山东植物志补遗(一)

报道了山东分布新记录科 1个 ,新记录属 1个 ,新记录种 1 2个 ,新记录变种 4个 ,新记录变型 1个。     

记山东曲阜中始新世晚期─雷兽新属种

描述了产自山东曲阜黄庄动物群-雷兽新材料：周氏曲阜雷兽（新属、新种）Qufutitanzhouigen．etspnov。该材料是山东省内首次确定的需兽属种报道,它与Metatelmatherium属相似但较之进步,是已知后沼雷兽亚科（Metatelmatheriinae）在沙拉木仑期的唯一代表,与中国沙拉木仑期特有的鼻雷兽属（Rhinotitan）差别较大。     

山东省蔷薇科植物分布新记录

本文报道了山东省蔷薇科植物分布新记录共３种１变种,即疏毛绣线菊Ｓｐｉｒａｅａｈｉｒｓｕｔａ（Ｈｅｍｓｌ．）Ｓｃｈｎｅｉｄ、金州绣线菊Ｓ．ｎｉｓｈｉｍｕｒａｅＫｉｔａｇ、庐山石楠Ｐｈｏｔｉｎｉａｖｉｌｏｓａｖａｒ．ｓｉｎｉｃａＲｅｈｄ．ｅｔＷｉｌｓ．和毛叶欧李Ｃｅｒａｓｕｓｄｉｃｔｙｏｎｅｕｒａ（Ｄｉｅｌｓ．）Ｙǖ．     

山东省蕨类植物的区系分析

对山东省蕨类植物区系成分、地理分布和生态特点进行了初步研究,并与辽宁、日本等６个地区进行了比较。结果表明,山东省蕨类植物区系具有以下几个特点：１．区系成分不算丰富,但地理成分多样,以温带成分占优势,也残存有较多的热带成分;２．种系分化强烈,特有现象明显,特有种占１１．３％;３．地理分布极不均匀,并存在明显的地带性差异,表现为由南向北、由东向西种类减少;４．与辽宁、北京、河南关系密切,与秦岭、日本也     

记山东沂南上新世熊属—新种

本文记述了产自山东沂南一洞穴堆积中的熊类化石一新种:Ursus yinanensis。这种熊具有个体较小,前臼齿数目全,下裂齿的下后尖之前尚未出现附尖等原始性特征,它与欧洲早上新世的Ursus boeckhi在进化程度上比较接近但更显进步。这是在中国首次发现的中上新世Ursus的可靠记录,它的发现对于探讨欧亚大陆上真正熊类的演化及地理分布等问题具有重要意义。     

山东新泰舌齿鱼科一新属、新种

本文记述了产自山东蒙阴盆地分水岭组中原始真骨鱼类—新属、新种——宁家沟谭氏鱼(Tanichthys ningjiagouensis gen. et sp. nov.).据其形态特征,它应归入舌齿鱼超科(Hiodontoidea),并与舌齿鱼科的成员接近.其生存时代很可能为早白垩世.     

山东刺肋跷蝽属一新种记述：半翅目：跷蝽科

1988年6月,在山东省烟台昆嵛山采到跷蝽科刺肋跷蝽属两头标本,经鉴定为1新种,现描述如下。模式标本存于内蒙古师范大学生物系。1.无纹刺肋跷蝽Metacanthus acinctus,新种(图1—9) 体狭长,黄褐色。头长0.60mm,宽0.42mm;颊部长超过复眼直径;头顶鼓,前端下倾,中叶长于侧叶;头背面横沟将头分为前后两叶,前叶长于后叶(6:2.5),后叶     

山东北部地区古新统孢粉组合*

统计了黄县地区龙口组和昌潍地区侯镇组孢粉100余个属种,描述6新种、4个新亚种,1个新联合种.在概述孢粉组合的基础上,重点讨论了该组合所代表的地质时代应属古新世.还阐述了这—孢粉植物群所反映的古气候特征.     

Dendritic Cells Pulsed with Exosomes in Combination with PD-1 Antibody Increase the Efficacy of Sorafenib in Hepatocellular Carcinoma Model

Advanced hepatocellular carcinoma (HCC) has limited therapeutic options. Immunotherapy is a promising treatment, while sorafenib is a first-line drug-based treatment for advanced HCC. However, the efficacy of sorafenib and immunotherapy in combination, have not been clearly evaluated. Sorafenib treatment has been shown to promote immunosuppression by increasing hypoxia in orthotopic HCC models. Here, we found that sorafenib treatment in mice with orthotopic HCC increased the expression of inhibitor programmed death-ligand 1 (PD-L1) and T-regulatory cells in tumor tissues. We pulsed dendritic cells with exosomes derived from tumor cells (DC-TEX) and found that the number of T-regulatory cells decreased and the number of CD8+T cells increased. However, combining DC-TEX and sorafenib did not prolong survival in these mice. Moreover, we found that the number of PD-1+CD8+T cells significantly increased after DC-TEX treatment. Therefore, we next added PD-1 antibody (PD-1 Ab) to the treatment regimen to block the PD-1/PD-L1 pathway, and found that the exhausted CD8+T cells were restored, without affecting the number of T-regulatory cells. Thus, our data suggest that the combination of DC-TEX and PD-1 Ab enhanced the efficacy of sorafenib, but treatment with either DC-TEX or PD-1 Ab alone, did not.     

A NEW NEOPLAGIAULACID MULTITUBERCULATE (MAMMALIA) FROM THE LOWER EOCENE OF WUTU BASIN, SHANDONG

TheWutuspecimenswerecol1ectedfromWutuFormation,LowerEoceneinl992andareconcurrentwithChangleIestcsdissetiformis(Insectivora,seeTongandWang,l993),ischyromyidrodents,carpo1estidprimates,primitiveperissodactylsandothermammals.MultituberculataCope,l884PtilodontoideaSloanandVanValen,l965NeoplagiauladdaeAmeghino,189oMesodmopsdaw8onaegen.etsp.nov.(Text-fig.l-2,Pl.l,II)TypeAfragmentaryskullwithrightdP1-M2andleftdP'-M',anear1ycompleterightmandiblewithI,andP'-M,,anincompleteleftmandiblewithP.…