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131.
Skin Innervation and Its Effects on the Epidermis 总被引:2,自引:0,他引:2
Hsieh ST Lin WM Chiang HY Huang IT Ko MH Chang YC Chen WP 《Journal of biomedical science》1997,4(5):264-268
Sensory innervation of the skin subserves protective sensations for the body to prevent thermal and noxious injuries. Neurophysiologically, they belong to the categories of A and C fibers, usually with caliber less than one µm in diameter. Morphological demonstration of the terminals of these nerves in the epidermis has been recognized recently by sensitive immunocytochemistry and an axonal marker, the protein gene product 9.5 (PGP). PGP is a ubiquitin C-terminal hydrolase, which is abundantly present in the nervous system, and particularly enriched in the unmyelinated nerves. Sensory nerves positive for PGP arise from the dorsal root ganglion, pass through the dermis, parallel the epidermis-dermis border, penetrate the basement membrane, move vertically and upwards in the epidermis with tortuous course and knobby appearance, and finally terminate at the granular layers of the epidermis. In rodents, denervation of the skin results in degeneration of epidermal nerves within 48 h of nerve transection, and thinning of the epidermis. In humans, application of this technique to evaluate disorders of the peripheral nervous system makes study of the degeneration of sensory nerve terminals possible. Patients with sensory neuropathy had fewer epidermal nerves than normal subjects, consistent with the notion of distal axonopathy. This approach has the potential to evaluate human sensory neuropathy in temporal and spatial domains. In addition, the influences of epidermal denervation open a new field to explore the interactions between sensory nerves and keratinocytes. 相似文献
132.
T. Ushizawa T. Nagayama M. Takahata 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1996,179(1):1-13
Electrical stimulation of mechanosensory afferents innervating hairs on the surface of the exopodite in crayfish Procambarus clarkii (Girard) elicited reciprocal activation of the antagonistic set of uropod motor neurones. The closer motor neurones were excited while the opener motor neurones were inhibited. This reciprocal pattern of activity in the uropod motor neurones was also produced by bath application of acetylcholine (ACh) and the cholinergic agonist, carbamylcholine (carbachol). The closing pattern of activity in the uropod motor neurones produced by sensory stimulation was completely eliminated by bath application of the ACh blocker, d-tubocurarine, though the spontaneous activity of the motor neurones was not affected significantly. Bath application of the acetylcholinesterase inhibitor, neostigmine, increased the amplitude and extended the time course of excitatory postsynaptic potentials (EPSPs) of ascending interneurones elicited by sensory stimulation. These results strongly suggest that synaptic transmission from mechanosensory afferents innervating hairs on the surface of the tailfan is cholinergic.Bath application of the cholinergic antagonists, dtubocurarine (vertebrate nicotinic antagonist) and atropine (muscarinic antagonist) reversibly reduced the amplitude of EPSPs in many identified ascending and spiking local interneurones during sensory stimulation. Bath application of the cholinergic agonists, nicotine (nicotinic agonist) and oxotremorine (muscarinic agonist) also reduced EPSP amplitude. Nicotine caused a rapid depolarization of membrane potential with, in some cases, spikes in the interneurones. In the presence of nicotine, interneurones showed almost no response to the sensory stimulation, probably owing to desensitization of postsynaptic receptors. On the other hand, no remarkable changes in membrane potential of interneurones were observed after oxotremorine application. These results suggest that ACh released from the mechanosensory afferents depolarizes interneurones by acting on receptors similar to vertebrate nicotinic receptors.Abbreviations
ACh
cetylcholine
-
mns
motor neurones
-
asc int
ascending interneurone 相似文献
133.
A female chimpanzee touched a button to produce colored slides of pictures. Slides were present as long as she kept touching
the button. Repeated touch within 10 sec after the previous release produced the same slides again. The slide was changed
when 10 sec passed after she released the button. The duration of a touching response and the interval between the responses
were calculated for each of 100 slides. The data for each slide were plotted on the two-dimensional space constructed with
response duration and response interval. A clear differentiation of distribution on this space was found between slides with
humans and those without humans. The result demonstrated that the chimpanzee recognized humans as a category, as well as that
this procedure is effective for the study of the perceptual world of animals based on the reinforcing function of stimuli. 相似文献
134.
