全文获取类型
收费全文 | 4946篇 |
免费 | 474篇 |
国内免费 | 261篇 |
出版年
2024年 | 17篇 |
2023年 | 283篇 |
2022年 | 243篇 |
2021年 | 447篇 |
2020年 | 357篇 |
2019年 | 293篇 |
2018年 | 272篇 |
2017年 | 190篇 |
2016年 | 191篇 |
2015年 | 222篇 |
2014年 | 301篇 |
2013年 | 252篇 |
2012年 | 236篇 |
2011年 | 233篇 |
2010年 | 204篇 |
2009年 | 266篇 |
2008年 | 250篇 |
2007年 | 211篇 |
2006年 | 143篇 |
2005年 | 111篇 |
2004年 | 95篇 |
2003年 | 128篇 |
2002年 | 82篇 |
2001年 | 80篇 |
2000年 | 78篇 |
1999年 | 57篇 |
1998年 | 52篇 |
1997年 | 52篇 |
1996年 | 58篇 |
1995年 | 27篇 |
1994年 | 32篇 |
1993年 | 28篇 |
1992年 | 34篇 |
1991年 | 26篇 |
1990年 | 13篇 |
1989年 | 20篇 |
1988年 | 15篇 |
1987年 | 12篇 |
1986年 | 9篇 |
1985年 | 23篇 |
1984年 | 5篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1973年 | 2篇 |
排序方式: 共有5681条查询结果,搜索用时 15 毫秒
81.
H. Keith Massel Salvador Macias Darlene M. Meador Duane M. Rumbaugh 《International journal of primatology》1981,2(1):9-17
Twenty-month-old rhesus monkeys were tested in a modified discrimination-reversal paradigm, which was designed to distinguish
abstract learning from stimulus-response associational learning. Previous studies indicate that talapoin monkeys learn associationally
and great apes via forming abstract concepts. Adult rhesus monkeys are apparently capable of forming simple abstractions,
but learn primarily through associational process. The results of this study show the adolescent rhesus monkeys to be associational
learners, with their response patterns indicating more complexity than the talapoins but less than the adult rhesus monkeys.
The data suggest that rhesus monkeys develop their low-level capacity of abstract learning with maturation. 相似文献
82.
Rat fetuses exposed to an odor stimulus and an aversive stimulus in utero showed an aversion to the odor when tested 16 days postnatally. Fetuses that also received 80 μg/kg Met-enkephalin showed a greater aversion to the odor stimulus than those subjects that did not receive the peptide. The difference between these groups was marginally significant. Control subjects did not show an aversion. But, subjects exposed to the odor and Met-enkephalin without the aversive stimulus, when tested, showed a significant preference for the odor over other control groups. These data show that associative learning in rat fetuses at 20 days of gestation may be enhanced by administration of Met-enkephalin. 相似文献
83.
84.
85.
Hirotaka Shoji Hideo Hagihara Keizo Takao Satoko Hattori Tsuyoshi Miyakawa 《Journal of visualized experiments : JoVE》2012,(60)
Forced alternation and left-right discrimination tasks using the T-maze have been widely used to assess working and reference memory, respectively, in rodents. In our laboratory, we evaluated the two types of memory in more than 30 strains of genetically engineered mice using the automated version of this apparatus. Here, we present the modified T-maze apparatus operated by a computer with a video-tracking system and our protocols in a movie format. The T-maze apparatus consists of runways partitioned off by sliding doors that can automatically open downward, each with a start box, a T-shaped alley, two boxes with automatic pellet dispensers at one side of the box, and two L-shaped alleys. Each L-shaped alley is connected to the start box so that mice can return to the start box, which excludes the effects of experimenter handling on mouse behavior. This apparatus also has an advantage that in vivo microdialysis, in vivo electrophysiology, and optogenetics techniques can be performed during T-maze performance because the doors are designed to go down into the floor. In this movie article, we describe T-maze tasks using the automated apparatus and the T-maze performance of α-CaMKII+/- mice, which are reported to show working memory deficits in the eight-arm radial maze task. Our data indicated that α-CaMKII+/- mice showed a working memory deficit, but no impairment of reference memory, and are consistent with previous findings using the eight-arm radial maze task, which supports the validity of our protocol. In addition, our data indicate that mutants tended to exhibit reversal learning deficits, suggesting that α-CaMKII deficiency causes reduced behavioral flexibility. Thus, the T-maze test using the modified automatic apparatus is useful for assessing working and reference memory and behavioral flexibility in mice. 相似文献
86.
87.
Zhihui Deng Jianxin Zhen Genelle F Harrison Guobin Zhang Rui Chen Ge Sun Qiong Yu Neda Nemat-Gorgani Lisbeth A Guethlein Liumei He Mingzhong Tang Xiaojiang Gao Siqi Cai William H Palmer Jonathan A Shortt Christopher R Gignoux Mary Carrington Hongyan Zou Peter Parham Wenxu Hong Paul J Norman 《Molecular biology and evolution》2021,38(6):2582
Human natural killer (NK) cells are essential for controlling infection, cancer, and fetal development. NK cell functions are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA-A, -B, and -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand and contribute to reproduction and immunity. In contrast, only some HLA-A and -B alleles encode KIR ligands and they focus on immunity. By high-resolution analysis of KIR and HLA-A, -B, and -C genes, we show that the Chinese Southern Han (CHS) are significantly enriched for interactions between inhibitory KIR and HLA-A and -B. This enrichment has had substantial input through population admixture with neighboring populations, who contributed HLA class I haplotypes expressing the KIR ligands B*46:01 and B*58:01, which subsequently rose to high frequency by natural selection. Consequently, over 80% of Southern Han HLA haplotypes encode more than one KIR ligand. Complementing the high number of KIR ligands, the CHS KIR locus combines a high frequency of genes expressing potent inhibitory KIR, with a low frequency of those expressing activating KIR. The Southern Han centromeric KIR region encodes strong, conserved, inhibitory HLA-C-specific receptors, and the telomeric region provides a high number and diversity of inhibitory HLA-A and -B-specific receptors. In all these characteristics, the CHS represent other East Asians, whose NK cell repertoires are thus enhanced in quantity, diversity, and effector strength, likely augmenting resistance to endemic viral infections. 相似文献
88.
89.
90.
《Structure (London, England : 1993)》2020,28(7):858-869.e3
- Download : Download high-res image (278KB)
- Download : Download full-size image