全文获取类型
收费全文 | 250篇 |
免费 | 1篇 |
国内免费 | 1篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 4篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 10篇 |
2014年 | 21篇 |
2013年 | 25篇 |
2012年 | 10篇 |
2011年 | 26篇 |
2010年 | 23篇 |
2009年 | 11篇 |
2008年 | 9篇 |
2007年 | 17篇 |
2006年 | 7篇 |
2005年 | 8篇 |
2004年 | 7篇 |
2003年 | 9篇 |
2002年 | 7篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 7篇 |
1978年 | 1篇 |
排序方式: 共有252条查询结果,搜索用时 0 毫秒
251.
The nature of gamma-aminobutyric acid (GABA) transport has been investigated in preparations of rat brain synaptosomes using a number of thiol reagents with varying membrane permeabilities. N-Ethylmaleimide, p-chloromercuribenzoate and p-chloromercuriphenylsulfonate effectively inhibited GABA transport in both directions (i.e., uptake and release) whereas 5,5'-dithiobis-2-nitrobenzoate, mercaptopropionate and N- nitroethylenediamine were much less effective, or ineffective, even at millimolar concentrations. For each of the thiol reagents, the inhibition profile for GABA uptake was approximately the same as that for its release. The effectiveness of the reagents indicates that there is an external, reactable SH-group on the transporter, that the thiol reagent must be somewhat lipophilic for it to react with the SH-group(s), and that the same synaptosomal transport system is responsible for both uptake and release of GABA. 相似文献
252.
Peter Moldéus Peter J. OBrien Hj?rdis Thor Margareta Berggren Sten Orrenius 《FEBS letters》1983,154(2):411-415
Horseradish peroxidase-catalyzed N-demethylation of aminopyrine and dimethylaniline results in generation of free radical intermediates which can interact with glutathione (GSH) to form a glutathione radical. This can either dimerize to yield glutathione disulfide or react with O2 to form oxygenated products of glutathione. Ethylmorphine is not a substrate in the peroxidase-mediated reaction, and free radical intermediates which react with GSH, are not formed from aminopyrine and dimethylaniline when the horseradish peroxidase/H2O2 system is replaced by liver microsomes and NADPH. Therefore, it appears unlikely that formation of free radical intermediates can be responsible for the depletion of GSH observed during N-demethylation of several drugs in isolated liver cells. 相似文献