全文获取类型
收费全文 | 3773篇 |
免费 | 189篇 |
国内免费 | 264篇 |
出版年
2023年 | 36篇 |
2022年 | 55篇 |
2021年 | 123篇 |
2020年 | 82篇 |
2019年 | 82篇 |
2018年 | 91篇 |
2017年 | 74篇 |
2016年 | 67篇 |
2015年 | 102篇 |
2014年 | 184篇 |
2013年 | 258篇 |
2012年 | 180篇 |
2011年 | 138篇 |
2010年 | 118篇 |
2009年 | 156篇 |
2008年 | 149篇 |
2007年 | 160篇 |
2006年 | 190篇 |
2005年 | 159篇 |
2004年 | 153篇 |
2003年 | 165篇 |
2002年 | 165篇 |
2001年 | 156篇 |
2000年 | 150篇 |
1999年 | 101篇 |
1998年 | 107篇 |
1997年 | 83篇 |
1996年 | 89篇 |
1995年 | 73篇 |
1994年 | 63篇 |
1993年 | 59篇 |
1992年 | 52篇 |
1991年 | 35篇 |
1990年 | 43篇 |
1989年 | 39篇 |
1988年 | 40篇 |
1987年 | 44篇 |
1986年 | 20篇 |
1985年 | 21篇 |
1984年 | 34篇 |
1983年 | 11篇 |
1982年 | 15篇 |
1981年 | 20篇 |
1980年 | 17篇 |
1979年 | 21篇 |
1978年 | 17篇 |
1977年 | 9篇 |
1976年 | 6篇 |
1974年 | 4篇 |
1972年 | 3篇 |
排序方式: 共有4226条查询结果,搜索用时 15 毫秒
991.
Tim Connallon Erin Jakubowski 《Evolution; international journal of organic evolution》2009,63(8):2179-2183
Genetic variation can be beneficial to one sex yet harmful when expressed in the other—a condition referred to as sexual antagonism. Because X chromosomes are transmitted from fathers to daughters, and sexually antagonistic fitness variation is predicted to often be X-linked, mates of relatively low-fitness males might produce high-fitness daughters whereas mates of high-fitness males produce low-fitness daughters. Such fitness consequences have been predicted to influence the evolution of female mating biases and the offspring sex ratio. Females might evolve to prefer mates that provide good genes for daughters or might adjust offspring sex ratios in favor of the sex with the highest relative fitness. We test these possibilities in a laboratory-adapted population of Drosophila melanogaster , and find that females preferentially mate with males carrying genes that are deleterious for daughters. Preferred males produce equal numbers of sons and daughters, whereas unpreferred males produce female-biased sex ratios. As a consequence, mean offspring fitness of unpreferred males is higher than offspring fitness of preferred males. This observation has several interesting implications for sexual selection and the maintenance of population genetic variation for fitness. 相似文献
992.
Ponce R 《Genetica》2009,135(3):415-418
Gene families are composed of closely related genes and are an important part of eukaryotic genomes. In the proximal region
of the X chromosome of Drosophila melanogaster there is a cluster of four tandem Sdic genes, located between the gene Cdic and the gene AnnX. Sdic is a chimeric gene that encodes a novel protein with sperm-specific expression. It had been hypothesized that the Sdic gene cluster was formed after the split of D. melanogaster and D. simulans. To study the evolution of this cluster, the sequence of this region was studied in several Drosophilidae species. In all species analyzed, Sdic genes are absent and AnnX and Cdic are adjacent to each other. The results allowed the inference of the ancestral situation and the reconstruction of the evolution
of the cluster, and confirm that the Sdic cluster was indeed formed in the lineage that gave rise to D. melanogaster, being one of the youngest gene clusters known.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
993.
Residues of maternal nuclear DNA in the form of chromosome fragments were observed in the healthy and morphologically normal androgenetic rainbow trout Oncorhynchus mykiss. A hypothetical model for formation of chromosome re‐arrangements caused by the incomplete maternal nuclear DNA inactivation in the androgenetic rainbow trout was proposed in the present paper. 相似文献
994.
