排序方式: 共有35条查询结果,搜索用时 109 毫秒
11.
Alicja Kluczyk Julita Ludwiczak Maciej Modzel Mariola Kuczer Marek Cebrat Monika Biernat Remigiusz Bąchor 《化学与生物多样性》2021,18(3):e2000992
Argireline-containing cosmetics attract public interest due to their confirmed reduction of facial wrinkles. Argireline is a peptide that works by inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox-like effect. Therefore, it is used as a safe needle-free alternative to botox treatment. In this work we investigated the presence of Argireline in cosmetic creams and sera by application of reversed phase liquid chromatography and tandem mass spectrometry (RP-HPLC/MS and MS/MS). The analysis revealed the presence of argireline and its oxidized form in several different cosmetics. The methionine residue in Argireline sequence was indicated as oxidation point according to neutral loss MS studies. The developed sample preparation strategy minimizes and monitors methionine oxidation, bringing to our attention the question of impact of ingredients on the stability of cosmetic product. 相似文献
12.
P Tucci G Porta M Agostini D Dinsdale I Iavicoli K Cain A Finazzi-Agró G Melino A Willis 《Cell death & disease》2013,4(3):e549
The long-term health risks of nanoparticles remain poorly understood, which is a serious concern given their prevalence in the environment from increased industrial and domestic use. The extent to which such compounds contribute to cellular toxicity is unclear, and although it is known that induction of oxidative stress pathways is associated with this process, the proteins and the metabolic pathways involved with nanoparticle-mediated oxidative stress and toxicity are largely unknown. To investigate this problem further, the effect of TiO2 on the HaCaT human keratinocyte cell line was examined. The data show that although TiO2 does not affect cell cycle phase distribution, nor cell death, these nanoparticles have a considerable and rapid effect on mitochondrial function. Metabolic analysis was performed to identify 268 metabolites of the specific pathways involved and 85 biochemical metabolites were found to be significantly altered, many of which are known to be associated with the cellular stress response. Importantly, the uptake of nanoparticles into the cultured cells was restricted to phagosomes, TiO2 nanoparticles did not enter into the nucleus or any other cytoplasmic organelle. No other morphological changes were detected after 24-h exposure consistent with a specific role of mitochondria in this response. 相似文献
13.
本文从快速检测的必要性出发,介绍了ATP生物荧光法及其原理,并针对某款化妆品通过一系列实验建立了一种快速检测菌落总数的方法。将该方法用于CTFA(美国化妆品香料香精协会,Cosmetic Toiletry and Fragrance Association)实验中,并通过与平板计数法结果进行比对,发现该方法可以有效的运用于样品细菌总数的快速检测。 相似文献
14.
Akira Hisanaga Yukuo Eguchi Miyuki Hirata Noburu Ishinishi 《Biological trace element research》1988,16(1):77-85
During the past few centuries, lead production, consumption and emissions, to our total environment have increased remarkably.
We have determined the concentrations of lead in 41 well-preserved ancient and 11 contemporary rib bones of a mature age (40–60
y), with a view to historically evaluating lead exposure in humans. The oldest Japanese bones (1000–300b.c.) were found to contain a mean of 0.58 μg Pb/g dry wt and a mean molar ratio of lead to calcium of 0.6×10−6, compared with 4.7–5.2×10−6 in the bones of the Edo era (1600–1867a.d.) and contemporary residents in Japan. The mean molar ratios of female bones were always higher than those of male bones for
each era. From this fact we may assume that facial cosmetics were one of the main routes of lead exposure among the ancient
Japanese, especially those who lived during the Edo era. 相似文献
15.
Yamada MO Okayama M Chikamori K Yamada G Moriwake Y Minami T Tohno S Takeuchi R Tohno Y 《Biological trace element research》2000,77(2):149-158
Marker elements were estimated from the red cosmetics collected from different ancient burials and mine ruins in three separate
districts of Japan. Element levels were displayed in reference to the relative amount to sulfur (RA/S), by which the cosmetics
were divided into five types: I—a low Hg/S with a low Fe/S; II—both moderate Hg/S and Fe/S; III—a moderate Hg/S with a high
Fe/S; III 2—a high Hg/S with a moderate Fe/S; IV—a high Hg/S with a high Fe/S. The cosmetics can be further characterized
by referring to other contaminants such as Zn, Cu, and Mn. These combined analyses with contaminant metals were capable of
characterizing the origins of the cosmetics; it is useful to compare them to each other. The cosmetics were identified as
being due to several groups of contaminants from ancient mines in Japan, and also with this system analysis of the markers
it is possible to identify them from neighboring countries. 相似文献
16.
