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991.
Schulte-Hostedde AI Millar JS Gibbs HL 《Evolution; international journal of organic evolution》2002,56(12):2519-2529
Sexual size dimorphism is ultimately the result of independent, sex-specific selection on body size. In mammals, male-biased sexual size dimorphism is the predominant pattern, and it is usually attributed to the polygynous mating system prevalent in most mammals. This sole explanation is unsatisfying because selection acts on both sexes simultaneously, therefore any explanation of sexual size dimorphism should explain why one sex is relatively large and the other is small. Using mark-recapture techniques and DNA microsatellite loci to assign parentage, we examined sex-specific patterns of annual reproductive success and survival in the yellow-pine chipmunk (Tamias amoenus), a small mammal with female-biased sexual size dimorphism, to test the hypothesis that the dimorphism was related to sex differences in the relationship between body size and fitness. Chipmunks were monitored and body size components measured over three years in the Kananaskis Valley, Alberta, Canada. Male reproductive success was independent of body size perhaps due to trade-offs in body size associated with behavioral components of male mating success: dominance and running speed. Male survival was consistent with stabilizing selection for overall body size and body size components. The relationship between reproductive success and female body size fluctuated. In two of three years the relationship was positive, whereas in one year the relationship was negative. This may have been the result of differences in environmental conditions among years. Large females require more energy to maintain their soma than small females and may be unable to maintain lactation in the face of challenging environmental conditions. Female survival was positively related to body size, with little evidence for stabilizing selection. Sex differences in the relationship between body size and fitness (reproductive success and survival) were the result of different processes, but were ultimately consistent with female-biased sexual size dimorphism evident in this species. 相似文献
992.
为探究水位变化对黑斑侧褶蛙(Pelophylaxnigromaculatus)蝌蚪形态表型、免疫功能和应激反应能力的影响,实验室内测定了水位恒定组以及水位快速、中速和慢速下降组37期蝌蚪发育至变态完成期的变态时长、身体大小和血液中各型白细胞的百分比,以及嗜中性粒细胞与淋巴细胞比值的变化。结果表明,水位快速下降显著缩短了蝌蚪的变态时长(P <0.05),体长下降明显(P <0.05),体重和体宽有所降低,但组间差异不显著(P> 0.05)。嗜中性粒细胞的百分比快速下降组显著高于其他处理组,单核细胞的百分比水位恒定组显著高于中速下降组(P <0.05),嗜酸性粒细胞、嗜碱性粒细胞和淋巴细胞的百分比均无明显的组间差异(P>0.05);嗜中性粒细胞与淋巴细胞比值快速下降组显著高于其他处理组(P <0.05)。水位加速下降导致登陆后幼蛙的个体变小,由嗜中性粒细胞和单核细胞所代表的天然免疫能力变化趋势不同,应激反应能力增强,可能不利于幼蛙的存活。 相似文献
993.
