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161.
Personality effects on spatial learning: Comparisons between visual conditions in a weakly electric fish 下载免费PDF全文
Kyriacos Kareklas Robert W. Elwood Richard A. Holland 《Ethology : formerly Zeitschrift fur Tierpsychologie》2017,123(8):551-559
Recent research has explored links between cognition and personality, with prominent hypotheses proposing that personality drives consistent individual differences in cognitive function. These hypotheses particularly expect bolder individuals to be faster, but less accurate, as a trade‐off in cognitive function. However, cognitive processes are typically interconnected and defined in more complex terms than simply speed and accuracy. Here, we present evidence that personality‐based differences in learning rates are a result of differences in decision‐making during training in a two‐alternative forced‐choice spatial memory task. This was examined in the mormyrid fish Gnathonemus petersii in the presence of light, where both vision and the electric sense are available, and in the dark, where visibility is limited and fish rely mostly on electrosensing. The species is adapted for the dark to avoid visual predators; thus, the presence of light can induce high‐risk and the dark low‐risk. We show that light conditions had little effect on learning, with bolder fish learning faster both in the light and in the dark conditions. Yet the relationship between learning rates and error rates indicates that the effect on learning is indirectly influenced by accuracy during training. Speed‐accuracy trade‐offs were not found in decision‐making, with bolder individuals deciding faster and more accurately both in the light and in the dark. Only learning strategy was affected by light conditions, with significantly more fish preferring response to place learning in the dark than in the light, where distal cues were not visible. We conclude that other than effects from the integration of visual information, bolder individuals show a consistently greater tendency to explore and find food rewards during training. This affects their decision‐making and in turn their learning performance. We highlight the complexity by which personality‐based effects are exhibited in spatial associative learning. 相似文献
162.
Chengjie G. Huang 《Channels (Austin, Tex.)》2017,11(4):281-304
Ion channels play essential roles toward determining how neurons respond to sensory input to mediate perception and behavior. Small conductance calcium-activated potassium (SK) channels are found ubiquitously throughout the brain and have been extensively characterized both molecularly and physiologically in terms of structure and function. It is clear that SK channels are key determinants of neural excitability as they mediate important neuronal response properties such as spike frequency adaptation. However, the functional roles of the different known SK channel subtypes are not well understood. Here we review recent evidence from the electrosensory system of weakly electric fish suggesting that the function of different SK channel subtypes is to optimize the processing of independent but behaviorally relevant stimulus attributes. Indeed, natural sensory stimuli frequently consist of a fast time-varying waveform (i.e., the carrier) whose amplitude (i.e., the envelope) varies slowly and independently. We first review evidence showing how somatic SK2 channels mediate tuning and responses to carrier waveforms. We then review evidence showing how dendritic SK1 channels instead determine tuning and optimize responses to envelope waveforms based on their statistics as found in the organism's natural environment in an independent fashion. The high degree of functional homology between SK channels in electric fish and their mammalian orthologs, as well as the many important parallels between the electrosensory system and the mammalian visual, auditory, and vestibular systems, suggest that these functional roles are conserved across systems and species. 相似文献
163.
目的:观察高脂饲养至青春期的大鼠对电击回避反应和海马CA3区实时局部场电位变化。方法:断乳1周幼鼠改用基础饲料和高脂饲料分别喂养4周至青春期,分为基础饲料组(BF组)和高脂饲料组(HFD组),Y型迷宫电击回避训练方法,记录2组大鼠电击回避达学会标准的相关参数,同时无线遥测大鼠达标时海马CA3区实时局部场电位。结果:与BF组大鼠比较,HFD组大鼠体重明显增加,Y型迷宫电击回避训练1~2 d大鼠达标百分率、电击回避达标各项指标均略优于BF组;双侧海马CA3区局部场电位节律出现去同步化快波改变,右侧海马CA3区出现了θ波和γ 1波百分比的同步性增加,但无θ~γ 1波相位-振幅耦合出现。结论:幼年期短期高脂饮食至青春期的大鼠,尽管体重较基础饲料大鼠增加,但未见Y型迷宫电击回避反应能力和海马依赖性空间认知功能的减退。 相似文献
164.
Aims: To study the influence of growth temperature on the resistance of Escherichia coli to three agents of different nature: heat, pulsed electric field (PEF) and hydrogen peroxide.
Methods and Results: Escherichia coli cells were grown to stationary phase at 10°C, 20°C, 30°C, 37°C and 42°C. Survival curves to a heat treatment at 57·5°C, to a PEF treatment at 22 kV cm−1 and to 40 mmol l−1 hydrogen peroxide were obtained and fitted to a model based on the Weibull distribution to describe and compare the inactivation. Time to inactivate the first log cycle of the population at 57·5°C of cells grown at 42°C was sixfold higher than that corresponding to cells grown at 10°C. On the contrary, cells grown at 10°C and 20°C were more resistant to PEF and hydrogen peroxide treatments.