17.
18.
利用多重PCR技术建立快速检测化妆品中三种致病菌的方法。根据已报道的大肠杆菌phoA基因、铜绿假单胞菌外膜蛋白基因oprL和金黄色葡萄球菌特异性序列SmaI选择特异性引物,对人工染菌化妆品进行多重PCR检测。结果显示,三种致病菌的基因组DNA均可与各自引物特异性结合,扩增产物大小分别为622 bp、504 bp和426 bp。该方法用于人工污染的化妆品中,大肠杆菌的检出限浓度为103 CFU/mL,铜绿假单胞菌和金黄色葡萄球菌的检出限浓度为105 CFU/mL。作者建立的多重PCR方法可同时快速、特异地对化妆品中三种致病菌进行检测,在化妆品行业具有较大的应用价值。 相似文献
19.
Campana R Scesa C Patrone V Vittoria E Baffone W 《Letters in applied microbiology》2006,43(3):301-306
AIM: To evaluate the microbial contamination of 91 cosmetics (23 o/w emulsions, 47 tensiolytes, 21 aqueous pastes) in three different states of use (intact, in-use, ending product) and the protection efficacy of the preservative systems most frequently used in the analysed cosmetic formulations. METHODS AND RESULTS: Total bacterial count, isolation and identification of pathogenic isolates were performed on the collected cosmetics. About 10.6% of tensiolytes (13.5% bath foam, 6.7% shampoo, 10% liquid soaps) were contaminated by Staphylococcus warneri, Staphylococcus epidermidis and Pseudomonas putida. The efficacy of the preservative systems of two cosmetic products, tested against standard micro-organisms (Staphylococcus aureus ATCC 4338 and Pseudomonas aeruginosa ATCC 9027) and two isolates from cosmetics in this study (S. epidermidis and P. putida), satisfied the Cosmetics, Toiletries, and Fragrance Association and Official Italian Pharmacopeia criteria, while only one tested cosmetic respected the Rapid Challenge Test criterion. CONCLUSIONS: Contaminated cosmetic products are relatively uncommon, but some products, unable to suppress the growth of several micro-organisms, represent a potential health hazard. SIGNIFICANCE AND IMPACT OF THE STUDY: The challenge test may be performed not only during the preparation of the preservative system in the intact cosmetics, but also be used to evaluate the protection efficacy during their use. 相似文献
20.
Naoko Yamazaki Satoshi Yamakawa Takumi Sugimoto Yuta Yoshizaki Ryoma Teranishi Takaaki Hayashi 《Journal of liposome research》2013,23(4):275-284
AbstractTransdermal drug delivery systems are a key technology for skin-related diseases and for cosmetics development. The delivery of active ingredients to an appropriate site or target cells can greatly improve the efficacy of medical and cosmetic agents. For this study, liposome-based transdermal delivery systems were developed using pH-responsive phytosterol derivatives as liposome components. Succinylated phytosterol (Suc-PS) and 2-carboxy-cyclohexane-1-carboxylated phytosterol (CHex-PS) were synthesized by esterification of hydroxy groups of phytosterol. Modification of phytosterol derivatives on 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes was confirmed by negatively zeta potentials at alkaline pH and the change of zeta potentials with decreasing pH. In response to acidic pH and temperatures higher than body temperature, Suc-PS-containing and CHex-PS-containing liposomes exhibited content release at intracellular acidic compartments of the melanocytes at the basement membrane of the skin. Phytosterol-derivative-containing liposomes were taken up by murine melanoma-derived B16-F10 cells. These liposomes delivered their contents into endosomes and cytosol of B16-F10 cells. Furthermore, phytosterol-derivative-containing liposomes penetrated the 3?D skin models and reached the basement membrane. Results show that pH-responsive phytosterol-derivative-containing DMPC liposomes are promising for use in transdermal medical or cosmetic agent delivery to melanocytes. 相似文献