全文获取类型
收费全文 | 1739篇 |
免费 | 84篇 |
国内免费 | 47篇 |
出版年
2024年 | 3篇 |
2023年 | 35篇 |
2022年 | 43篇 |
2021年 | 42篇 |
2020年 | 76篇 |
2019年 | 79篇 |
2018年 | 82篇 |
2017年 | 84篇 |
2016年 | 105篇 |
2015年 | 71篇 |
2014年 | 50篇 |
2013年 | 352篇 |
2012年 | 50篇 |
2011年 | 39篇 |
2010年 | 32篇 |
2009年 | 46篇 |
2008年 | 44篇 |
2007年 | 49篇 |
2006年 | 43篇 |
2005年 | 47篇 |
2004年 | 36篇 |
2003年 | 32篇 |
2002年 | 23篇 |
2001年 | 29篇 |
2000年 | 18篇 |
1999年 | 14篇 |
1998年 | 20篇 |
1997年 | 18篇 |
1996年 | 24篇 |
1995年 | 16篇 |
1994年 | 17篇 |
1993年 | 12篇 |
1992年 | 12篇 |
1991年 | 18篇 |
1990年 | 28篇 |
1989年 | 21篇 |
1988年 | 19篇 |
1987年 | 18篇 |
1986年 | 17篇 |
1985年 | 28篇 |
1984年 | 18篇 |
1983年 | 12篇 |
1982年 | 17篇 |
1981年 | 7篇 |
1980年 | 3篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1974年 | 2篇 |
排序方式: 共有1870条查询结果,搜索用时 15 毫秒
61.
The incidence of diapause in the spider mite Tetranychus urticae was predicted for various photoperiodic regimes, according to the external coincidence model of photoperiodic time measurement. A phase response curve was constructed for the hypothetical photoperiodic oscillator in these mites: entrainment of this photoperiodic oscillator to a variety of ‘complete’ and ‘skeleton’ photoperiods was calculated using a transformation method for circadian rhythms. The external coincidence model proved adequate to describe experimental results with T. urticae in ‘complete’ photoperiods (T = 24 hr), symmetrical ‘skeleton’ photoperiods (T = 24 hr), asymmetrical ‘skeleton’ photoperiods (T = 24 hr) (night-interruption experiments), and ‘resonance’ experiments, in which the light component of a light/dark cycle was held constant at 8 hr and the dark component was varied over a wide range in successive experiments, providing cycles with period lengths up to 92 hr. The external coincidence model proved inadequate to explain results obtained in a ‘T-experiment’ with T. urticae comprising 1 hr pulses of light in a cycle of LD1:17.5 (T = 18.5 hr) with the first pulse of the train starting at different circadian phases. The validity and limitations of the external coincidence model as an explanation of photoperiodic time measurement in T. urticae are discussed in view of the above results. 相似文献
62.
《Current biology : CB》2020,30(16):3154-3166.e4
- Download : Download high-res image (207KB)
- Download : Download full-size image
63.
Nikkhil Velingkaar Volha Mezhnina Allan Poe Kuldeep Makwana Richa Tulsian Roman V. Kondratov 《Aging cell》2020,19(4)
Caloric restriction (CR) has positive effects on health and longevity. CR in mammals implements time‐restricted (TR) feeding, a short period of feeding followed by prolonged fasting. Periodic fasting, in the form of TR or mealtime, improves metabolism without reduction in caloric intake. In order to understand the relative contribution of reduced food intake and periodic fasting to the health benefits of CR, we compared physiological and metabolic changes induced by CR and TR (without reduced food intake) in mice. CR significantly reduced blood glucose and insulin around the clock, improved glucose tolerance, and increased insulin sensitivity (IS). TR reduced blood insulin and increased insulin sensitivity, but in contrast to CR, TR did not improve glucose homeostasis. Liver expression of circadian clock genes was affected by both diets while the mRNA expression of glucose metabolism genes was significantly induced by CR, and not by TR, which is in agreement with the minor effect of TR on glucose metabolism. Thus, periodic fasting contributes to some metabolic benefits of CR, but TR is metabolically different from CR. This difference might contribute to differential effects of CR and TR on longevity. 相似文献
64.
