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《Biomarkers》2013,18(7):595-600
AbstractContext: Stroke and/or white matter lesions (WMLs) are significant in Fabry disease. Polymorphisms of angiotensinogen (AGT), AGT Promoter and angiotensinogen II receptor type 1 (AGTR1) are correlated with WMLs.Objectives: We compared AGT. AGT Promoter and AGTR1 genotypes to stroke incidence, Fabry-specific [Mainz Severity Score Index (MSSI)] severity score, and neurologic sub-score (n-MSSI).Methods: Sixty-three Fabry patients and 49 matched controls plus historic controls were genotyped. Institutional Review Board approval was received.Results. C and/or CC alleles of AGT Promoter and AGTR1 were significantly correlated with stroke and n-MSSI.Discussion/conclusion: Findings are suggestive of role of AGT Promoter and AGTR1 genotypes in Fabry phenotypes. 相似文献
14.
T. R. Shankar Raman 《Journal of biosciences》1997,22(2):203-218
Chital or axis deer (Axis axis) form fluid groups that change in size temporally and in relation to habitat. Predictions of hypotheses relating animal density,
rainfall, habitat structure, and breeding seasonality, to changes in chital group size were assessed simultaneously using
multiple regression models of monthly data collected over a 2 yr period in Guindy National Park, in southern India. Over 2,700
detections of chital groups were made during four seasons in three habitats (forest, scrubland and grassland). In scrubland
and grassland, chital group size was positively related to animal density, which increased with rainfall. This suggests that
in these habitats, chital density increases in relation to food availability, and group sizes increase due to higher encounter
rate and fusion of groups. The density of chital in forest was inversely related to rainfall, but positively to the number
of fruiting tree species and availability of fallen litter, their forage in this habitat. There was little change in mean
group size in the forest, although chital density more than doubled during the dry season and summer. Dispersion of food items
or the closed nature of the forest may preclude formation of larger groups. At low densities, group sizes in all three habitats
were similar. Group sizes increased with chital density in scrubland and grassland, but more rapidly in the latter—leading
to a positive relationship between openness and mean group size at higher densities. It is not clear, however, that this relationship
is solely because of the influence of habitat structure. The rutting index (monthly percentage of adult males in hard antler)
was positively related to mean group size in forest and scrubland, probably reflecting the increase in group size due to solitary
males joining with females during the rut. The fission-fusion system of group formation in chital is thus interactively influenced
by several factors. Aspects that need further study, such as interannual variability, are highlighted. 相似文献
15.
Summary Video-densitometric DNA measurements of Feulgenstained tissues of 42 day old eggs of the corn snake,Elaphe g. guttata (Columbridae, Serpentes), revealed a basic DNA content of 2C=2.17 pg, with somatic polyploidy in the allantois, the chorioallontois, the yolk sac, and other extraembryonic membranes. The maximum value determined was 128C (in binucleate cells 2×128C) at the distal pole of the egg. This is the first report of somatic polyploidy in a snake, and one of the first in reptiles in general. 相似文献
16.
Faranak Khanahmadi Mehdi Rahimmalek Mohammad R. Sabzalian Behnaz Tohidi 《化学与生物多样性》2021,18(6):e2100097
The production of self-pollinated plants could be important for improving medicinal plants secondary metabolites. In this study, 11 Thymus populations from eight species were evaluated to determine the effect of self and open pollination on agro-morphological characteristics, total phenolic content (TPC), essential oil (EO) content, and EO components. Inbreeding led to some positive effects of above mentioned traits in most of the studied populations. Total phenolic content ranged from 7.07 to 52.69 mg tannic acid equivalents (TAE) g−1 dry weight (DW) in open pollinated derived populations, while it varied from 1.2 to 55.03 mg TAE g−1 DW in self-pollinated ones. Under open and self-pollination condition, the highest EO content was obtained in T. trautvetteri (3.37 %) and T. pubescens (1.96 %), respectively. Gas chromatography-mass spectrometry (GC/MS) identified 42 compounds including thymol, carvacrol, linalool, p-cymene, γ-terpinene, terpinen-4-ol, and α-terpineol as the main compounds. In most cases, selfed plants compared to open pollinated ones, revealed higher thymol content. T. daenensis-1 showed a significant increase in thymol content (from 25.22 % to 74.3 %) due to self-pollination. Moreover, self-pollination led to emergence of some new compounds. Carvacrol methyl ether was the constituents of Thymus EO that are being reported in self-pollinated populations. Finally, inbreeding in Thymus might be suggested as a useful tool to increase genetic homogeneity for the selection of superior plants for improving secondary metabolite. 相似文献
17.
