全文获取类型
收费全文 | 1708篇 |
免费 | 186篇 |
国内免费 | 106篇 |
出版年
2024年 | 4篇 |
2023年 | 42篇 |
2022年 | 39篇 |
2021年 | 48篇 |
2020年 | 69篇 |
2019年 | 77篇 |
2018年 | 69篇 |
2017年 | 76篇 |
2016年 | 60篇 |
2015年 | 83篇 |
2014年 | 82篇 |
2013年 | 102篇 |
2012年 | 66篇 |
2011年 | 69篇 |
2010年 | 56篇 |
2009年 | 77篇 |
2008年 | 97篇 |
2007年 | 74篇 |
2006年 | 83篇 |
2005年 | 75篇 |
2004年 | 59篇 |
2003年 | 54篇 |
2002年 | 53篇 |
2001年 | 56篇 |
2000年 | 54篇 |
1999年 | 51篇 |
1998年 | 46篇 |
1997年 | 40篇 |
1996年 | 28篇 |
1995年 | 15篇 |
1994年 | 16篇 |
1993年 | 28篇 |
1992年 | 12篇 |
1991年 | 14篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 4篇 |
1987年 | 7篇 |
1986年 | 9篇 |
1985年 | 8篇 |
1984年 | 13篇 |
1983年 | 11篇 |
1982年 | 13篇 |
1981年 | 10篇 |
1980年 | 7篇 |
1979年 | 10篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1958年 | 3篇 |
排序方式: 共有2000条查询结果,搜索用时 15 毫秒
101.
The postulates of developmental instability–sexual selection hypothesis is intensely debated among evolutionary biologists, wherein despite a large amount of empirical data, evidence for or against it has been largely inconclusive. A key assumption of this hypothesis is that animals assess symmetry in potential mates as an indicator of genetic quality (developmental stability), and consequently use this information to discriminate against those with higher asymmetries while choosing mates. However, the perceptional basis that must underlie such discriminatory behavior (is symmetry a signal or is symmetry signaled) is not clearly defined. It is also argued that since asymmetry levels in natural populations are very low, the low signal‐to‐noise ratio would make accurate assessment of symmetry both difficult and costly. Rather than attempting to validate this hypothesis or even as to whether animals assess mate symmetry, this review simply aims to examine the plausibility that animals perceive symmetry (directly or indirectly) and consequently discriminate against asymmetric mates in response to perceived irregularities during courtship. For this, we review mate choice and courtship literature to identify potential sensory cues that might advertise asymmetry or lead to discrimination of asymmetric individuals. Although signaling associated with mate choice is commonly multimodal, previous studies on asymmetry have mainly focused on visual perception. In the light of a recent study (Vijendravarma et al., 2022, Proceedings of the National Academy of Sciences of the United States of America, 119, e2116136119), this review attempts to balance this bias by emphasizing on non‐visual perception of asymmetry. In conclusion, we discuss the methodological challenges associated with testing the role of multimodal cues in detecting mate asymmetry, and highlight the importance of considering ecological, behavioral, and evolutionary aspects of animals while interpreting empirical data that test such hypothesis. 相似文献
102.
Developmental stability, canalization, and phenotypic plasticity are the most common sources of phenotypic variation, yet comparative studies investigating the relationships between these sources, specifically in plants, are lacking. To investigate the relationships among developmental stability or instability, developmental variability, canalization, and plasticity in plants, we conducted a field experiment with Abutilon theophrasti, by subjecting plants to three densities under infertile vs. fertile soil conditions. We measured the leaf width (leaf size) and calculated fluctuating asymmetry (FA), coefficient of variation within and among individuals (CVintra and CVinter), and plasticity (PIrel) in leaf size at days 30, 50, and 70 of plant growth, to analyze the correlations among these variables in response to density and soil conditions, at each of or across all growth stages. Results showed increased density led to lower leaf FA, CVintra, and PIrel and higher CVinter in fertile soil. A positive correlation between FA and PIrel occurred in infertile soil, while correlations between CVinter and PIrel and between CVinter and CVintra were negative at high density and/or in fertile soil, with nonsignificant correlations among them in other cases. Results suggested the complexity of responses of developmental instability, variability, and canalization in leaf size, as well as their relationships, which depend on the strength of stresses. Intense aboveground competition that accelerates the decrease in leaf size (leading to lower plasticity) will be more likely to reduce developmental instability, variability, and canalization in leaf size. Increased developmental instability and intra‐ and interindividual variability should be advantageous and facilitate adaptive plasticity in less stressful conditions; thus, they are more likely to positively correlate with plasticity, whereas developmental stability and canalization with lower developmental variability should be beneficial for stabilizing plant performance in more stressful conditions, where they tend to have more negative correlations with plasticity. 相似文献
103.