Dr. R. W. Banks 《Cell and tissue research》1986,246(2):309-319
Summary The arrangement of preterminal and terminal axon branches in the primary sensory endings of cat tenuissimus muscle spindles was studied using whole-mount and serial-section techniques. Although in every case one firstorder preterminal branch was supplied exclusively to the bag1 type of intrafusal muscle fibre, the preterminal branching patterns differed considerably in detail.Terminals varied widely in size and location. Their precise form varied according to their position on the intrafusal muscle fibres rather than their relationship to preterminal branches. Terminals derived from separate preterminal branches remained separate and did not fuse with themselves or each other. Individually bag1 fibres had most terminals, chain fibres least. The surface of the muscle fibres were differentially indented by the terminals, least in bag1 fibres and most in chain fibres.The results are discussed in relation to mechanosensory transduction and to the factors involved in determining the form of the primary ending. 相似文献
135.
Résumé Chaque papille de la trompe chez Glycera convoluta contient un groupe central de deux à quatre cellules sensorielles primaires. Chaque cellule possède un noyau allongé situé à mi-hauteur de la papille. Le processus péripherique ou dendritique porte cinq à six cils qui traversent la cuticule et sont entourés chacun par un cercle de microvillosités; les cils se prolongent dans le cytoplasme par de fines racines ciliaires qui se réunissent pour former une seule énorme racine montrant une striation périodique. Le processus central ou axonal se prolonge dans le plexus nerveux sous-épithélial. Le rôle physiologique de ces cellules est discuté.
Sensory cells of the papillae in the proboscis of Glycera convoluta keferstein (Annelida, Polychaeta)
Summary Each papilla in the proboscis of Glycera convoluta contains a central group of two to four primary sensory cells. Each one shows an elongated nucleus situated at half-height of the papilla. The peripheric or dendritic process bears five to six cilia traversing the cuticle; each of them is circled by a ring of microvilli. The cilia are prolonged in the cytoplasm by fine ciliary rootlets which gather themselves in a very big single root showing a periodic striation. The central or axonal process runs in the subepithelial nervous plexus. The physiological role of the cells is discussed.相似文献
136.
Summary Following observation of conical groups of stiff, but motile cilia on the tentacles of the branchial crown of Sabella pavonina, these were examined with the electron microscope. The bundles consist of about 40 unenclosed standard cilia supported by one or two primary sense cells with centrally directed axons of 0.1–0.2 diameter. Axons in the distal portions of the branchial crown occur in small bundles surrounded by a basement membrane. More centrally, glial elements appear and the nerves are surrounded by a collagenous sheath. The branchial nerve trunk shows similarities in organisation to other previously investigated annelid central nervous tissue in that the whole nerve is surrounded by a fibrous sheath central to which there is a layer of glial cells with processes penetrating a central neuropile. The 0.1–0.2 axons commonly occur in glial-enveloped groups of < 40 whilst other axons of larger and mixed diameter are found together.Each tentacle has two branchial nerves on the oral side, and each nerve gives rise to two small 75-axon branches running to each pinnule. The branchial nerves fuse to form the branchial nerve trunk running to the supra-oesophageal ganglia.Sections of the branchial nerves of the branchial crown at progressively more central levels show that the branchial nerve trunk contains enough axons of 0.1–0.2 diameter to account for all the sensory cells on the tentacles. This is taken as evidence for the sensory cells having axons terminating within the central nervous system and that there is no peripheral confluence or fusion of these afferent axons. 相似文献
137.
Gudrun S. Bennett† Brian A. Hollander Danuta Laskowska Camille DiLullo† 《Journal of neurochemistry》1991,57(1):130-139
When cultured chick sensory neurons were labeled with [35S]methionine for 1 h or longer in the presence of 5-25 mM LiCl, we found a dose-dependent reduction in the level of radiolabeled tubulin, to one third of control levels, with no noticeable effect on other proteins. The magnitude of this response was identical after a 1-h or 72-h preincubation in 25 mM LiCl and returned to control values within 1 h after removal of LiCl. Short (5-min) pulse-chase experiments revealed that tubulin synthesis was not affected by Li+, but that newly synthesized tubulin was rapidly degraded, such that 50% of the labeled beta-tubulin was lost within 5 min. There was no enhanced degradation of tubulin present before exposure to Li+. Addition of LiCl at various times before and after a 10-min pulse suggested that tubulin becomes completely refractory to Li(+)-induced degradation within 10 min after translation. Although Li+ treatment resulted in a decrease in the fraction of extant tubulin present in the unassembled form, the Li(+)-induced degradation of nascent tubulin is not a consequence of shifts in assembly state, because colcemid or taxol treatment did not lead to rapid degradation of newly synthesized tubulin, and neither drug altered the response to Li+. We suggest that Li+ interferes with the correct folding of tubulin polypeptides, exposing sites, normally hidden, to the action of a protease(s). 相似文献
138.
