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71.
Schad J Ganzhorn JU Sommer S 《Evolution; international journal of organic evolution》2005,59(2):439-450
We investigated the importance of the major histocompatibility complex (MHC) constitution on the parasite burden of free-ranging mouse lemurs (Microcebus murinus) in four littoral forest fragments in southeastern Madagascar. Fourteen different MHC class II DRB-exon 2 alleles were found in 228 individuals with high levels of sequence divergence between alleles. More nonsynonymous than synonymous substitutions in the functional important antigen recognition and binding sites indicated selection processes maintaining MHC polymorphism. Animals from the four forest fragments differed in their infection status (being infected or not), in the number of different nematode morphotypes per individual (NNI) as well as in the fecal egg counts (FEC) values. Heterozygosity in general was uncorrelated with any of these measures of infection. However, a positive relationship was found between specific alleles and parasite load. Whereas the common allele Mimu-DRB*1 was more frequently found in infected individuals and in individuals with high NNI and FEC values (high parasite load), the rare alleles Mimu-DRB*6 and 10 were more prevalent in uninfected individuals and in individuals with low NNI and FEC values (low parasite load). These three alleles associated with parasite load had unique amino acid motifs in the antigen binding sites. This distinguished them from the remaining 11 Mimu-DRB alleles. Our results support the hypothesis that MHC polymorphism in M. murinus is maintained through pathogen-driven selection acting by frequency-dependent selection. This is the first study of the association of MHC variation and parasite burden in a free-ranging primate. 相似文献
72.
Primate spermatogenesis: new insights into comparative testicular organisation, spermatogenic efficiency and endocrine control 总被引:2,自引:0,他引:2
Luetjens CM Weinbauer GF Wistuba J 《Biological reviews of the Cambridge Philosophical Society》2005,80(3):475-488
Owing to the close phylogenetic relationship of Platyrrhini (New World monkeys) and Catarrhini (Old World monkeys) to man, nonhuman primates are often used as models for the study of male reproductive physiology and endocrinology. This review aims at providing new data and insights into comparative primate spermatogenesis, dealing specifically with quantitative aspects of germinal epithelial organisation and germ cell production, and with the roles of gonadotrophic hormones in this process. Typically, the seminiferous epithelium is composed of specific germ cell associations (spermatogenic stages). In rodents, prosimians and most Catarrhini, tubular cross sections contain a single spermatogenic stage whereas in Platyrrhini, great apes and man multi-stage tubules are present. Since Platyrrhini represent a more basal type of primate, this spermatogenic feature must have developed convergently. The primate multi-stage tubular arrangement was previously believed to be associated with low spermatogenic efficiency. However, recent studies using new methodological approaches and comparing primate species from all taxa have revealed that multistage organisation is compatible with highly efficient spermatogenesis. In fact, meta-analysis demonstrated that the efficiency of spermatogenesis in several nonhuman primate species is comparable to that of rodents which are considered as species with highly efficient germ cell production. The duration of the spermatogenic process was not related to organisation or efficiency of spermatogenesis. Sertoli cell work load was species-specific but had no impact on germ cell numbers and on the efficiency of spermatogenesis. The gonadotrophic hormones, luteinizing hormone (LH) and follicle stimulating hormone (FSH) are the primary regulators of primate testicular function. Recent studies revealed that in New World monkeys chorionic gonadotrophin (CG)--the primate pregnancy hormone--regulates testosterone production instead of LH. Receptor studies demonstrated a dual action of the closely related hormones LH and CG in primates. It is hypothesised that following the divergence of the Platyrrhini lineage from Catarrhini, the LH/CG system evolved independently with ancestral functions of the LH/CG system retained in the neotropical taxa. In summary, key spermatogenic features are preserved across all primate taxa whereas male reproductive endocrinology features appear substantially different in the neotropical primates compared to other primate lineages. 相似文献
73.
The Chassahowitzka, Homosassa and Crystal rivers along the central Gulf coast of Florida were studied from 1998 to 2000 to identify factors controlling the abundance and distribution of submersed aquatic vegetation (SAV). Each of these three low-lying coastal rivers are spring-fed and exhibit low to moderate absolute flow rates (flows in either direction because of tidal influences, 0.06–0.46ms–1) with only 14 of the stations sampled for SAV having flow rates in excess of 0.25ms–1. At those stations where flow rates exceeded 0.25ms–1, the substrate was generally comprised of exposed limestone outcroppings and did not provide a favorable habitat for either submersed macrophytes or macroalgae. The remaining sampling stations, where flow rates were less than 0.25ms–1, had suitable substrates (e.g. mud, mud/sand, and sand) for the colonization and subsequent growth of SAV. Light availability and salinity were determined to be major factors affecting the distribution and abundance of SAV. Sampling stations, where the percent of incident light at the surface reaching the substrate was less than 10, had little or no SAV biomass. Low SAV biomass was also linked to sites where annual average salinities exceeded 3.5. Nutrient loads and nutrient concentrations accounted for little variance in SAV biomass after accounting for flow and related substrate type, light and salinity. These latter factors control the distribution and abundance of SAV in these three Florida coastal rivers. 相似文献
74.