C. elegans embryos, larvae, and adults exhibit several left-right asymmetries with an invariant dextral handedness, which first becomes evident in the embryo at the 6-cell stage. Reversed (sinistral) handedness was not observed among > 10,000 N2 adults reared at 16°C or 20°C under standard conditions. However, among the progeny of adults reproducing at 10°C, the frequency of animals with sinistral handedness was increased to ∼0.5%. Cold pulse experiments indicated that the critical period for this increase was in early oogenesis, several hours before the first appearance of left-right asymmetry in the embryo. Hermaphrodites reared at 10°C and mated with males reared at 20°C produced sinistral outcross as well as sinistral self-progeny, indicating that the low temperature effect on oocytes was sufficient to cause reversals. Increased frequency of reversal was also observed among animals developed from embryos lacking the egg shell. Possible mechanisms for the control of embryonic handedness are discussed in the context of these results, including the hypothesis that handedness could be dictated by the chirality of a gametic component. © 1996 Wiley-Liss, Inc. 相似文献
104.
105.
Tarsal asymmetry, nutritional condition, and survival in water boatmen (Callicorixa Vulnerata) 总被引:1,自引:0,他引:1
Fluctuating asymmetry (FA) has been used as a measure of developmental stability and may indicate individual phenotypic or genotypic quality. Using water boatmen (Callicorixa vulnerata) from a natural population, we examined the relationship between tarsal FA (tarsal spine number, tarsal length) and indices of body condition in two habitats. We used body weight and residual body weight (controlling for body length) as indices of condition because experimental food deprivation in water boatmen led to a reduction in each. We detected a negative relationship between FA and both indices of condition in two ecologically distinct pond habitats. We predicted this association was due to a negative relationship between FA and competitive feeding ability. Consequently, we examined associations between survival time and tarsal FA in C. vulnerata under resource-limited laboratory conditions. Univariate analyses revealed a negative correlation between survival and tarsal FA in each trait. Inclusion of survival time, body length, gender, tarsal spine number, tarsal length, and measures of FA into multivariate analyses revealed a negative correlation between survival and FA. Individuals with the greatest survival had higher nutritional condition than individuals that succumbed early in the experiment. Asymmetric individuals may suffer a foraging handicap as a result of the use of tarsi in feeding or they may be of poor genetic quality. Our results suggest elevated FA may limit resource acquisition and are consistent with the use of FA as a measure of fitness. 相似文献
106.
Irene M.A. Nooren Albert V.E. George Robert Kaptein Robert T. Sauer Rolf Boelens 《Journal of biomolecular NMR》1999,15(1):39-53
The structure and dynamics of the chymotryptic tetramerization domain of the Mnt repressor of Salmonella bacteriophage P22 have been studied by NMR spectroscopy. Two sets of resonances (A and B) were found, representing the asymmetry within the homotetramer. Triple-resonance techniques were used to obtain unambiguous assignments of the A and B resonances. Intra-monomeric NOEs, which were distinguished from the inter-monomeric NOEs by exploiting 13C/15N-filtered NOE experiments, demonstrated a continuous -helix of approximately seven turns for both the A and B monomers. The asymmetry facilitated the interpretation of inter-subunit NOEs, whereas the antiparallel alignment of the subunits allowed further discrimination of inter-monomeric NOEs. The three-dimensional structure revealed an unusual asymmetric packing of a dimer of two antiparallel right-handed intertwined coiled -helices. The A and B forms exchange on a timescale of seconds by a mechanism that probably involves a relative sliding of the two coiled coils. The amide proton solvent exchange rates demonstrate a stable tetrameric structure. The essential role of Tyr 78 in oligomerization of Mnt, found by previous mutagenesis studies, can be explained by the many hydrophobic and hydrogen bonding interactions that this residue participates in with adjacent monomers. 相似文献
107.