目的:探讨感觉统合训练结合常规康复训练对痉挛型脑瘫患儿平衡控制及运动功能的影响。方法:选取2016年1月到2017年12月期间成都市妇女儿童中心医院康复科收治的痉挛型脑瘫患儿80例为研究对象,根据随机数字表法将80例患儿分为对照组(40例)和观察组(40例)。对照组患儿采用常规康复训练进行治疗,观察组患儿采用感觉统合训练结合常规康复训练进行治疗。比较两组脑瘫患儿的平衡控制功能、步态、粗大运动功能测试量表-88(GMFM-88)D区和E区的评分。结果:治疗3个月后两组患儿的Rivermead活动指数、Berg平衡量表得分均明显升高,且观察组患儿的Rivermead活动指数、Berg平衡量表得分高于对照组(P0.05)。治疗3个月后两组患儿的步行足长、步速明显增加,步宽明显减小(P0.05),且观察组患儿步行足长、步速大于对照组,步宽小于对照组(P0.05)。治疗3个月后两组患儿的GMFM-88 D区、GMFM-88 E区得分均分别明显升高(P0.05),且观察组患儿的GMFM-88 D区、GMFM-88 E区得分均分别高于对照组(P0.05)。结论:感觉统合训练结合常规康复训练可有效改善痉挛型脑瘫患儿的平衡控制功能、步态以及粗大运动功能。 相似文献
139.
Margarita Zachariou Dilshani W. N. Dissanayake Stephen Coombes Markus R. Owen Robert Mason 《Cognitive neurodynamics》2008,2(2):159-170
Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in
the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific
areas of the brain using multiple electrodes is helpful in the study of the neurobiology of sensory gating. In this paper,
we use such technology to investigate the role of cannabinoids in sensory gating in the CA3 region of the rat hippocampus.
Our experimental results show that application of the exogenous cannabinoid agonist WIN55,212-2 can abolish sensory gating.
We have developed a phenomenological model of cannabinoid dynamics incorporated within a spiking neural network model of CA3
with synaptically interacting pyramidal and basket cells. Direct numerical simulations of this model suggest that the basic
mechanism for this effect can be traced to the suppression of inhibition of slow GABAB synapses. Furthermore, by working with a simpler mathematical firing rate model we are able to show the robustness of this
mechanism for the abolition of sensory gating. 相似文献
140.
Caihong Xia Minh Nguyen Amy K. Garrison Zhen Zhao Zheng Wang Calum Sutherland Le Ma 《Developmental neurobiology》2013,73(9):673-687
The peptide hormone CNP has recently been found to positively regulate axon branching and growth via activation of cGMP signaling in embryonic dorsal root ganglion (DRG) neurons, but the cellular mechanisms mediating the regulation of these developmental processes have not been established. In this study, we provide evidence linking CNP/cGMP signaling to microtubule dynamics via the microtubule regulator CRMP2. First, phosphorylation of CRMP2 can be suppressed by cGMP activation in embryonic DRG neurons, and non‐phosphorylated CRMP2 promotes axon branching and growth. In addition, real time analysis of growing microtubule ends indicates a similar correlation of CRMP2 phosphorylation and its activity in promoting microtubule polymerization rates and durations in both COS cells and DRG neuron growth cones. Moreover, direct activation of cGMP signaling leads to increased assembly of dynamic microtubules in DRG growth cones. Finally, low doses of a microtubule depolymerization drug nocodazole block CNP/cGMP‐dependent axon branching and growth. Taken together, our results support a critical role of microtubule dynamics in mediating CNP/cGMP regulation of axonal development. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 673–687, 2013 相似文献