Artabotrys comprises a species-poor early divergent grade (EDG) and a main species-rich clade (“main Artabotrys clade,” MAC). All members of the MAC exhibit a remarkably well-conserved floral Bauplan characterized by a tightly enclosed floral chamber with an elaborate rim between the inner petal blade and claw. Conversely, EDG resembles the sister genus Xylopia in lacking the inner petal rim, with one species (Artabotrys brachypetalus) bearing petals that lack the distinction between blade and claw altogether. The floral phenology and pollination ecology of two exemplar species—Artabotrys brachypetalus from the EDG and Artabotrys blumei from the MAC—are compared, including assessment of effective pollinators and their activity patterns, scent chemistry and thermogenesis. Our study revealed that Artabotrys blumei exhibits abbreviated anthesis (c. 27 hr), with a floral phenology and morphology that are clearly consistent with pollinator trapping, and may be pollinated by small beetles. Artabotrys brachypetalus has a typical anthetic duration (c. 45 hr), lacks a pollinator trapping mechanism, and is pollinated by honey bees and curculionid beetles. The “xylopioid” traits of the EDG are likely to be plesiomorphic, whereas the tightly enclosed floral chamber is likely to be apomorphic for the MAC and functionally significant in trapping pollinators. 相似文献
65.
66.
67.
CONSTANS(CO)及CONSTANS-like(COL)基因在光周期调控植物开花中起到重要的作用。该研究以文心兰(Oncidium)品种‘金辉’为材料,分离了CO同源基因OnCOL2及另外2个COL基因(OnCOL8和OnCOL9),它们分别编码326、411和291个氨基酸;生物信息分析预测它们均定位于细胞核;OnCOL2、OnCOL8有2个锌指B-box结构域和1个CCT结构域,而OnCOL9缺少B-box结构域。多序列比对及进化树分析结果表明,所有COL蛋白可划分为3组,OnCOL2与OnCOL8、OnCOL9分到了2个不同组中。OnCOL2与建兰(Cymbidium ensifolium)CeCOL(90.77%)高度相似;OnCOL8与OnCOL9在进化关系上更为接近,分别与拟南芥(Arabidopsis thaliana)AtCOL9和AtCOL10关系最近,它们在B-box和CCT结构域都极为保守。表达分析结果表明OnCOL2、OnCOL8与OnCOL9分别在花、根和假鳞茎中表达量最高,在叶片中的表达呈周期性变化趋势,且在长、短日照条件下表达的峰值及时间均存在差异,在花芽分化时期的叶片中表达量均显著上调。研究表明,OnCOL2、OnCOL8与OnCOL9基因均受到生物钟和日长调节,在光周期途径中,可能通过上调它们的表达以促进文心兰花芽的形成。该研究结果为进一步研究基因功能及光周期调控文心兰开花机制奠定了基础。 相似文献
68.
69.
Binwen Liu Shuaishuai Chu Tiantian Liu Jia Song Zhengliang Ma 《Chronobiology international》2021,38(1):38-45
ABSTRACT The role of the serotonin 7 receptor (5-HT7 receptor) subtype in a number of domains has been widely recognized, but its role in the regulation of changes of the circadian rhythm after anesthesia is still unclear. We used intraperitoneal injection of 5-HT7 receptor agonist LP-211 or antagonist SB-269970 in mice to influence the level of 5-HT7 receptor protein in the SCN and to observe the role of this receptor on circadian rhythm changes after isoflurane anesthesia. Our results show the appropriate dose of SB-269970 significantly alleviated the circadian rhythm disorder induced by isoflurane anesthesia, while LP-211 significantly aggravated it after anesthesia, which is different from the phase shift that can be caused by the administration of LP-211 before anesthesia. These findings may indicate the 5-HT7 receptor plays a complex role in the regulation of circadian rhythm after anesthesia. Our findings may provide some positive significance for alleviating circadian rhythm disorder in patients after anesthesia and ultimately promoting rapid postoperative recovery. 相似文献