全文获取类型
收费全文 | 579篇 |
免费 | 26篇 |
国内免费 | 32篇 |
出版年
2024年 | 1篇 |
2023年 | 13篇 |
2022年 | 16篇 |
2021年 | 27篇 |
2020年 | 17篇 |
2019年 | 16篇 |
2018年 | 32篇 |
2017年 | 17篇 |
2016年 | 13篇 |
2015年 | 21篇 |
2014年 | 29篇 |
2013年 | 51篇 |
2012年 | 22篇 |
2011年 | 34篇 |
2010年 | 32篇 |
2009年 | 33篇 |
2008年 | 43篇 |
2007年 | 32篇 |
2006年 | 29篇 |
2005年 | 24篇 |
2004年 | 16篇 |
2003年 | 12篇 |
2002年 | 16篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 9篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 3篇 |
1995年 | 5篇 |
1994年 | 1篇 |
1993年 | 4篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1987年 | 2篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有637条查询结果,搜索用时 851 毫秒
81.
Teruo Kawada 《Bioscience, biotechnology, and biochemistry》2018,82(4):547-553
AbstractObesity is a key factor in metabolic syndrome. The study of metabolic syndrome focuses on the anti-weight gain properties of physiological mechanisms and food components. Abnormal energy metabolism is a major risk factor of metabolic syndrome. Chronic inflammation is a feature of obesity; cytokines from hypertrophied adipocytes cause inflammation in both adipose tissue and blood vessels, resulting in symptoms of metabolic syndrome. Tumor necrosis factor-α causes insulin resistance in adipocytes and regression of brown adipocytes, resulting in abnormal energy metabolism. Functional foods can serve as a strategy for prevention and treatment of obesity linked with metabolic processes in white and brown adipose tissues. Diet-induced thermogenesis caused by certain food components stimulates burning of stored fat within adipose tissues. A mechanistic understanding of dietary thermogenesis via the sympathetic nerve system will prove valuable for the development of precise strategies for the practical prevention of metabolic syndrome. 相似文献
82.
83.
Maryam Ahmadian Sihao Liu Shannon M. Reilly Nasun Hah Weiwei Fan Eiji Yoshihara Pooja Jha C. Daniel De Magalhaes Filho Sandra Jacinto Andrew V. Gomez Yang Dai Ruth T. Yu Christopher Liddle Annette R. Atkins Johan Auwerx Alan R. Saltiel Michael Downes Ronald M. Evans 《Cell reports》2018,22(11):2849-2859
84.
Kazuko Iwamoto Shuichi Kamo Yuichi Takada Ayana Ieda Takatoshi Yamashita Toshiro Sato Nobuhiro Zaima Tatsuya Moriyama 《Biochemistry and Biophysics Reports》2018
Soyasapogenol is a soyasaponin aglycone, which has been suggested to exert a more potent function than the glycoside form. In this study, the effect of soyasapogenol A and B on cultured adipocyte cell function was investigated using mouse 3T3-L1 adipocyte cells. 3T3-L1 cells were treated with insulin, dexamethasone, and 3-isobutyl-1-methylxanthine for differentiation to adipocytes, and the cells were then cultured in the presence of soyasapogenol A or B (6.25 or 12.5 µM). The media were harvested and refreshed every 2 d. After a 10 d culture, the cells were harvested and the triglyceride content of the cells was determined. The triglyceride content of soyasapogenol B-treated cells was significantly lower than those of vehicle-treated cells. Glycerol and free fatty acid levels in the soyasapogenol-treated cell media were higher than those in vehicle cells. However, there was no difference in the level of adipose triglyceride lipase among soyasapogenol A-, soyasapogenol B-, and vehicle-treated cells. The secreted adiponectin and resistin levels of soyasapogenol-treated cell media were also different compared with those of vehicle-treated cells. Especially, the secreted resistin level in soyasapogenol B-treated cell media was obviously reduced compared with that of vehicle-treated cells. Taken together, these results suggest that soyasapogenol B exerted an anti-obesity and anti-diabetic effect on adipocytes by lowering the cellular triglyceride level by accelerating triglyceride lipolysis with reduced resistin secretion. 相似文献
85.
