全文获取类型
收费全文 | 2747篇 |
免费 | 217篇 |
国内免费 | 276篇 |
出版年
2023年 | 36篇 |
2022年 | 49篇 |
2021年 | 52篇 |
2020年 | 53篇 |
2019年 | 68篇 |
2018年 | 59篇 |
2017年 | 86篇 |
2016年 | 120篇 |
2015年 | 82篇 |
2014年 | 108篇 |
2013年 | 132篇 |
2012年 | 90篇 |
2011年 | 117篇 |
2010年 | 110篇 |
2009年 | 234篇 |
2008年 | 225篇 |
2007年 | 217篇 |
2006年 | 219篇 |
2005年 | 168篇 |
2004年 | 145篇 |
2003年 | 125篇 |
2002年 | 87篇 |
2001年 | 71篇 |
2000年 | 70篇 |
1999年 | 54篇 |
1998年 | 52篇 |
1997年 | 48篇 |
1996年 | 38篇 |
1995年 | 43篇 |
1994年 | 35篇 |
1993年 | 35篇 |
1992年 | 18篇 |
1991年 | 28篇 |
1990年 | 22篇 |
1989年 | 26篇 |
1988年 | 15篇 |
1987年 | 13篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 7篇 |
1980年 | 8篇 |
1979年 | 7篇 |
1978年 | 9篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1973年 | 3篇 |
1952年 | 2篇 |
排序方式: 共有3240条查询结果,搜索用时 734 毫秒
81.
Jose Simon Jen Yu Wei Mirjana Randić P. R. Burgess 《Somatosensory & motor research》2013,30(2):127-147
Plots were made of multiunit activity versus ankle joint position for receptors in each of the 12 muscles crossing the cat ankle joint, except peroneus tertius, by recording from populations of afferent fibers in muscle nerves. The discharge was measured 15 or 30 sec after terminating the movements that altered the position of the joint. These recordings were dominated by large-spike activity that would be expected to originate mainly from primary spindle endings. Seven of the 12 muscles also cross other joints. Their responses at a given ankle joint position were so altered by changes in the position of the knee or toe joints that they could not reliably signal the position of the ankle joint. As judged from multiunit recording, receptors in each of the five muscles specific to the ankle joint were influenced by more than one axis of ankle joint displacement.Single-unit recording from dorsal root filaments was used to determine whether primary or secondary spindle receptors in soleus and tibialis anterior could selectively signal one axis of ankle joint rotation. Individual soleus receptors were tested both on the flexion extension axis and with a combined adduction–eversion movement.For 38 of the 70 soleus receptors examined (54%), firm adduction–eversion produced a level of activity greater than that caused by 10° of flexion, and for 77% the level of activity was greater than that caused by 5° of flexion. For 168 of the 184 tibialis anterior receptors studied (91%), firm abduction inversion produced a level of activity greater than that caused by 10° of extension. Thus few receptors were found that responded exclusively to one axis of rotation.One way in which the position of the ankle joint could be specified in the face of multiaxial receptor activity is by examining the receptor discharge from more than one muscle. A suggestion for how the nervous system might do this is given in the discussion. 相似文献
82.
Ronald T. Verrillo Stanley J. Bolanowski Francis P. McGlone 《Somatosensory & motor research》2013,30(4):352-360
The subjective experience of tactile roughness was judged by subjects using the method of absolute magnitude estimation (AME). The stimuli were 11 grades of sandpaper having particle diameters ranging from 16 to 905 mum. All of the estimates resulted in power functions when assigned numbers were plotted as a function of particle diameter. It was determined that on the finger pad of the index finger and the thumb there was no difference between the active and passive modes of stimulation and that there was no difference in roughness estimates made on the finger and on the thumb. When the finger and thumb were stimulated simultaneously, higher numbers were assigned for a given stimulus indicating the presence of a form of spatial summation at these sites. The pleasantness of the tactile sensation, as assessed using AME, was inversely related to the roughness estimates. Furthermore, hydration of the stratum corneum with water and three concentrations of surfactant solutions reduced the sensation of roughness below that of normally hydrated skin. 相似文献
83.
Sayali C. Ranade Sarfaraz Nawaz Arnab Chakrabarti Pierre Gressens Shyamala Mani 《Hormones and behavior》2013
"The goal of this study was to examine the effect of maternal iron deficiency on the developing hippocampus in order to define a developmental window for this effect, and to see whether iron deficiency causes changes in glucocorticoid levels. The study was carried out using pre-natal, post-natal, and pre + post-natal iron deficiency paradigm. Iron deficient pregnant dams and their pups displayed elevated corticosterone which, in turn, differentially affected glucocorticoid receptor (GR) expression in the CA1 and the dentate gyrus. Brain Derived Neurotrophic Factor (BDNF) was reduced in the hippocampi of pups following elevated corticosterone levels. Reduced neurogenesis at P7 was seen in pups born to iron deficient mothers, and these pups had reduced numbers of hippocampal pyramidal and granule cells as adults. Hippocampal subdivision volumes also were altered. The structural and molecular defects in the pups were correlated with radial arm maze performance; reference memory function was especially affected. Pups from dams that were iron deficient throughout pregnancy and lactation displayed the complete spectrum of defects, while pups from dams that were iron deficient only during pregnancy or during lactation displayed subsets of defects. These findings show that maternal iron deficiency is associated with altered levels of corticosterone and GR expression, and with spatial memory deficits in their pups." 相似文献
84.