Lavanya Balakrishnan Raja Sekhar Nirujogi Sartaj Ahmad Mitali Bhattacharjee Srikanth S Manda Santosh Renuse Dhanashree S Kelkar Yashwanth Subbannayya Rajesh Raju Renu Goel Joji Kurian Thomas Navjyot Kaur Mukesh Dhillon Shantal Gupta Tankala Ramesh Jois Vivek Vasdev YL Ramachandra Nandini A Sahasrabuddhe TS Keshava Prasad Sujatha Mohan Harsha Gowda Subramanian Shankar Akhilesh Pandey 《Clinical proteomics》2014,11(1):6
Background
Osteoarthritis is a chronic musculoskeletal disorder characterized mainly by progressive degradation of the hyaline cartilage. Patients with osteoarthritis often postpone seeking medical help, which results in the diagnosis being made at an advanced stage of cartilage destruction. Sustained efforts are needed to identify specific markers that might help in early diagnosis, monitoring disease progression and in improving therapeutic outcomes. We employed a multipronged proteomic approach, which included multiple fractionation strategies followed by high resolution mass spectrometry analysis to explore the proteome of synovial fluid obtained from osteoarthritis patients. In addition to the total proteome, we also enriched glycoproteins from synovial fluid using lectin affinity chromatography.Results
We identified 677 proteins from synovial fluid of patients with osteoarthritis of which 545 proteins have not been previously reported. These novel proteins included ADAM-like decysin 1 (ADAMDEC1), alanyl (membrane) aminopeptidase (ANPEP), CD84, fibulin 1 (FBLN1), matrix remodelling associated 5 (MXRA5), secreted phosphoprotein 2 (SPP2) and spondin 2 (SPON2). We identified 300 proteins using lectin affinity chromatography, including the glycoproteins afamin (AFM), attractin (ATRN), fibrillin 1 (FBN1), transferrin (TF), tissue inhibitor of metalloproteinase 1 (TIMP1) and vasorin (VSN). Gene ontology analysis confirmed that a majority of the identified proteins were extracellular and are mostly involved in cell communication and signaling. We also confirmed the expression of ANPEP, dickkopf WNT signaling pathway inhibitor 3 (DKK3) and osteoglycin (OGN) by multiple reaction monitoring (MRM) analysis of osteoarthritis synovial fluid samples.Conclusions
We present an in-depth analysis of the synovial fluid proteome from patients with osteoarthritis. We believe that the catalog of proteins generated in this study will further enhance our knowledge regarding the pathophysiology of osteoarthritis and should assist in identifying better biomarkers for early diagnosis. 相似文献994.
Tero T. Mkinen Dsire Gavhed Ingvar Holmr Hannu Rintamki 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》2001,128(4)
The effects of exercise intensity on thermoregulatory responses in cold (−10°C) in a 0.2 (still air, NoWi), 1.0 (Wi1), and 5.0 (Wi5) m s−1 wind were studied. Eight young and healthy men, preconditioned in thermoneutral (+20°C) environment for 60 min, walked for 60 min on the treadmill at 2.8 km/h with different combinations of wind and exercise intensity. Exercise level was adjusted by changing the inclination of the treadmill between 0° (lower exercise intensity, metabolic rate 124 W m−2, LE) and 6° (higher exercise intensity, metabolic rate 195 W m−2, HE). Due to exercise increased heat production and circulatory adjustments, the rectal temperature (Tre), mean skin temperature (Tsk) and mean body temperature (Tb) were significantly higher at the end of HE in comparison to LE in NoWi and Wi1, and Tre and Tb also in Wi5. Tsk and Tb were significantly decreased by 5.0 m s−1 wind in comparison to NoWi and Wi1. The higher exercise intensity was intense enough to diminish peripheral vasoconstriction and consequently the finger skin temperature was significantly higher at the end of HE in comparison to LE in NoWi and Wi1. Mean heat flux from the skin was unaffected by the exercise intensity. At LE oxygen consumption (V
2) was significantly higher in Wi5 than NoWi and Wi1. Heart rate was unaffected by the wind speed. The results suggest that, with studied exercise intensities, produced without changes in walking speed, the metabolic rate is not so important that it should be taken into consideration in the calculation of wind chill index. 相似文献
995.
Healthier or bigger? Trade‐off mediating male dimorphism in the black scavenger fly Sepsis thoracica (Diptera: Sepsidae) 下载免费PDF全文
1. Life history trade‐offs emerge when limited resources are allocated to multiple functions of an organism. Under highly competitive conditions trade‐offs can result in alternative phenotypes that differ morphologically and physiologically. Such is the case in insect species that grow under high densities, where competition for resources but also the risk of disease contagion is high, prompting important adjustments in immune response and melanic cuticular pigmentation, with consequent sacrifices in other fitness‐related traits. 2. In the present study, the potential trade‐offs between total‐ and active phenoloxidase (PO), body size and body pigmentation in Sepsis thoracica black scavenger flies that show alternative male morphs differing in cuticular pigmentation, and body size were evaluated. 3. As expected, small/dark (obsidian) males showed higher total‐PO activity than larger/orange (amber) males. A negative relationship was found between total‐PO activity and body size in females and obsidian but not amber males, suggesting that growth and immunity are more costly for the former. In contrast, density did not affect PO activity, as predicted by the density‐dependent prophylaxis hypothesis, which had not been tested in dipterans before. However, rearing density did affect the body size negatively in females and amber but not obsidian males, showing that male morph is largely determined by condition‐dependent plasticity rather than genes. 4. This study provides good evidence that trade‐offs between different life‐history traits can result in alternative resource allocation strategies, even within one species. These strategies can produce strikingly different alternative phenotypes, evincing that there is not only one optimal solution to address fitness optimisation. 相似文献
996.