Conclusions: The influence of growth temperature on bacterial resistance depends on the stress applied. Cells grown at higher temperatures were more heat resistant, but more sensitive to PEF and hydrogen peroxide.
Significance and Impact of the Study: Results obtained in this investigation help in understanding the physiology of bacterial resistance and the inactivation mechanisms of different technologies. 相似文献
Methods and Results: Escherichia coli cells were grown to stationary phase at 10°C, 20°C, 30°C, 37°C and 42°C. Survival curves to a heat treatment at 57·5°C, to a PEF treatment at 22 kV cm
Conclusions: The influence of growth temperature on bacterial resistance depends on the stress applied. Cells grown at higher temperatures were more heat resistant, but more sensitive to PEF and hydrogen peroxide.
Significance and Impact of the Study: Results obtained in this investigation help in understanding the physiology of bacterial resistance and the inactivation mechanisms of different technologies. 相似文献
165.
166.
基于PC声卡的生物医学电信号采集方法 总被引:1,自引:0,他引:1
把生物医学电信号以线性调幅的方法调制在音频载波信号之上,用PC声卡采集该已调波信号,用软件实现调幅波的解调,经数字低通滤波器的滤波,恢复出生物医学电信号,达到采集和显示生物医学电信号的的目的。实践证明,该方法具有成本低、多通道工作实时性好的特点,具有实用价值。 相似文献
167.
M. V. Satarić D. I. Ilić N. Ralević Jack Adam Tuszynski 《European biophysics journal : EBJ》2009,38(5):637-647
Microtubules (MTs) are important cytoskeletal polymers engaged in a number of specific cellular activities including the traffic
of organelles using motor proteins, cellular architecture and motility, cell division and a possible participation in information
processing within neuronal functioning. How MTs operate and process electrical information is still largely unknown. In this
paper we investigate the conditions enabling MTs to act as electrical transmission lines for ion flows along their lengths.
We introduce a model in which each tubulin dimer is viewed as an electric element with a capacitive, inductive and resistive
characteristics arising due to polyelectrolyte nature of MTs. Based on Kirchhoff’s laws taken in the continuum limit, a nonlinear
partial differential equation is derived and analyzed. We demonstrate that it can be used to describe the electrostatic potential
coupled to the propagating localized ionic waves.
An erratum to this article can be found at 相似文献
168.
Re-examination of the electro-radicogram (ERG) obtained during past 10 years research (Masaki and Okamoto in Trees (Berl)
21:433–442, 2007) enabled us to discriminate the excess activity of the electrogenic ion pump in the root surface cell membrane over that
of the xylem pump during most of the foliate phase. The trans-root electric potential (TRP) is defined as the difference between
V
ps (electric potential difference between symplast and bulk water phase surrounding the root) and V
px (electric potential difference between symplast and xylem apoplast). The diurnal oscillation of TRP followed that of the
air temperature and/or light intensity with a delay of several hours during defoliate phase. This means the superiority of
the electrogenic activity of the xylem pump over that of the root surface pump. However, after leaf expansion, TRP began to
oscillate inversely with the temperature change with a short delay, indicating the superiority of the electrogenic activity
of the surface ion pump over that of the xylem pump. An experimental lumbering of the surroundings of the kaki tree in foliate
phase prominently increased the ERG amplitude, keeping the inverted phase relation, with the increase in transpiration caused
by the increased illumination. An incidental sudden fall of the temperature and illumination caused an inverse reaction. 相似文献
169.
刘勇 《上海生物医学工程》2009,(3):175-177
回顾了心脏电生理方法学和器械进步的早期基石,并阐述了以导管和起搏技术为特点的心内电生理学若干标志性新方法、新领域、新进展。进而展望了心脏电生理方法学的若干发展方向。 相似文献
170.
Takahashi A Kondoh M Uchida H Kakamu Y Hamakubo T Yagi K 《Biochemical and biophysical research communications》2011,(3):317-470
Passage across epithelial cell sheets is the first step in drug absorption. Tight junctions (TJs) are located between adjacent epithelial cells and seal the intercellular space preventing leakage of solutes. Claudin, a tetra-transmembrane protein family, is a pivotal functional and structural component of the TJ barrier. Modulation of the claudin-based TJ seal is a strategy for mucosal drug absorption. We previously found that a claudin-4 binder, a C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE194), was a modulator of the TJ seal and a potent mucosal absorption enhancer. In the present study, we attempted to improve claudin-4 binders by modification of C-CPE194. Substitution of Asn at position 309 and Ser at position 313 with Ala increased the affinity to claudin-4 by 9.9-fold as compared to C-CPE194. Deletion of 10 amino acids in the N-terminal domain of the double-alanine-substituted mutant increased affinity to claudin-4 by 23.9-fold as compared to C-CPE194. These C-CPE194 mutants reversibly modulated the TJ seal in human intestinal epithelial cell sheets. The N-terminal-truncated mutant was the most potent modulator of the TJ seal. These findings indicate that the C-CPE mutant may be a promising lead for the development of a clinical TJ modulator. 相似文献