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961.
The pattern of the evolutionary radiation of modern birds (Neornithes) has been debated for more than 10 years. However, the early fossil record of birds from the Paleogene, in particular, the Lower Eocene, has only recently begun to be used in a phylogenetic context to address the dynamics of this major vertebrate radiation. The Cretaceous-Paleogene (K-P) extinction event dominates our understanding of early modern bird evolution, but climate change throughout the Eocene is known to have also played a major role. The Paleocene and Lower Eocene was a time of avian diversification as a result of favourable global climatic conditions. Deteriorations in climate beginning in the Middle Eocene appear to be responsible for the demise of previously widespread avian lineages like Lithornithiformes and Gastornithidae. Other groups, such as Galliformes display replacement of some lineages by others, probably related to adaptations to a drier climate. Finally, the combination of slowly deteriorating climatic conditions from the Middle Eocene onwards, appears to have slowed the evolutionary rate in Europe, as avian faunas did not differentiate markedly until the Oligocene. Taking biotic factors in tandem with the known Paleogene fossil record of Neornithes has recently begun to illuminate this evolutionary event. Well-preserved fossil taxa are required in combination with ever-improving phylogenetic hypotheses for the inter-relationships of modern birds founded on morphological characters. One key avifauna of this age, synthesised for the first time herein, is the Lower Eocene Fur Formation of Denmark. The Fur birds represent some of the best preserved (often in three dimensions and with soft tissues) known fossil records for major clades of modern birds. Clear phylogenetic assessment of these fossils will prove critical for future calibration of the neornithine evolutionary timescale. Some early diverging clades were clearly present in the Paleocene as evidenced directly by new fossil material alongside the phylogenetically constrained Lower Eocene taxa. A later Oligocene radiation of clades other than Passeriformes is not supported by available fossil data. 相似文献
962.
963.
Iconomidou VA Chryssikos GD Gionis V Galanis AS Cordopatis P Hoenger A Hamodrakas SJ 《Journal of structural biology》2006,156(3):480-488
Peptide-analogues of the A and B families of silkmoth chorion proteins form amyloid fibrils under a variety of conditions [Iconomidou, V.A., Vriend, G. Hamodrakas, S.J. 2000. Amyloids protect the silkmoth oocyte and embryo. FEBS Lett. 479, 141-145; Iconomidou,V.A., Chryssikos, G.D.,Gionis, V., Vriend, G., Hoenger, A., Hamodrakas, S.J., 2001. Amyloid-like fibrils from an 18-residue peptide-analogue of a part of the central domain of the B-family of silkmoth chorion protein. FEBS Lett. 499, 268-273; Hamodrakas, S.J. Hoenger, A., Iconomidou, V. A., 2004 . Amyloid fibrillogenesis of silkmoth chorion protein peptide-analogues via a liquid crystalline intermediate phase. J. Struct. Biol. 145, 226-235.], which led us to propose that silkmoth chorion is a natural protective amyloid. In this study, we designed and synthesized two mutant peptide-analogues of the central conservative domain of the A family: (a) one, cA_m1, with a length half of that of the central domain of the A family, which folds and self-assembles, in various conditions, into amyloid fibrils very similar in properties and structure to the fibrils formed by the cA peptide, which corresponds to the entire length of the A family central domain [Iconomidou, V.A., Vriend, G. Hamodrakas, S.J. 2000. Amyloids protect the silkmoth oocyte and embryo. FEBS Lett. 479, 141-145.], in full support of our previous proposal, (b) the second, cA_m2, differing from cA_m1 at three positions, where three glutamates have replaced two valines and one alanine residues, does not form amyloid fibrils in any conditions. It appears that (a) the amyloidogenic properties of silkmoth chorion peptides are encoded into the tandemly repeating hexapeptides comprising the central domain of silkmoth chorion proteins, and, that (b) suitable mutations, properly and carefully designed, greatly affect the strong amyloidogenic properties inherent in certain aminoacid sequences and may inhibit amyloid formation. 相似文献
964.
by MICHAEL J. VENDRASCO SUSANNAH M. PORTER† ARTEM KOUCHINSKY‡ GUOXIANG LI§ CHRISTINE Z. FERNANDEZ¶ 《Palaeontology》2010,53(1):97-135
Abstract: Numerous new cases of preserved shell microstructure were discovered in molluscs from the Middle Cambrian Gowers Formation (Ptychagnostus atavus/Peronopsis opimus Zone, Floran Stage) in the Georgina Basin, Australia. The new data provide further evidence that, by the Middle Cambrian, molluscan shell microstructures were diverse, and many molluscs had a complex shell with multiple types of shell microstructure. In addition, many new occurrences of laminar microstructures are described herein. For many, the nature of these laminar microstructures is not known, but in three species the microstructure is foliated calcite, and in at least two the microstructure is more likely to have been calcitic semi‐nacre, a type of microstructure known in brachiopods and bryozoans but unknown in modern molluscs. This commonality among these three closely related lophotrochozoans underscores a similar mechanism of biomineralization. Moreover, these observations suggest a prevalence of calcite‐shelled lineages among molluscs from the Middle Cambrian, a time of calcite seas. In addition, the broad occurrence of laminar, nacre‐like microstructures in many of these fossils reveals how widespread these strong (fracture‐resistant) microstructures were in Middle Cambrian molluscs. Additionally, a few specimens of Yochelcionella preserve imprints of a bilaterally symmetrical pair of muscle scars. New taxa described here include Corystos thorntoniensis gen. et sp. nov., Yochelcionella snorkorum sp. nov., Yochelcionella saginata sp. nov., and Anhuiconus? agrenon sp. nov. 相似文献
965.