Bjrn Grüneberg Jacqueline Rücker Brigitte Nixdorf Horst Behrendt 《International Review of Hydrobiology》2011,96(5):599-621
Based on measured and calculated long‐term data on external phosphorus (P) load (1920–2009), hypolimnetic P accumulation and trophic parameters for the dimictic Lake Scharmützelsee, we aimed to identify factors which cause variable P net sedimentation and the importance of internal P loading for different time periods especially focusing on non‐steady state after abrupt external load reduction in 1988. P retention (R) decreased from 0.85 during the high external P loading (0.37 g m–2 a–1) phase (1950–1988) to 0.71 during the following transient phase, and increased to 0.81 for the present recovery phase (0.17 g m–2 a–1) beginning in 2003. Mean net sedimentation coefficients for the same periods were 0.47, 0.22 and 0.30. Our results show that a) empirical models overestimate R during the high loading phase and underestimate R during the transient phase after load reduction, and b) the application of simple one‐box models which assume that a portion of in‐lake P stock is retained requires the consideration of the variability of the net sedimentation coefficient. We identified multiple reasons for variable gross sedimentation (e.g., particle trapping in the elongated lake; efficient accumulation of sewage P) as well as release of P (delayed release of mobile P from sediment; changes in plant colonization and food webs), so that their relation (net sedimentation) varies. Despite a new equilibrium reached in 2003, it is still unclear when the lake will reach mesotrophic reference conditions and a good ecological status. Historical data and elevated Cl– concentration (22 mg L–1) indicate that P import from sewage contaminated groundwater still continues, so that the mean in‐lake P concentration is still too high (53 µg L–1), and biological structures have not fully recovered yet. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
75.
An important issue in conservation biology and the study of evolution is the extent to which inbreeding depression can be reduced or reversed by natural selection. If the deleterious recessive alleles causing inbreeding depression can be 'purged' by natural selection, outbred populations that have a history of inbreeding are expected to be less susceptible to inbreeding depression. This expectation, however, has not been realized in previous laboratory experiments. In the present study, we used Drosophila melanogaster as a model system to test for an association between inbreeding history and inbreeding depression. We created six 'purged' populations from experimental lineages that had been maintained at a population size of 10 male-female pairs for 19 generations. We then measured the inbreeding depression that resulted from one generation of full-sib mating in the purged populations and in the original base population. The magnitude of inbreeding depression in the purged populations was approximately one-third of that observed in the original base population. In contrast to previous laboratory experiments, therefore, we found that inbreeding depression was reduced in populations that have a history of inbreeding. The large purging effects observed in this study may be attributable to the rate of historical inbreeding examined, which was slower than that considered in previous experiments. 相似文献
76.
N. H. Barton 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2010,365(1552):2559-2569
The prevalence of recombination in eukaryotes poses one of the most puzzling questions in biology. The most compelling general explanation is that recombination facilitates selection by breaking down the negative associations generated by random drift (i.e. Hill–Robertson interference, HRI). I classify the effects of HRI owing to: deleterious mutation, balancing selection and selective sweeps on: neutral diversity, rates of adaptation and the mutation load. These effects are mediated primarily by the density of deleterious mutations and of selective sweeps. Sequence polymorphism and divergence suggest that these rates may be high enough to cause significant interference even in genomic regions of high recombination. However, neither seems able to generate enough variance in fitness to select strongly for high rates of recombination. It is plausible that spatial and temporal fluctuations in selection generate much more fitness variance, and hence selection for recombination, than can be explained by uniformly deleterious mutations or species-wide selective sweeps. 相似文献
77.
