Moulin Quignon : la redécouverte d’un site

The collection from Moulin Quignon is a coherent one, despite the diversity of its pieces, in the certainty of its origin, in its attachment to the researches led on the site in 1863–1864. Considered as a historic heritage, its study has nevertheless delivered significant scientific information, valid for the present, and, beyond that, to reintroduce the site of Moulin Quignon in the oldest Palaeolithic panel sites of the Somme valley.     

桉树新害虫——曲线纷夜蛾的生物学和生态特性研究

曲线纷夜蛾Polydesma boarmoides Guenée是我国桉树食叶害虫,已在部分桉树种植区造成严重危害。国内外仅在区域昆虫种类调查中发现并提及该虫,而未见其生物学特性、生态学特性和发生规律等方面的相关研究报道,因此,有必要对该虫进行更系统、深入的研究,为防控该虫提供依据。笔者2013年5月首次发现该虫在广东省紫金县危害桉树林,2016年5月再次发现该虫在茂名市危害桉树林。调查、研究结果表明:(1)曲线纷夜蛾起始取食灌木叶片直至叶片被取食殆尽后,逐步转移至桉树林继续取食桉树叶片;(2)曲线纷夜蛾在广东地区1年发生4代;(3)曲线纷夜蛾3-5龄幼虫在桉树林间呈现聚集分布,且聚集密度呈现随种群密度增大而增大的规律,而在桉树树冠上则呈均匀分布。     

Renaturation effects of cis and trans platinum II and IV compounds on calf thymus deoxyribonucleic acid.

The effects of cis dichlorodiammine platinum [cis Pt(II)], trans dichlorodiammine platinum (trans Pt(II)], cis tetrachlorodiammine platinum [cis Pt(IV)], trans tetrachlorodiammine platinum [trans Pt(IV)], and ethylenediaminedichloride platinum [Pt(II)en] on the absorption spectra, and thermal hyper- and hypochromicity of calf thymus DNA were investigated. Platinum-induced renaturation was studied as one parameter of interstrand cross-linking. Based on a DNA cross-linking hypothesis, the tumor-inhibitory platinum compounds cis Pt(II), cis Pt(IV) and Pt(II)en would be expected to induce renaturation following thermal denaturation, whereas the ineffective drugs, trans Pt(II) and trans Pt(IV) would not. All five bind to DNA in such a way as to induce renaturation. However, cis Pt(IV) requires at least a 3- to 4-fold longer incubation time than is required by the other compounds to form the coordination bonds necessary for renaturation. Maximum renaturation with all compounds was observed at a molar Pt/base ratio of 0.05 except cis Pt(IV), with which it was 0.25. The rate of the formation of the platinum-coordinated cross-links by fresh cis Pt(II) suggests two reactions or types of reactions occur. The first is rapid and destabilizes the DNA helix, whereas the second is slow and responsible for renaturation following thermal denaturation. These results suggest that cis Pt(IV) may be activated cellularly and that cross-linking is not the primary mechanism of action of the tumor-inhibitory platinum compounds.     

Gravettian tear-drop-shaped beads

The two regions southwestern Germany and southwestern France have yielded Gravettian personal ornaments in form of tear-drop-shaped beads. We present updated numbers of these artefacts, because during the recent excavations since 2002 in Hohle Fels cave near the city of Ulm, Southwest Germany, additional beads were found. The present paper proposes for the first time a typo-technological study of the tear-drop-shaped beads.     

¿Qué pacientes se benefician más de la atención geriátrica hospitalaria en opinión de los especialistas en Geriatría?

Objective

To assess the most appropriate criteria considered by geriatricians to select patients who might benefit the most from geriatric hospital care.

Material and methods

We carried out a survey that consisted of various socio-demographic, clinical, functional and mental criteria included in the definition of the geriatric and frail elderly patient. The survey was sent to all specialists in geriatrics in the different hospitals of the Madrid Health Service. They were asked to answer to each criterion indicating whether they considered it as high priority, priority, low priority or no priority. The responses were clustered by type of hospital: acute hospitals with or without a post-graduate geriatric program for medical residents, and medium and long stay hospitals.