Sanping Xie Bainian Sun David L. Dilcher Jingyu Wu Zhicheng Lin 《Review of Palaeobotany and Palynology》2010,162(2):193-202
Specimens of Palaeocarya (Juglandaceae) were collected from the upper Pliocene of western Yunnan Province, which is a new geographical and age range record of engelhardioid winged fruits in China. A numerical taxonomic investigation based on 14 morphological characters of fossil and extant specimens of engelhardioid winged fruits in China was conducted using multivariate methods. Phenetic clustering shows that there are four morphotypical groups which we assign to four species. Two groups are assigned to the previously described fossil species, Palaeocarya guangxiensis Li Hao-Min et Chen Yun-Fa, 2003 and Palaeocarya koreanica (Oishi) Manchester, 1987. Two new species are recognized, Palaeocarya yunnanensis and Palaeocarya longialata. These Neogene Engelhardieae fruits provide fossil data for understanding the origin and evolution of the Engelhardia species that now inhabit South China. 相似文献
966.
Gin-Ah Song Hyun-Jung Kim Kyung-Mi Woo Jeong-Hwa Baek Gwan-Shik Kim Jin-Young Choi Hyun-Mo Ryoo 《The Journal of biological chemistry》2010,285(29):22542-22553
Fibrodysplasia ossificans progressiva (FOP), a rare genetic and catastrophic disorder characterized by progressive heterotopic ossification, is caused by a point mutation, c.617G>A; p.R206H, in the activin A receptor type 1 (ACVR1) gene, one of the bone morphogenetic protein type I receptors (BMPR-Is). Although altered BMP signaling has been suggested to explain the pathogenesis, the molecular consequences of this mutation are still elusive. Here we studied the impact of ACVR1 R206H mutation on BMP signaling and its downstream signaling cascades in murine myogenic C2C12 cells and HEK 293 cells. We found that ACVR1 was the most abundant of the BMPR-Is expressed in mesenchymal cells but its contribution to osteogenic BMP signal transduction was minor. The R206H mutant caused weak activation of the BMP signaling pathway, unlike the Q207D mutant, a strong and constitutively active form. The R206H mutant showed a decreased binding affinity for FKBP1A/FKBP12, a known safeguard molecule against the leakage of transforming growth factor (TGF)-β or BMP signaling. The decreased binding affinity of FKBP1A to the mutant R206H ACVR1 resulted in leaky activation of the BMP signal, and moreover, it decreased steady-state R206H ACVR1 protein levels. Interestingly, while WT ACVR1 and FKBP1A were broadly distributed in plasma membrane and cytoplasm without BMP-2 stimulation and then localized in plasma membrane on BMP-2 stimulation, R206H ACVR1 and FKBP1A were mainly distributed in plasma membrane regardless of BMP-2 stimulation. The impaired binding to FKBP1A and an altered subcellular distribution by R206H ACVR1 mutation may result in mild activation of osteogenic BMP-signaling in extraskeletal sites such as muscle, which eventually lead to delayed and progressive ectopic bone formation in FOP patients. 相似文献
967.
湘东南栖霞组底部石炭-二叠纪有孔虫混生动物群的发现 总被引:1,自引:0,他引:1
首次报道湖南省邵东保和堂柳东地区栖霞组底部与史塔夫(Staffella)Ting类群共生的丰富的小有孔虫动物群,包括19属、62种,其中新种2个,该动物群具有非常典型的石炭-二叠纪有孔虫群的混生特点,称Bradyina-Geinitzina组合,它标志着“隆林阶”在湖南地区的首次发现。 相似文献
968.
依据福建龙岩坑柄煤矿童子岩组保存完好的化石材料,建立中二叠世(阳新统)蛇尾纲一新种--Aganaster?fujianensis sp.nov。,并根据蛇尾纲与腕足类,双壳类等共生化石组合的埋葬特征,认为古代蛇尾纲具有与现生蛇尾纲相似的集群而居的生活习性。 相似文献
969.
湖北宜昌大坪奥陶纪阿仑尼克期三叶虫生态组合 总被引:6,自引:2,他引:4
首次对扬子区奥陶纪大湾组的三叶虫相作了初步分析。在详细研究了湖北宜昌大坪大湾组30种三叶虫的地层和岩相分布的基础上,划分出3个生态组合,即:Asaphid-Pseudocalymene组合,Asaphid-Raphiophorid组合和Trinucleid组合,它们依次指示由浅而深的浅外陆棚环境。研究表明这3个组合在大湾组的交替出现应与阿仑尼克期海平面变化密切相关。 相似文献
970.
山西野生有毒植物组成 总被引:5,自引:1,他引:4
有毒植物是能引起人类或其它生物中毒死亡或有机体长期或暂时性伤害的植物。但是,有毒植物也有积极有益的一面.在人类生活、生产中起着很大作用。本文中重点介绍了山西有毒植物的组成.计47科、105属、150种.其中草本植物126种,木本植物24种.并对有毒部位与毒性作了说明.最后对有毒植物应用前景作了简要分析。 相似文献