995.
Lucy Remnant Natalia Y. Kochanova Caitlin Reid Fernanda Cisneros-Soberanis William C. Earnshaw 《Open biology》2021,11(8)
Ki-67 is one of the most famous marker proteins used by histologists to identify proliferating cells. Indeed, over 30 000 articles referring to Ki-67 are listed on PubMed. Here, we review some of the current literature regarding the protein. Despite its clinical importance, our knowledge of the molecular biology and biochemistry of Ki-67 is far from complete, and its exact molecular function(s) remain enigmatic. Furthermore, reports describing Ki-67 function are often contradictory, and it has only recently become clear that this proliferation marker is itself dispensable for cell proliferation. We discuss the unusual organization of the protein and its mRNA and how they relate to various models for its function. In particular, we focus on ways in which the intrinsically disordered structure of Ki-67 might aid in the assembly of the still-mysterious mitotic chromosome periphery compartment by controlling liquid–liquid phase separation of nucleolar proteins and RNAs. 相似文献
996.
宜昌百合根尖染色体C-带分析 总被引:1,自引:0,他引:1
利用Giemsa C-带方法对宜昌百合(Lilium leucanthum(Baker) Baker)进行研究。结果表明:宜昌百合(L. leucanthum)的染色体数目为2n=2x=24,单套染色体的条带总数目为21条。其带型公式为:2n=24=6C+2CI+2I+2CI++2CI++4I++2I++2T++2I+S。宜昌百合(L. leucanthum)每条染色体上都显示出显著的特征带,且带纹的深浅差异明显。宜昌百合(L. leucanthum)的强带主要集中在着丝点及附近区域。通过Giemsa C-带方法可以将宜昌百合(L. leucanthum)的每条染色体区分开。 相似文献
997.
998.
中国地方黄牛的Y染色体遗传多样性及其进化起源 总被引:2,自引:1,他引:1
中国黄牛的进化起源与遗传多样性一直是国内外动物遗传学家感兴趣的课题之一.本文主要从Y染色体的形态多样性和Y染色体特异性微卫星标记遗传多态性两个方面对中国地方黄牛的遗传多样性和进化起源进行了综述.中国地方黄牛Y染色体具有中着丝粒、亚中着丝粒和近端着丝粒3种类型,这说明中国地方黄牛起源于普通牛和瘤牛.利用Y染色体特异性微卫星标记对中国地方黄牛Y染色体单倍型分布特征及Y染色体基因流模式的分析表明,北方种群中普通牛单倍型频率最高,瘤牛单倍型在南方种群中占优势;在中国不同地域,瘤牛Y染色体单倍型频率呈现自南而北、自东而西逐渐降低的趋势,这再次证实了中国黄牛主要来源于普通牛和瘤牛,这可能是这两类牛群在长期的历史进化过程中,分别从东南方向和西北方向进入我国,并在中原地区汇合的结果.本文为中国地方黄牛品种资源保护和杂交育种工作提供了参考依据. 相似文献
999.
1000.
目的:研究西洋参(Panax quinguefolium L)抗突变作用和对细胞增殖的影响.方法:采用小鼠骨髓淋巴细胞有丝分裂指数试验、染色体畸变试验和微核试验,观察西洋参对小鼠骨髓淋巴细胞遗传损伤效应的影响.结果:丝裂霉素(Mitomycin-c MMC)单独作用时,能抑制小鼠骨髓淋巴细胞的增殖(P<0.01),提高小鼠骨髓淋巴细胞的染色体突变(P<0.01)和微核率(P<0.01).西洋参高、中、低剂量组与MMC联合作用时,有丝分裂指数明显比模型组提高(P<0.01),并且均能显著地抑制由于MMC引起的染色体突变,其抑制率分别为68.25%、34.97%和14.29%,同时对MMC诱发的微核率也有明显的抑制效应.结论:西洋参能抑制MMC诱发的染色体畸变率和微核率,促进细胞的增殖能力. 相似文献