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Lara M. Boyle 《The Yale journal of biology and medicine》2013,86(2):117-125
Chronic stress plays a role in the etiology of several affective and
anxiety-related disorders. Despite this, its mechanistic effects on the brain
are still unclear. Of particular interest is the effect of chronic stress on the
amygdala, which plays a key role in the regulation of emotional responses and
memory consolidation. This review proposes a neuroplasticity model for the
effects of chronic stress in this region, emphasizing the roles of glutamate and
BDNF signaling. This model provides a review of recent discoveries of the
effects of chronic stress in the amygdala and reveals pathways for future
research. 相似文献