Sex differences in running economy (gross oxygen cost of running, CR), maximal oxygen uptake (VO2max), anaerobic threshold (Than), percentage utilization of aerobic power (% VO2max), and Than during running were investigated. There were six men and six women aged 20–30 years with a performance time of 2 h 40 min over the marathon distance. The VO2max, Than, and CR were measured during controlled running on a treadmill at 1° and 3° gradient. From each subject's recorded time of running in the marathon, the average speed (v
M) was calculated and maintained during the treadmill running for 11 min. The VO2 max was inversely related to body mass (m
b), there were no sex differences, and the mean values of the reduced exponent were 0.65 for women and 0.81 for men. These results indicate that for running the unit ml·kg–0.75·min–1 is convenient when comparing individuals with different m
b. The VO2max was about 10% (23 ml·kg–0.75·min–1) higher in the men than in the women. The women had on the average 10–12 ml·kg–0.75·min–1 lower VO2 than the men when running at comparable velocities. Disregarding sex, the mean value of CR was 0.211 (SEM 0.005) ml·kg–1·m–1 (resting included), and was independent of treadmill speed. No sex differences in Than expressed as % VO2max or percentage maximal heart rate were found, but Than expressed as VO2 in ml·kg–0.75·min–1 was significantly higher in the men compared to the women. The percentage utilization of f
emax and concentration of blood lactate at v
M was higher for the female runners. The women ran 2 days more each week than the men over the first 4 months during the half year preceding the marathon race. It was concluded that the higher VO2max and Than in the men was compensated for by more running, superior CR, and a higher exercise intensity during the race in the performance-matched female marathon runners. 相似文献
997.
What determines conformity to Bergmann's rule? 总被引:2,自引:0,他引:2
Aim Bergmann's rule, the tendency of body size within species in bird and mammal populations to be positively correlated with latitude, is among the best known biogeographical generalizations. The factors behind such clines, however, are not well understood. Here we use a large data base of 79 mammalian carnivore species to examine the factors affecting latitudinal size clines.
Location Worldwide.
Methods We measured the skulls and teeth of carnivores in natural history museums, and calculated the amount of variation in size explained by latitude, supplementing our measurements with published data. We examined the effects of a number of variables on the tendency to show latitudinal clines.
Results We found that geographical range and latitudinal extent are strongly related to size clines. Minimum temperatures across the range, net primary productivity and habitat diversity also have some, albeit much less, influence.
Main conclusions We suggest that species with large geographical ranges are likely to encounter significant heterogeneity in those factors that influence body size, and are thus likely to exhibit size clines. However, the key factors that determine body size may not always operate along a latitudinal (or other geographical) cline, but be spatially linked to patches in the species range. One such important factor is likely to be food availability, which we show is a strong predictor of size in the brown bear ( Ursus arctos ) but is not associated with a latitudinal cline. We argue that the spatial distribution of key resources within the species range constitutes a significant predictor of carnivore body size. 相似文献
Location Worldwide.
Methods We measured the skulls and teeth of carnivores in natural history museums, and calculated the amount of variation in size explained by latitude, supplementing our measurements with published data. We examined the effects of a number of variables on the tendency to show latitudinal clines.
Results We found that geographical range and latitudinal extent are strongly related to size clines. Minimum temperatures across the range, net primary productivity and habitat diversity also have some, albeit much less, influence.
