全文获取类型
收费全文 | 502篇 |
免费 | 78篇 |
国内免费 | 39篇 |
出版年
2024年 | 1篇 |
2023年 | 31篇 |
2022年 | 36篇 |
2021年 | 52篇 |
2020年 | 45篇 |
2019年 | 36篇 |
2018年 | 40篇 |
2017年 | 35篇 |
2016年 | 30篇 |
2015年 | 38篇 |
2014年 | 45篇 |
2013年 | 43篇 |
2012年 | 22篇 |
2011年 | 14篇 |
2010年 | 18篇 |
2009年 | 21篇 |
2008年 | 6篇 |
2007年 | 20篇 |
2006年 | 11篇 |
2005年 | 15篇 |
2004年 | 10篇 |
2003年 | 4篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1985年 | 3篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有619条查询结果,搜索用时 31 毫秒
611.
Meng-Tse Gabe Lee Ashwini Mishra David G. Lambright 《Traffic (Copenhagen, Denmark)》2009,10(10):1377-1389
In all eukaryotic organisms, Rab GTPases function as critical regulators of membrane traffic, organelle biogenesis and maturation, and related cellular processes. The numerous Rab proteins have distinctive yet overlapping subcellular distributions throughout the endomembrane system. Intensive investigation has clarified the underlying molecular and structural mechanisms for several ubiquitous Rab proteins that control membrane traffic between tubular-vesicular organelles in the exocytic, endocytic and recycling pathways. In this review, we focus on structural insights that inform our current understanding of the organization of the Rab family as well as the mechanisms for membrane targeting and activation, interaction with effectors, deactivation and specificity determination. 相似文献
612.
《Molecular cell》2023,83(11):1839-1855.e13
613.
614.
615.
616.
Jiao Du Qiying Wang Hongwei Shi Changyong Zhou Jun He Xuefeng Wang 《Molecular Plant Pathology》2023,24(4):302-316
Citrus huanglongbing (HLB), associated with the unculturable phloem-limited bacterium “Candidatus Liberibacter asiaticus” (CLas), is the most devastating disease in the citrus industry worldwide. However, the pathogenicity of CLas remains poorly understood. In this study, we show that AGH17488, a secreted protein encoded by the prophage region of the CLas genome, suppresses plant immunity via targeting the host ASCORBATE PEROXIDASE6 (APX6) protein in Nicotiana benthamiana and Citrus sinensis. The transient expression of AGH17488 reduced the chloroplast localization of APX6 and its enzyme activity, inhibited the accumulation of reactive oxygen species (H2O2 and O2−) and the lipid oxidation endproduct malondialdehyde in plants, and promoted the proliferation of Pseudomonas syringae pv. tomato DC3000 and Xanthomonas citri subsp. citri. This study reveals a novel mechanism underlying how CLas uses a prophage-encoded effector, AGH17488, to target a reactive oxygen species accumulation-related gene, APX6, in the host to facilitate its infection. 相似文献
617.
618.
619.
Denise Chung Shazia Amar Albert Glozman James M. Chen Fred K. Friedman Richard Robinson Regina Monaco Paul Brandt-Rauf Z. Yamaizumi Matthew R. Pincus 《Journal of Protein Chemistry》1997,16(6):631-635
In the preceding paper we found from molecular dynamics calculations that the structure of the ras-binding domain (RBD) of raf changes predominantly in three regions depending upon whether it binds to ras-p21 protein or to its inhibitor protein, rap-1A. These three regions of the RBD involve residues from the protein–protein interaction interface, e.g., between residues 60 and 72, residues 97–110, and 111–121. Since the rap-1A–RBD complex is inactive, these three regions are implicated in ras-p21-induced activation of raf. We have therefore co-microinjected peptides corresponding to these three regions, 62–76, 97–110, and 111–121, into oocytes with oncogenic p21 and microinjected them into oocytes incubated in in insulin, which activates normal p2l. All three peptides, but not a control peptide, strongly inhibit both oncogenic p21- and insulin-induced oocyte maturation. These findings corroborate our conclusions from the theoretical results that these three regions constitute raf effector domains. Since the 97–110 peptide is the strongest inhibitor of oncogenic p21, while the 111–121 peptide is the strongest inhibitor of insulin-induced oocyte maturation, the possibility exists that oncogenic and activated normal p21 proteins interact differently with the RBD of raf. 相似文献