Abstract Three major types of bilateral asymmetry (fluctuating asymmetry, directional asymmetry, and antisymmetry) have long been recognized in the literature. Little, however, is known about transitions between asymmetry types, especially in natural populations. It is often assumed that directional asymmetry and antisymmetry have a larger genetic basis than fluctuating asymmetry. This leads many scientists to exclude traits or populations showing either directional asymmetry or antisymmetry from developmental instability studies, focusing attention on fluctuating asymmetry alone. This procedure may bias the findings and thus our understanding of patterns of bilateral asymmetry and the factors influencing it. To examine changes in bilateral asymmetry across the distribution range of a species, I studied the length of the third toe in 11 chukar partridge (Alectoris chukar) populations across a steep environmental gradient of 320 km within the species' range in Israel. This trait was selected due to its adaptive value in the chukar, a species that spends much of its activity walking, and due to its high measurement repeatability. Moving from the core toward the very extreme periphery of the range, the following four trends are detected: (1) the expression of the directional asymmetry component significantly increases; (2) the frequency of symmetrical individuals in the population significantly decreases, with a sharp decline at the steepest part of the climatic and environmental gradient studied, within the Mediterranean‐desert ecotone; (3) mean asymmetry levels, as estimated using the unsigned difference between the right and left toe, significantly increases; and (4) the range of asymmetry increases such that the most asymmetrical individuals originate from the very edge of the range. These findings provide primary evidence that substantial shifts in asymmetry may occur across short geographical distances within a species' distribution range. They show a continuum between asymmetry types and support the notion that all three types of asymmetry can reflect developmental instability. Further studies of developmental instability should be designed so that they enable detection of transitions between asymmetry types across natural populations. Such a procedure may partly resolve some of the contradictions seen in the literature regarding the relationship between bilateral asymmetry and environmental stress. 相似文献
108.
Prauchner CA Agostini AN Morimoto A Augusti PR Unfer TC Zeni G Mello CF Emanuelli T 《Neurochemical research》2004,29(10):1793-1800
We investigated whether intrastriatal (i.s.) administration of 5-aminolevulinic acid (ALA) induces oxidative damage and whether behavioral alterations induced by i.s. administration of ALA could be affected by antioxidants. Unilateral injection of ALA (6 micromol/striatum) increased (approximately 30%) thiobarbituric acid-reactive substances (TBARS), but did not affect striatal content of total thiol groups. ALA-induced body asymmetry was not prevented by pretreatment with ascorbic acid (100 mg/kg, s.c.), dimethyl sulfoxide (DMSO, 0.5 microl/striatum, i.s.) or ebselen (10 nmol/striatum, i.s.). ALA-induced convulsions were not prevented by ascorbic acid, but were partially prevented by DMSO and completely prevented by ebselen. Ebselen completely prevented the increase of striatal TBARS induced by ALA. Results obtained suggest the involvement of reactive species in ALA-induced convulsions and may be of value in understanding the physiopathology of neurological dysfunctions associated to ALA overload. 相似文献
109.