Janna L. Fierst Thomas F. Hansen 《Evolution; international journal of organic evolution》2010,64(3):675-693
The Bateson–Dobzhansky–Muller model predicts that postzygotic isolation evolves due to the accumulation of incompatible epistatic interactions, but few studies have quantified the relationship between genetic architecture and patterns of reproductive divergence. We examined how the direction and magnitude of epistatic interactions in a polygenic trait under stabilizing selection influenced the evolution of hybrid incompatibilities. We found that populations evolving independently under stabilizing selection experienced suites of compensatory allelic changes that resulted in genetic divergence between populations despite the maintenance of a stable, high‐fitness phenotype. A small number of loci were then incompatible with multiple alleles in the genetic background of the hybrid and the identity of these incompatibility loci changed over the evolution of the populations. For F1 hybrids, reduced fitness evolved in a window of intermediate strengths of epistatic interactions, but F2 and backcross hybrids evolved reduced fitness across weak and moderate strengths of epistasis due to segregation variance. Strong epistatic interactions constrained the allelic divergence of parental populations and prevented the development of reproductive isolation. Because many traits with varying genetic architectures must be under stabilizing selection, our results indicate that polygenetic drift is a plausible hypothesis for the evolution of postzygotic reproductive isolation. 相似文献
78.
We investigated the influence of the polyunsaturated docosahexaenoic acid (22:6n-3; DHA) on the constitutive expression of choline acetyltransferase (ChAT) in native and induced expression in differentiated cholinergic cells NG108-15 grown in serum-free medium. Elimination of serum-derived trophic support resulted in growth arrest and a strong decrease of ChAT activity. In either conditions, DHA largely rescued general indicators of cell growth and function, and partially prevented the decrease of ChAT activity. However, the maximal effect on general cell state in native and differentiated cells, and ChAT activity in native cells, was reached at or below 10 μmol/l of DHA. In contrast, maximal induction of ChAT activity in differentiated cells required about six times higher concentrations of DHA. These data thus demonstrate stimulatory effect of DHA on ChAT activity that is independent of its general cell protective properties. 相似文献
79.
During 1999–2001 the chemical composition and fluxes were measured in rainfall, throughfall, soil solution and stream water
in a remote forested site in the Italian Alps. The analysis of temporal patterns revealed the differential behaviour of nitrogen
and sulphur and suggested that different mechanisms controlled their flux. No important changes in sulphate concentration
and fluxes emerged as the solution passed through the various components of the forest ecosystem, and temporal variations
of SO4 in the soil solution and stream were likely driven by the physical process of dilution. The availability of nitrate and ammonia,
by contrast, was drastically reduced as throughfall water entered the soil and passed through the mineral layers, irrespective
of season. The calculated hydrochemical budget based on throughfall and soil solution N fluxes revealed that ~80% N retention
in the forest soil, corresponding to 12 kg ha−1 yr−1, despite a relatively high N deposition loading (15 kg ha−1 yr−1). Most of the leached nitrogen (90%) was in the organic form. Indicators of the N status of this ecosystem, such as C/N ratio
in solid and solution phase of the soil and N foliage content as well as land use history were examined. Despite the strong
N retention in the forested part of the catchment, the stream water N–NO3 levels were consistently above 10 μg l−1 suggesting that the Val Masino catchment as a whole was less efficient in processing atmospheric N inputs. This contrasting
N behaviour illustrates the role of landscape features, such as the soil cover and vegetation type, that is characteristic
of an alpine catchment. 相似文献
80.
Sulphate-mediated phosphorus mobilization in riverine sediments at increasing sulphate concentration, River Spree, NE Germany 总被引:2,自引:0,他引:2
The study focuses on the response of a sulphate rich lowland river (River Spree) to a further increase in sulphate concentration as a result of mining activities in its catchments. It was hypothesized that riverine sediments could be conservative against an increase in sulphate concentration relating to both the intensity of sulphate reduction and the accompanying P mobilization. The usually lower amount of organic matter, compared to lakes or wetlands, and the high contents of iron oxides in the Spree sediment from discharged mining waters should counteract an enhanced P mobilization. Three short-term incubation experiments were carried out to test the sensitivity of different sediment horizons (0–10, 10–20 and 20–30 cm), the influence of temperature (5 and 25 °C) and the effect of a rising sulphate concentration (2.6–7.8 mM) on P mobilization rates (PMR) and sulphate reduction rates (SRR). Contrary to our initial hypothesis sulphate played a key role for P mobilization in riverine sediments because (1) all sulphate treated horizons showed a significant increase in pore water P concentrations, (2) increasing sulphate concentrations led to rising SRR and PMR, (3) the highest response on sulphate-mediated P mobilization was observed by a temperature enhancement of 20 °C. PMR increased one order of magnitude at all tested sulphate concentrations, but these increases in PMR only slightly effected the P concentrations in the overlying water. In conclusions, an increase of internal P load is only expected in case of doubling the recent in situ sulphate concentrations, but extended warm periods as an effect of climate change or increasing temperature, respectively, could be of more importance. 相似文献