Results

A total of 83 questionnaires were completed (70% of the study population): 42 teaching hospitals a post-graduate geriatric program (74% of possible), 20 of those with an emergency department but without a post-graduate geriatric program (56% of possible), and 21 medium and long stay hospitals (84% of potential). All proposed criteria were considered individually as priority or high-priority by more than 50% of respondents. An age 85 years and over, admission for hip fracture, the presence of severe cognitive or functional impairment, frailty, and unexplained deterioration of health status, were considered individually as criteria for selecting high-priority target population by more than 85% of respondents.

Conclusions

Certain criteria, such as advanced age, or the presence of geriatrics-specific conditions, such as hip fracture or severe functional or cognitive impairment, are identified by geriatricians as useful to select patients to receive geriatric specialist hospital care.     

艾叶多糖提取率影响因素分析及提取条件优化

艾叶是菊科(Compositae)植物艾(Artemisia argyi Lévl.et Vant.)的干燥叶,为常用中药材之一,药用历史悠久,具有苦燥辛散、理气血、温经脉、逐寒湿、止冷痛等功效,为重要的妇科用药,可用于治疗脘腹冷痛、经寒不调、宫冷不孕等证.此外,利用艾叶预防瘟疫已有悠久的历史.现代药理研究表明:艾叶是一种广谱抗菌抗病毒中药,对多种病毒和细菌有抑制和杀伤作用,对呼吸系统疾病以及心血管等慢性疾病有一定的防治作用[1-3].因此,将艾叶中的有效成分分别提取和纯化并加以分析以及功能检测,具有深远意义.     

Synthesis and investigation of spectral and electrochemical properties of alkyl-substituted planar binuclear phthalocyanine complexes sharing a common naphthalene ring

Hexa-tert-butyl and dodeca-n-butyl-substituted planar binuclear phthalocyanines sharing a common naphthalene ring with Mg as a central metal were synthesized with high yields and characterized by UV/Vis spectra, luminescence spectra, NMR, electrochemical, and spectroelectrochemical measurements. On the base of these complexes, the metal-free phthalocyanine ligands and the series of binuclear phthalocyanine complexes of rare earth elements (REE) were synthesized.All compounds obtained revealed an intensive near IR-absorption reaching 855 nm for trinuclear phthalocyanine. A crucial increase in NMR spectra resolution was achieved by the addition of ethylene glycol as a disaggregating agent. Spectroelectrochemical measurements during oxidation showed reversible changes of absorbance at 709 and 800 nm.     

3 Beta-hydroxyolean-12-en-27-oic acid: a cytotoxic, apoptosis-inducing natural drug against COLO-205 cancer cells

3Beta-hydroxyolean-12-en-27-oic acid (1), a biologically active, pentacyclic triterpenoid isolated from the rhizomes of Astilbe chinensis, was found to be considerably more cytotoxic toward human colorectal carcinoma (COLO-205) and human cervical squamous carcinoma (HeLa) cells than its congener oleanolic acid (4). This suggests that the position of the COOH group significantly affects the cytotoxicity of oleanane-type pentacyclic triterpene carboxylic acids. To elucidate the underlying biological mechanism responsible for the cytotoxicity of 1, we investigated its growth-inhibitory effect on COLO-205 cells. Compound 1 induced a marked concentration- and time-dependent inhibition of cell proliferation, with the typical morphological characteristics of apoptosis, and under formation of DNA ladders in agarose-gel electrophoresis. Flow-cytometric analysis showed that the cell cycle of COLO-205 cells exposed to 1 was arrested in the G0/G1 phase. Also, 1 increased and decreased the expression of Bax and Bcl-2 proteins, respectively, and lowered the mitochondrial transmembrane potential (delta psi(m)). The peptidic caspase-3 inhibitor NH2-Asp-Glu-Val-Asp-CHO (at 1 microM) could increase the viability of COLO-205 cells previously treated with 1. These results indicate that 1 induces efficient cell apoptosis through down-regulating Bcl-2 expression, up-regulating Bax expression, lowering delta psi(m), and by activating the caspase-3 pathway.     

Le bioclimat Mediterraneen: Analyse des formes climatiques par le systeme d'Emberger

Plant Ecology - In this second report on the Mediterranean bioclimate, the author treats the method developed by Emberger (1930 to 1971) to analyse the Mediterranean climate as defined in the...