Plants are able to compensate for loss of tissue due to herbivores at a variety of spatial and temporal scales, masking detrimental effects of herbivory on plant fitness at these scales. The stressing effect of herbivory could also produce instability in the development of plant modules, and measures of such instability may reflect the fitness consequences of herbivory if instability is related to components of plant fitness. We analyse the relationships between herbivory, developmental instability and production of female flowers and fruits of holm oak Quercus ilex trees by means of herbivore removal experiments. Removal of leaf herbivores reduced herbivory rates at the tree level, but had no effect on mean production of female flowers or mature fruits, whereas herbivory tended to enhance flower production and had no effect on fruit abortion at the shoot level. Differences in herbivory levels between shoots of the same branch did not affect the size and fluctuating asymmetry of intact leaves. These results indicate compensation for herbivory at the tree level and over-compensation at the shoot level in terms of allocation of resources to female flower production. Removal of insect herbivores produced an increase in the mean developmental instability of leaves at the tree level in the year following the insecticide treatment, and there was a direct relationship between herbivory rates in the current year and leaf fluctuating asymmetry the following year irrespective of herbivore removal treatment. Finally, the production of pistillate flowers and fruits by trees was inversely related to the mean fluctuating asymmetry of leaves growing the same year. Leaf fluctuating asymmetry was thus an estimator of the stressing effects of herbivory on adult trees, an effect that was delayed to the following year. As leaf fluctuating asymmetry was also related to tree fecundity, asymmetry levels provided a sensitive measure of plant performance under conditions of compensatory responses to herbivory. 相似文献
110.
Cooke J 《Biological reviews of the Cambridge Philosophical Society》2004,79(2):377-407
The systematically 'handed', or directionally asymmetrical way in which the major viscera are packed within the vertebrate body is known as situs. Other less obvious vertebrate lateralisations concern cognitive neural function, and include the human phenomena of hand-use preference and language-associated cognitive partitioning. An overview, rather than an exhaustive scholarly review, is given of recent advances in molecular understanding of the mechanism that ensures normal development of 'correct' situs. While the asymmetry itself and its left/right direction are clearly vertebrate-conserved characters, data available from various embryo types are compared in order to assess the likelihood that the developmental mechanism is evolutionarily conserved in its entirety. A conserved post-gastrular 'phylotypic' stage, with left- and right-specific cascades of key, orthologous gene expressions, clearly exists. It now seems probable that earlier steps, in which symmetry-breaking information is reliably transduced to trigger these cascades on the correct sides, are also conserved at depth although it remains unclear exactly how these steps operate. Earlier data indicated that the initiation of symmetry-breaking had been transformed, among the different vertebrate classes, as drastically as has the anatomy of pre-gastrular development itself, but it now seems more likely that this apparent diversity is deceptive. Ideas concerning the functional advantages to the vertebrate lifestyle of a systematically asymmetrical visceral packing arrangement, while untestable, are accepted because they form a plausible adaptationist 'just-so' story. Nevertheless, two contrasting beliefs are possible about the evolutionary origins of situs. Major recent advances in analysis of its developmental mechanism are largely due not to zoologists, comparative anatomists or evolutionary systematists, but to molecular geneticists, and these workers have generally assumed that the asymmetry is an evolutionary novelty imposed on a true bilateral symmetry, at or close to the origin of the vertebrate clade. A major purpose of this review is to advocate an alternative view, on the grounds of comparative anatomy and molecular systematics together with the comparative study of expressions of orthologous genes in different forms. This view is that situs represents a co-optation of a pre-existing, evolutionarily ancient non-bilaterality of the adult form in a vertebrate ancestor. Viewed this way, vertebrate or chordate origins are best understood as the novel imposition of an adaptively bilateral locomotory-skeletal-neural system, around a retained non-symmetrical 'visceral' animal. One component of neuro-anatomical asymmetry, the habenular/parapineal one that originates in the diencephalon, has recently been found (in teleosts) to be initiated from the same 'phylotypic' gene cascade that controls situs development. But the function of this particular diencephalic asymmetry is currently unclear. Other left-right partitionings of brain function, including the much more recently evolved, cerebral cortically located one associated with human language and hand-use, may be controlled entirely separately from situs even though their directionality has a particular relation to it in a majority of individuals. Finally, possible relationships are discussed between the vertebrate directional asymmetries and those that occur sporadically among protostome bilaterian forms. These may have very different evolutionary and molecular bases, such that there may have been constraints, in protostome evolution, upon any exploitation of left and right for complex organismic, and particularly cognitive neural function. 相似文献