Limited plasticity in the phenotypic variance‐covariance matrix for male advertisement calls in the black field cricket,Teleogryllus commodus

Phenotypic integration and plasticity are central to our understanding of how complex phenotypic traits evolve. Evolutionary change in complex quantitative traits can be predicted using the multivariate breeders’ equation, but such predictions are only accurate if the matrices involved are stable over evolutionary time. Recent study, however, suggests that these matrices are temporally plastic, spatially variable and themselves evolvable. The data available on phenotypic variance‐covariance matrix ( P ) stability are sparse, and largely focused on morphological traits. Here, we compared P for the structure of the complex sexual advertisement call of six divergent allopatric populations of the Australian black field cricket, Teleogryllus commodus. We measured a subset of calls from wild‐caught crickets from each of the populations and then a second subset after rearing crickets under common‐garden conditions for three generations. In a second experiment, crickets from each population were reared in the laboratory on high‐ and low‐nutrient diets and their calls recorded. In both experiments, we estimated P for call traits and used multiple methods to compare them statistically (Flury hierarchy, geometric subspace comparisons and random skewers). Despite considerable variation in means and variances of individual call traits, the structure of P was largely conserved among populations, across generations and between our rearing diets. Our finding that P remains largely stable, among populations and between environmental conditions, suggests that selection has preserved the structure of call traits in order that they can function as an integrated unit.     

Ethical issues associated with HIV phylogenetics in HIV transmission dynamics research: A review of the literature using the Emanuel Framework

The reduced costs of DNA sequencing and the use of such data for HIV‐1 clinical management and phylogenetic analysis have led to a massive increase of HIV‐1 sequences in the last few years. Phylogenetic analysis has shed light on the origin, spread and characteristics of HIV‐1 epidemics and outbreaks. Phylogenetic analysis is now also being used to advance our knowledge of the drivers of HIV‐1 transmission in order to design effective interventions. However, HIV phylogenetic analysis presents unique ethical challenges, which have not been fully explored. This review presents an analysis of what appear to be key ethical issues in HIV phylogenetics in the hope of stimulating further conceptual and empirical work in this rapidly emerging area. We structure the review using the Emanuel Framework, a systematic, holistic framework, which has been adapted for use in developing countries, which bear the brunt of the HIV‐1 pandemic.     

枇杷果实采后生理与保鲜技术研究进展(综述)

本文综述枇杷果实采后生理与保鲜技术的研究现状,并提出枇杷保鲜技术发展方向。     

Drugging the undruggable proteins in cancer: A systems biology approach

In recent years, the research community has, with comprehensive systems biology approaches and related technologies, gained insight into the vast complexity of numerous cancers. These approaches allow an in-depth exploration that cannot be achieved solely using conventional low-throughput methods, which do not closely mimic the natural cellular environment. In this review, we discuss recent integrative multiple omics approaches for understanding and modulating previously identified ‘undruggable’ targets such as members of the RAS family, MYC, TP53, and various E3 ligases and deubiquitinases. We describe how these technologies have revolutionized drug discovery by overcoming an array of biological and technological challenges and how, in the future, they will be pivotal in assessing cancer states in individual patients, allowing for the prediction and application of personalized disease treatments.     

Rehabilitating degraded forests in Central Europe into self–sustaining forest ecosystems

There is a need for a consistent forest restoration strategy for the `Black Triangle', Central Europe. In the past 50 years, forests in this area have been heavily affected by industrial pollution. Recently, the amount of pollutants has decreased. This means that effective forest restoration programmes can be started. Forest decline must be seen as an ecological disturbance which cannot be solved by applying technical measures only. An ecosystem approach to forest restoration must be introduced into restoration policy and management. Basic principles and working methods of such an approach are briefly described and proposals are made for forest restoration policy, management and research in the area.     

Research ethics capacity development in Africa: exploring a model for individual success

The Johns Hopkins-Fogarty African Bioethics Training Program (FABTP) has offered a fully-funded, one-year, non-degree training opportunity in research ethics to health professionals, ethics committee members, scholars, journalists and scientists from countries across sub-Saharan Africa. In the first 9 years of operation, 28 trainees from 13 African countries have trained with FABTP. Any capacity building investment requires periodic critical evaluation of the impact that training dollars produce. In this paper we describe and evaluate FABTP and the efforts of its trainees. Our data show that since 2001, the 28 former FABTP trainees have authored or co-authored 105 new bioethics-related publications; were awarded 33 bioethics-related grants; played key roles on 78 bioethics-related research studies; and participated in 198 bioethics workshops or conferences. Over the past nine years, trainees have collectively taught 48 separate courses related to bioethics and have given 170 presentations on various topics in the field. Many former trainees have pursued and completed doctoral degrees in bioethics; some have become editorial board members for bioethics journals. Female trainees were, on average, less experienced at matriculation and produced fewer post-training outputs than their male counterparts. More comprehensive studies are needed to determine the relationships between age, sex, previous experience and training program outputs.     

城市生态智慧管理系统的生态系统服务评估功能与应用

开展生态系统服务评估已经成为国土空间功能管治、城市治理、生态产品价值实现等工作中的先行基础动作。生态系统服务的类型和模型方法多,数据需求复杂,传统基于多学科软件开展生态系统服务评估的工作模式知识和技术门槛较高、效率低。当前专业的生态系统服务评估软件多为美国从业人员开发,对我国的数据构成和本地化参数适应性有限。介绍了我国自主开发的生态系统分析软件（城市生态智慧管理系统,IUEMS）的主要功能和应用情况,并将其的生态系统服务评估功能与InVEST、ARIES等国外主流软件在操作逻辑、评估模型、数据取得、空间精度、界面交互五个方面进行了对比。