Verena Hiebl Angela Ladurner Simone Latkolik Verena M. Dirsch 《Biotechnology advances》2018,36(6):1657-1698
Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting pool of potential ligands since they have been refined under evolutionary pressure to interact with proteins or other biological targets.This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed. 相似文献
86.
Fraser Heather Coles Scott M. Woodford Judith K. Frolov Audrey A. Murphy Eric J. Schroeder Friedhelm Bernlohr David A. Grund Vernon 《Molecular and cellular biochemistry》1997,167(1-2):51-60
The effect of diabetic status and insulin on adipocyte plasma membrane properties and fatty acid uptake was examined. Studies with inhibitors and isolated adipocyte ghost plasma membranes indicated 9Z, 11E, 13E, 15Z-octatetraenoic acid (cis-parinaric acid) uptake was protein mediated. Cis-parinaric acid uptake was inhibited by trypsin treatment or incubation with phloretin, and competed with stearic acid. The initial rate, but not maximal uptake, of cis-parinaric acid uptake was enhanced two-fold in adipocytes from diabetic rats. Concomitantly, the structure and lipid composition of adipocyte ghost membranes was dramatically altered. However, the increased initial rate of cis-parinaric acid uptake in the diabetic adipocytes was not explained by membrane alterations or by a two-fold decrease in cytosolic adipocyte fatty acid binding protein (ALBP), unless ALBP stimulated fatty acid efflux. Thus, diabetic status dramatically altered adipocyte fatty acid uptake, plasma membrane structu re, lipid composition, and cytosolic fatty acid binding protein. (Mol Cell Biochem 167: 51-60, 1997) 相似文献
87.
Haruhiko Maruyama Shinichi Noda Won-Young Choi Nobuo Ohta Yukifumi Nawa 《Parasitology international》1997,46(3):181-188
Fine binding specificities to Ascaris suum and A. lumbricoides antigens of the sera from patients with probable visceral larva migrans (VLM) due to A. suum infection were examined. Although multiple-dot enzyme-linked immunosorbent assay (ELISA) was found to be useful for the primary screening of patients, identification of the responsible species was sometimes difficult due to extensive cross reactions with other ascarid parasite antigens. Fine resolution to determine the causative pathogen was obtained by a rather classical Ouchterlony's double immunodiffusion test. The difference in the binding of the patients' sera to A. suum and A. lumbricoides antigens was also demonstrated by an inhibition ELISA. The patients' antibodies bound with higher avidity to the A. suum antigen than to the A. lumbricoides and Toxocara canis antigens. Combination of at least two different immunological assay methods is recommended for the diagnosis of VLM due to ascarid parasites. 相似文献
88.
89.
90.
Chrisna Durandt Fiona A. van Vollenstee Carla Dessels Karlien Kallmeyer Danielle de Villiers Candice Murdoch Marnie Potgieter Michael S. Pepper 《Journal of lipid research》2016,57(4):729-742
The ability of mesenchymal stromal cells (MSCs) to differentiate into adipocytes provides a cellular model of human origin to study adipogenesis in vitro. One of the major challenges in studying adipogenesis is the lack of tools to identify and monitor the differentiation of various subpopulations within the heterogeneous pool of MSCs. Cluster of differentiation (CD)36 plays an important role in the formation of intracellular lipid droplets, a key characteristic of adipocyte differentiation/maturation. The objective of this study was to develop a reproducible quantitative method to study adipocyte differentiation by comparing two lipophilic dyes [Nile Red (NR) and Bodipy 493/503] in combination with CD36 surface marker staining. We identified a subpopulation of adipose-derived stromal cells that express CD36 at intermediate/high levels and show that combining CD36 cell surface staining with neutral lipid-specific staining allows us to monitor differentiation of adipose-derived stromal cells that express CD36intermediate/high during adipocyte differentiation in vitro. The gradual increase of CD36intermediate/high/NRpositive cells during the 21 day adipogenesis induction period correlated with upregulation of adipogenesis-associated gene expression. 相似文献