCRP networks have complex patterns and specific functions in OSCC. Specially, some key GLCRPs are associated with the prognosis of OSCC patients. In summary, we generate a comprehensive landscape of cancer hallmark‐associated GLCRPs that can act as a starting point for future functional explorations, the identification of biomarkers and lncRNA‐based targeted therapy in OSCC. 相似文献
989.
Yuan Xiong Chenchen Yan Lang Chen Yori Endo Yun Sun Wu Zhou Yiqiang Hu Liangcong Hu Dong Chen Hang Xue Bobin Mi Guohui Liu 《Journal of cellular and molecular medicine》2020,24(1):1076-1086
Interleukin‐10 (IL‐10) displays well‐documented anti‐inflammatory effects, but its effects on osteoblast differentiation have not been investigated. In this study, we found IL‐10 negatively regulates microRNA‐7025‐5p (miR‐7025‐5p), the down‐regulation of which enhances osteoblast differentiation. Furthermore, through luciferase reporter assays, we found evidence that insulin‐like growth factor 1 receptor (IGF1R) is a miR‐7025‐5p target gene that positively regulates osteoblast differentiation. In vivo studies indicated that the pre‐injection of IL‐10 leads to increased bone formation, while agomiR‐7025‐5p injection delays fracture healing. Taken together, these results indicate that IL‐10 induces osteoblast differentiation via regulation of the miR‐7025‐5p/IGF1R axis. IL‐10 therefore represents a promising therapeutic strategy to promote fracture healing. 相似文献
990.