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排序方式: 共有148条查询结果,搜索用时 15 毫秒
91.
Stella C. Junqueira Eduarda G.Z. Centeno Kevin A. Wilkinson Helena Cimarosti 《生物化学与生物物理学报:疾病的分子基础》2019,1865(8):2001-2007
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the nigrostriatal pathway. The etiology of PD remains unclear and most cases are sporadic, however genetic mutations in more than 20 proteins have been shown to cause inherited forms of PD. Many of these proteins are linked to mitochondrial function, defects in which are a central characteristic of PD. Post-translational modifications (PTMs) allow rapid and reversible control over protein function. Largely focussing on mitochondrial dysfunction in PD, here we review findings on the PTMs phosphorylation, SUMOylation and ubiquitination that have been shown to affect PD-related proteins. 相似文献
92.
Many recent developments in European marine and estuarine science have been against the demands of European Union legislation. The implementation of certain statutes, the role of scientists and the nature of the data required are discussed using examples from the UK, the Netherlands and Portugal. This includes the implementation of the EU Directives on Urban Waste-water Treatment, the control of Nitrates, the designation of Species and Habitats, the control of Dangerous Substances, the statutory requirement for Environmental Impact Assessments and the recently proposed Water Framework Directive. For these, the integration of physical, chemical and biological monitoring and investigation is discussed in relation to the science dictated by the legislative and administrative requirements. Each of these Directives requires the development of generic guidelines and protocols for implementation and the use of national enabling legislation. This indicates that, in several cases, the science should concentrate on monitoring and assessment in a well-structured and quality-controlled manner. The paper concludes by summarising developments based on similarities in the implementation of present and proposed Directives across Europe. 相似文献
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There are six main species of shellfish of commercial importance within the UK (mussels, flat oysters, cockles, king scallops, Manila clams and lobsters) which can be thought of as ranched to varying degrees. A seventh (Pacific oysters) can be included, since a very small proportion of the production may undergo a period of growth on natural habitats in some areas. An eighth species (Palourdes or native clams) appeared in the statistics for the first time in a number of years in 1998. Seafish, as part of its role in promoting the sustainable management of resources, has examined the current state of the shellfish aquaculture industry in the UK. 相似文献
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The sequence domains that contribute to the surfaces of contact between Troponin-C and the other regulatory protein subunits of skeletal muscle troponin are proposed on the basis of data obtained by proton magnetic resonance and other physicochemical studies on the interaction with Troponin-I of both Troponin-C and its peptide fragments. Marked sequence homology in Troponin-C from various species is found for the residues involved in subunit linkage. The role of the recognition sites is discussed. 相似文献
100.
Jennifer A. Lambrecht Beth Ann Browne Diana M. Downs 《The Journal of biological chemistry》2010,285(45):34401-34407
The YjgF/YER057c/UK114 family of proteins is highly conserved across all three domains of life and currently lacks a consensus biochemical function. Analysis of Salmonella enterica strains lacking yjgF has led to a working model in which YjgF functions to remove potentially toxic secondary products of cellular enzymes. Strains lacking yjgF synthesize the thiamine precursor phosphoribosylamine (PRA) by a TrpD-dependent mechanism that is not present in wild-type strains. Here, PRA synthesis was reconstituted in vitro with anthranilate phosphoribosyltransferase (TrpD), threonine dehydratase (IlvA), threonine, and phosphoribosyl pyrophosphate. TrpD-dependent PRA formation in vitro was inhibited by S. enterica YjgF and the human homolog UK114. Thus, the work herein describes the first biochemical assay for diverse members of the highly conserved YjgF/YER057c/UK114 family of proteins and provides a means to dissect the cellular functions of these proteins. 相似文献