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Toshihiko Kakiuchi Muneaki Matsuo Hiroyoshi Endo Yasuhisa Sakata Motohiro Esaki Takahiro Noda Ichiro Imamura Kazutoshi Hashiguchi Shinichi Ogata Yasuhiko Fujioka Keiichiro Hanada Kayoko Fukuda Masaya Yoshimura Tetsuro Kajiwara Kentaroh Yamamoto Daisuke Yamaguchi Hiroharu Kawakubo Taro Akashi Michihiro Sumino Keiji Matsunaga Eriko Muro Atsuo Kuwahara Kazuto Taniguchi Koji Fukuyama Akira Watanabe Ayako Takamori Masumi Okuda Kohei Yamanouchi Kazuma Fujimoto 《Helicobacter》2021,26(2):e12776
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We compared the efficacy of three antibiotics (ceftriaxone, erythromycin and clarithromycin) against Borrelia garinii infection in mice. The nymphal ticks of Ixodes persulcatus infected with the strain JEM6 of Japanese B. garinii were allowed to feed on female C3H mice. The mice were treated with each of the antibiotics for 5 consecutive days 1, 3, or 7 weeks after tick detachment. The doses of antibiotics per day were as follows: 5 mg intraperitoneal injection of ceftriaxone, 2 mg intraperitoneal injection of erythromycin and 1 mg peroral administration of clarithromycin. The infection status in treated mice was monitored by culturing their earlobes, hearts and urinary bladders in BSK II medium. Ceftriaxone eliminated borreliae completely; however, a recurrence of infection was observed in mice treated with erythromycin and clarithromycin. 相似文献
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