全文获取类型
收费全文 | 427篇 |
免费 | 17篇 |
国内免费 | 6篇 |
专业分类
450篇 |
出版年
2024年 | 2篇 |
2023年 | 12篇 |
2022年 | 9篇 |
2021年 | 17篇 |
2020年 | 16篇 |
2019年 | 17篇 |
2018年 | 9篇 |
2017年 | 5篇 |
2016年 | 16篇 |
2015年 | 15篇 |
2014年 | 18篇 |
2013年 | 34篇 |
2012年 | 13篇 |
2011年 | 18篇 |
2010年 | 14篇 |
2009年 | 20篇 |
2008年 | 28篇 |
2007年 | 19篇 |
2006年 | 16篇 |
2005年 | 15篇 |
2004年 | 15篇 |
2003年 | 11篇 |
2002年 | 12篇 |
2001年 | 5篇 |
2000年 | 8篇 |
1999年 | 9篇 |
1998年 | 8篇 |
1997年 | 7篇 |
1996年 | 13篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 6篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1971年 | 2篇 |
1958年 | 1篇 |
排序方式: 共有450条查询结果,搜索用时 0 毫秒
41.
Mehmet Karaca Burcu Hismi Riza Koksal Ozgul Sefayet Karaca Didem Yucel Yilmaz Turgay Coskun Hatice Serap Sivri Aysegul Tokatli Ali Dursun 《Gene》2014
Classical homocystinuria is the most commonly inherited disorder of sulfur metabolism, caused by the genetic alterations in human cystathionine beta-synthase (CBS) gene. In this study, we present comprehensive clinical findings and the genetic basis of homocystinuria in a cohort of Turkish patients. Excluding some CBS mutations, detailed genotype–phenotype correlation for different CBS mutations has not been established in literature. We aimed to make clinical subgroups according to main clinical symptoms and discussed these data together with mutational analysis results from our patients. Totally, 16 different mutations were identified; twelve of which had already been reported, and four are novel (p.N93Y, p.L251P, p.D281V and c.829−2A>T). The probands were classified into three major groups according to the clinical symptoms caused by these mutations. A psychomotor delay was the most common diagnostic symptom (n = 12, 46.2% neurological presentation), followed by thromboembolic events (n = 6, 23.1% vascular presentation) and lens ectopia, myopia or marfanoid features (n = 5, 19.2% connective tissue presentation). Pyridoxine responsiveness was 7.7%; however, with partial responsive probands, the ratio was 53.9%. 相似文献
42.
43.
44.
The present paper shows possible effects of antiretroviral treatment on the dynamics of the spread of the disease of human immunodeficiency virus infection in a population of varying size. By introducing time delays, we model the latency period and the delayed onset of positive treatment effects in the patients. The Hopf bifurcation and stability behaviour of the delay differential-equation model are analysed and simulations for different scenarios depending on the size of the treatment-induced delay are presented, and the results are discussed in detail. 相似文献
45.
A simple SIS epidemic model with a backward bifurcation 总被引:11,自引:0,他引:11
It is shown that an SIS epidemic model with a non-constant contact rate may have multiple stable equilibria, a backward bifurcation and hysteresis. The consequences for disease control are discussed. The model is based on a Volterra integral equation and allows for a distributed infective period. The analysis includes both local and global stability of equilibria. 相似文献
46.
Thomas Fournier Jean-Pierre Gabriel Christian Mazza Jerôme Pasquier José Galbete Nicolas Mermod 《Bulletin of mathematical biology》2009,71(6):1394-1431
Regulatory gene networks contain generic modules, like those involving feedback loops, which are essential for the regulation
of many biological functions (Guido et al. in Nature 439:856–860, 2006). We consider a class of self-regulated genes which are the building blocks of many regulatory gene networks, and study the
steady-state distribution of the associated Gillespie algorithm by providing efficient numerical algorithms. We also study
a regulatory gene network of interest in gene therapy, using mean-field models with time delays. Convergence of the related
time-nonhomogeneous Markov chain is established for a class of linear catalytic networks with feedback loops. 相似文献
47.
Early language development is known to be under genetic influence, but the genes affecting normal variation in the general population remain largely elusive. Recent studies of disorder reported that variants of the CNTNAP2 gene are associated both with language deficits in specific language impairment (SLI) and with language delays in autism. We tested the hypothesis that these CNTNAP2 variants affect communicative behavior, measured at 2 years of age in a large epidemiological sample, the Western Australian Pregnancy Cohort (Raine) Study. Singlepoint analyses of 1149 children (606 males and 543 females) revealed patterns of association which were strikingly reminiscent of those observed in previous investigations of impaired language, centered on the same genetic markers and with a consistent direction of effect (rs2710102, P = 0.0239; rs759178, P = 0.0248). On the basis of these findings, we performed analyses of four-marker haplotypes of rs2710102-rs759178-rs17236239-rs2538976 and identified significant association (haplotype TTAA, P = 0.049; haplotype CGAG, [corrected] P = .0014). Our study suggests that common variants in the exon 13-15 region of CNTNAP2 influence early language acquisition, as assessed at age 2, in the general population. We propose that these CNTNAP2 variants increase susceptibility to SLI or autism when they occur together with other risk factors. 相似文献
48.
A threshold parameter R
0 is identified for an SIRS epidemiological model which has nonlinear incidence and a distributed delay for transfer out of the removed class. For R
0 < 1, the disease free equilibrium is proved to be the global attractor for all solutions.Research supplied in part by NSERC A-8965 相似文献
49.
50.
Neetha John Moka Rajasekhar Katta Mohan Girisha Podila Satya Venkata Narasimha Sharma Puthiya Mundyat Gopinath 《Indian journal of human genetics》2013,19(2):165-170