One hundred and thirty Atlantic sharpnose shark Rhizoprionodon terraenovae livers were collected from April 1999 to October 2001 from inshore waters of the Mississippi Sound to investigate seasonal and inter‐annual variation in their energetic condition. A decline in the hepato‐somatic index ( I H ) was observed from 1999 to 2001. In addition, I H , liver specific energy content and total energy content were lowest during the summer and highest during the spring and autumn, while liver water content was highest during the summer and lowest during the spring and autumn. 相似文献
18.
19.
Caryl A. Chlan Katyna Borroto J. A. Kamalay Leon Dure III 《Plant molecular biology》1987,9(6):533-546
The globulin storage protein genes of cotton are found to exist as gene tandems that contain a gene from each of the 2 globulin subfamilies separated by a spacer region of about 2700 or 3400 base pairs. Three different tandems have been identified by restriction endonuclease mapping of genomic DNA. A cDNA that is different from the genes of the tandems in map sites and/or in nucleotide sequence indicates that a fourth tandem probably exists in the cotton genome. Since the species of cotton used here (Gossypium hirsutum) is an amphidiploid, it is likely that two of the tandems are contributed from each genome.Considerable divergence in nucleotide sequence (18%) and in derived amino acid sequence (28%) is found when the 2 genes of a sequenced tandem are compared. The sequence of the cDNA closely resembles one of the genes in the tandem showing only a 4% divergence in nucleotides and a 4.2% divergence in amino acids. Thus the 2 genes of each tandem represent a relatively ancient gene duplication that has given rise to the two globulin subfamilies of cotton. Only one subfamily has a glycosylation site and the glycosylation of its derived proteins gives rise to the 2 molecular weight sets of globulins seen on gel electrophoresis.Other basic features of these genes and their derived proteins are presented. 相似文献
20.
Sudha Rao Gopalakrishna Kamath Gururaj Maralihalli Anil S. Bhagwat 《Photosynthesis research》1987,12(2):155-164
The -aminolevulinic acid dehydratase activity was irreversibly inactivated by irradiation of the enzyme in presence of flavin mononucleotide. The loss of enzyme activity was dependent on time of irradiation, concentration of FMN and intensity of irradiance. It required oxygen and was markedly enhanced in heavy water. The presence of levulinic acid (a competitive inhibitor of -ALAD) during irradiation prevented the inactivation considerably indicating photooxidative damage at or near the active site. Superoxide dismutase, sodium benzoate and sodium formate offered no protection, but singlet oxygen quenchers like azide and tryptophan were effective. NADH, electron donor to excited flavins, also prevented the loss of enzyme activity. These results indicate that singlet oxygen produced by light absorption of FMN was responsible for the photooxidative inhibition of the enzyme.Abbreviations ALAD
-aminolevulinic acid dehydratase
- FMN
flavin mononucleotide
- O2
-
superoxide
- H2O2
hydrogen peroxide
- 102
singlet oxygen
- LA
levulinic acid
- PBG
porphobilinogen
- BSA
bovine serum albumin
- BME
2-mercaptoethanol
- SOD
superoxide dismutase
- pHMB
para-hydroxymercuribenzoate
- DTT
dithiothreitol
- FAD
flavin adenine dinucleotide
- NADH
nicotinamide adenine dinucleotide 相似文献