Main conclusions We suggest that species with large geographical ranges are likely to encounter significant heterogeneity in those factors that influence body size, and are thus likely to exhibit size clines. However, the key factors that determine body size may not always operate along a latitudinal (or other geographical) cline, but be spatially linked to patches in the species range. One such important factor is likely to be food availability, which we show is a strong predictor of size in the brown bear ( Ursus arctos ) but is not associated with a latitudinal cline. We argue that the spatial distribution of key resources within the species range constitutes a significant predictor of carnivore body size. 相似文献
998.
Robert M. Cox Ryan Calsbeek 《Evolution; international journal of organic evolution》2010,64(3):798-809
Sexual size dimorphism (SSD) is thought to evolve due to sex differences in selection on body size, but it is largely unknown whether intraspecific variation in SSD reflects differences in sex‐specific selection among populations. We addressed this question by comparing viability selection between two island populations of the brown anole lizard (Anolis sagrei) that differ in the magnitude of male‐biased SSD. On both islands, females experienced stabilizing selection favoring intermediate size whereas males experienced directional selection favoring larger size. Thus, sex‐specific selection matched the overall pattern of male‐biased SSD, but population differences in the magnitude of SSD were not associated with local differences in selection. Rather, population differences in SSD appear to result from underlying differences in the environmental potential for a rapid growth, coupled with sex‐specific phenotypic plasticity. Males grew more slowly on the island with low SSD whereas growth of females did not differ between islands. Both sexes had substantially lower mass per unit length on the island with low SSD, suggesting that they were in a relatively poorer energetic condition. We propose that this energetic constraint disproportionately impacts growth of males due to their greater absolute energy requirements, thus driving intraspecific variation in SSD. 相似文献
999.
目的:探讨COPD患者改善体质量指数(BMD与肺功能变化的相关性.方法:经加强营养达正常BMI的患者(A组)与低BMI的COPD患者(B组),比较2组肺功能指标、6min步行距离、呼吸困难评分.结果:与B组相比,A组FEV1%、FEV1/FVC、SVC、MVV、IC均明显升高(P<0.01),RV/TLC明显上升(P<0.01),6min步行距离延长(P<0.01)、呼吸困难评分明显降低(P<0.01).Pearson 相关性分析显示,FEV1%、FEV1/FVC、SVC、MVV、IC、RV/TIC与BMI相关,6min步行距离与BMI呈正相关,呼吸困难评分与BMI呈负相关.结论:改善BMI可明显改善COPD患者的肺功能指标,减轻临床症状. 相似文献
1000.
MAYUMI YOSHIMURA 《Physiological Entomology》2013,38(3):226-232
Variations in δ13C and δ15N might arise from differences in nutrient allocation. Residence times of δ13C and δ15N vary among tissues depending on metabolic turnover rates. However, because of their small size, entire individual insects are generally used as single samples in isotope analyses. The present study aimed to determine the degree of isotope similarity among regions of the adult body and eggs in four species of Plecoptera (Amphinemura sp., Sweltsa sp., Kamimuria tibialis Pictet and Ostrovus sp.). Levels of δ13C and δ15N differ between the four species, being lowest in Amphinemura sp., and with δ15N being highest in Sweltsa sp. Egg masses contain consistently the lowest values of δ13C in the four species, with the δ15N value of eggs being highest in K. tibialis and Ostrovus sp., and lower in Amphinemura and Sweltsa spp. In Sweltsa sp., the δ15N levels of the dermal layers and cuticle are lowest, whereas the δ13C values of the dermal layers and cuticle are almost equal to those in other regions of the body, except egg masses. Oviposited individuals of Amphinemura and Sweltsa spp. have lower δ15N levels than individuals that have not oviposited. The rates of metabolism and incorporation of dietary metabolites will differ depending on the body regions and species. Differences in egg ecology such as egg developmental period and egg buoyancy among species are considered to impact on the values of δ13C and δ15N. These results will be useful for understanding the nutritional status of aquatic insects and their energy allocation. 相似文献