Igor F. Tsigelny Valentina L. Kouznetsova Nilima Biswas Sushil K. Mahata Daniel T. O’Connor 《Bioorganic & medicinal chemistry》2013,21(18):5855-5869
The endogenous catecholamine release-inhibitory peptide catestatin (CST) regulates events leading to hypertension and cardiovascular disease. Earlier we studied the structure of CST by NMR, molecular modeling, and amino acid scanning mutagenesis. That structure has now been exploited for elucidation of interface pharmacophores that mediate binding of CST to its target, with consequent secretory inhibition. Designed pharmacophore models allowed screening of 3D structural domains. Selected compounds were tested on both cultured catecholaminergic cells and an in vivo model of hypertension; in each case, the candidates showed substantial mimicry of native CST actions, with preserved or enhanced potency and specificity. The approach and compounds have thus enabled rational design of novel drug candidates for treatment of hypertension or autonomic dysfunction. 相似文献
85.
Ester Formation by Alcohol Acetyltransferase from Brewers’ Yeast 总被引:2,自引:0,他引:2
Alcohol acetyltransferase responsible for the formation of acetate esters during beer fermentation was found to be localized at the cell membrane of brewers’ yeast. This cell membrane-bound enzyme was purified 120-fold by solubilization with Triton X-100, gel filtration on a Sepharose 6B column and chromatography on a DEAE-Sephadex A-50 column. The enzyme was most active at 30°C at pH 7 ? 8. It was least active against C3 alcohol among C1 ? C6 alcohols, and slightly more active against straight-chain alcohols than against branched-chain alcohols with the same carbon number. The enzyme was strongly inhibited by unsaturated fatty acids, heavy metal ions and sulfhydryl reagents. 相似文献
86.
南方红壤区3年生茶园土壤呼吸特征 总被引:4,自引:0,他引:4
为探讨南方红壤区茶园的土壤呼吸特征,采用LI-Cor8100开路式土壤碳通量测定系统观测3年生茶园系统的土壤呼吸速率,对茶园土壤呼吸速率的季节变化和在茶行尺度上的空间异质性进行了研究。结果表明,茶园土壤呼吸速率的月动态变化呈明显的单峰曲线特征,峰值出现在8月;茶园土壤呼吸速率的月动态变化与温度呈极显著相关(P<0.01),土壤10 cm的温度能够解释茶园不同观测区域土壤呼吸速率月动态变化的67.79%~88.52%;用指数方程计算的茶园不同观测区域土壤呼吸Q10值为1.58~1.86。在茶行尺度上,茶园土壤呼吸速率存在明显的空间异质性,土壤呼吸速率通常在距离茶树基部较近的位置较高;根系生物量能够解释茶园土壤呼吸速率在茶行尺度上空间变异的82.68%。因此,根系分布的空间差异是造成茶园土壤呼吸速率空间异质性的主要原因。 相似文献
87.
Charlotte Ndiribe Loïc Pellissier Silvia Antonelli Anne Dubuis Julien Pottier Pascal Vittoz Nicolas Salamin 《Ecology and evolution》2013,3(15):4925-4939
The trend of closely related taxa to retain similar environmental preferences mediated by inherited traits suggests that several patterns observed at the community scale originate from longer evolutionary processes. While the effects of phylogenetic relatedness have been previously studied within a single genus or family, lineage‐specific effects on the ecological processes governing community assembly have rarely been studied for entire communities or flora. Here, we measured how community phylogenetic structure varies across a wide elevation gradient for plant lineages represented by 35 families, using a co‐occurrence index and net relatedness index (NRI). We propose a framework that analyses each lineage separately and reveals the trend of ecological assembly at tree nodes. We found prevailing phylogenetic clustering for more ancient nodes and overdispersion in more recent tree nodes. Closely related species may thus rapidly evolve new environmental tolerances to radiate into distinct communities, while older lineages likely retain inherent environmental tolerances to occupy communities in similar environments, either through efficient dispersal mechanisms or the exclusion of older lineages with more divergent environmental tolerances. Our study illustrates the importance of disentangling the patterns of community assembly among lineages to better interpret the ecological role of traits. It also sheds light on studies reporting absence of phylogenetic signal, and opens new perspectives on the analysis of niche and trait conservatism across lineages. 相似文献
88.
利用表型数据构建陆地棉核心种质 总被引:3,自引:0,他引:3
以5963份陆地棉种质资源为材料,根据品种主要突变性状和品种类型分组成11组群,在分组的基础上利用21个表型性状,用非加权类平均聚类分析法,构建了281份陆地棉核心种质,占全部种质资源总量的4.71%。利用不同性状的均值t测验、方差F测验、变异系数、多样性指数t检验、均值、极差、表型方差、变异系数、均值差异百分率、方差差异百分率、极差符合率、变异系数变化率、主成分分析等参数进行核心种质代表性检验和评价。结果表明,所构建的陆地棉核心种质可以代表全部种质的遗传多样性。 相似文献
89.
《Fungal Ecology》2016
Co-occurring orchid species tend to occupy different areas and associate with different mycorrhizal fungi, suggesting that orchid mycorrhizal (OrM) fungi may be unevenly distributed within the soil and, therefore, impact the aboveground spatial distribution of orchids. To test this hypothesis, we investigated spatial variations in the community of potential OrM associates within the roots of three co-habitating orchid species (Anacamptis morio, Gymnadenia conopsea, and Orchis mascula) and the surrounding soil in an orchid-rich calcareous grassland in Southern Belgium using 454 amplicon pyrosequencing. Putative OrM fungi were broadly distributed in the soil, although variations in community composition were strongly related to the proximal host plant. The diversity and frequency of sequences corresponding to OrM fungi in the soil declined with increasing distance from orchid plants, suggesting that the clustered distribution of orchid species may to some extent be explained by the localised distribution of species-specific mycorrhizal associates. 相似文献
90.