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Martingale-based residuals for survival models 总被引:27,自引:0,他引:27
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This review focuses on utilization of plant lectins as medical diagnostic reagents and tools. The lectin-related diagnostic
is aimed at detection of several diseases connected to alteration of the glycosylation profiles of cells and at identification
of microbial and viral agents in clinical microbiology. Certain lectins, proposed for or used as diagnostic tools could even
recognize those cellular determinants, which are not detected by available antibodies. Broad information is presented on the
lectinomics field, illustrating that lectin diagnostics might become practical alternative to antibody-based diagnostic products.
In addition, the rising trend of lectin utilization in biomedical diagnostics might initiate a development of innovative methods
based on better analytical technologies. Lectin microarray, a rapid and simple methodology, can be viewed as an example for
such initiative. This technology could provide simple and efficient screening tools for analysis of glycosylation patterns
in biological samples (cellular extracts, tissues and the whole cells), allowing thus personalized detection of changes associated
with carbohydrate-related diseases. 相似文献
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Robert A. Robinson Jeremy D. Wilson† Humphrey Q.P. Crick 《Journal of Applied Ecology》2001,38(5):1059-1069
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《Biotechnic & histochemistry》2013,88(3):235-239
AbstractIn this 12th issue of News from the Biological Stain Commission (BSC) under the heading of Regulatory affairs, the Biological Stain Commission’s International Affairs Committee presents information from the meetings of ISO/TC 212/WG 1 Quality and competence in the medical laboratory and ISO/TC 212/WG 3 In vitro diagnostic products both held on 2 – 3 June 2010, plus information on the second plenary meeting of ISO/TC 212 Clinical laboratory testing and in vitro diagnostic test systems held on 4 June 2010. All meetings took place in Seoul, Republic of Korea. Finally, information is provided concerning the 25th meeting of CEN/TC 140 In vitro diagnostic medical devices held on 23 June 2010 in Berlin, Germany. 相似文献
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Lei Zhang Yuan Zhang Sheng Xue Han Ding Yu Wang Hongzhao Qi Yin Wang Wenjie Zhu Peifeng Li 《Journal of cellular and molecular medicine》2020,24(1):1146-1150
Coronary artery disease (CAD) is one of the biggest threats to human life. Circulating microRNAs (miRNAs) have been reported to be linked to the pathogenesis of CAD, indicating the possible role in CAD diagnosis. The present study aimed to explore the expression profile of plasma miRNAs and estimate their value in diagnosis for CAD. 67 Non‐CAD control subjects and 88 CAD patients were enrolled. We conducted careful evaluation by RT‐PCR analysis, Spearman rank correlation coefficients analysis, Receiver Operating Characteristic (ROC) curves analysis and so on. The plasma levels of six miRNAs known to be related to CAD were measured and three of them showed obvious expression change. Circulating miR‐29a‐3p, miR‐574‐3p and miR‐574‐5p were all significantly increased. ROC analysis revealed the probability of the three miRNAs as biomarkers with AUCs (areas under the ROC curve) of 0.830, 0.792 and 0.789, respectively. They were significantly correlated with each other in CAD patients, suggesting the possibility of joint diagnosis. The combined AUC was 0.915, much higher than each single miRNA. Therefore, our study revealed three promising biomarkers for early diagnosis of CAD. The combination of these miRNAs may act more effectively than individual ones for CAD diagnosis. 相似文献