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581.
Dr. H. Björklund C. -J. Dalsgaard C. -E. Jonsson A. Hermansson 《Cell and tissue research》1986,243(1):51-57
Summary Non-hairy and hairy human skin were investigated with the use of the indirect immunohistochemical technique employing antisera to different neuronal and non-neuronal structural proteins and neurotransmitter candidates. Fibers immunoreactive to antisera against neurofilaments, neuron-specific enolase, myelin basic protein, protein S-100, substance P, neurokinin A, neuropeptide Y, tyrosine hydroxylase and vasoactive intestinal polypeptide (VIP) were detected in the skin with specific distributional patterns. Neurofilament-, neuron-specific enolase-, myelin basic protein-, protein S-100-, substance P-, neurokinin A-and vasoactive intestinal polypeptide (VIP)-like immunoreactivities were found in or in association with sensory nerves; moreover, neuron-specific enolase-, myelin basic protein-, protein S-100, neuropeptide Y-, tyrosine hydroxylase- and vasoactive intestinal polypeptide (VIP)-like immunoreactivities occurred in or in association with autonomic nerves. It was concluded that antiserum against neurofilaments labels sensory nerve fibers exclusively, whereas neuron-specific enolase-, myelin basic protein- and protein S-100-like immunoreactivities are found in or in association with both sensory and autonomic nerves. Substance P- and neurokinin A-like immunoreactivities were observed only in sensory nerve fibers, and neuropeptide Y- and tyrosine hydroxylase-like immunoreactivities occurred only in autonomic nerve fibers, whereas vasoactive intestinal polypeptide (VIP)-like immunoreactivity was seen predominantly in autonomic nerves, but also in some sensory nerve fibers. 相似文献
582.
In Drosophila, the sensory mother cells of macrochaetes are chosen from among the mitotically quiescent clusters of cells in wing imaginal
discs, where other cells are proliferating. The pattern of cyclin A, one of the G2 cyclins, reveals that mitotically quiescent
clusters of cells are arrested in G2. When precocious mitoses are induced during sensory mother cell determination by the
ectopic expression of string, a known G2/M transition regulator, the formation of sensory mother cells is disturbed, resulting in the loss of macrochaetes
in the adult notum. This suggests that G2 arrest of the cell cycle ensures the proper determination of sensory mother cells.
Received: 16 December 1996 / Accepted: 14 March 1997 相似文献
583.
Bernhard Zimmermann 《Cell and tissue research》1992,270(2):365-376
Summary In an attempt to identify and localize the components of voltage sources involved in sensory transduction in insect sensilla, the thermo-/hygrosensitive sensilla of the moth Antheraea pernyi were probed with a polyclonal antiserum against Na+,K+-ATPase in cryofixed and freeze-substituted preparations. The antiserum recognized epitopes on the cytoplasmic membranes of the dendritic inner segments and somata of the sensory cells and also on the cytoplasmic membranes of glial cells surrounding the initial axon segments. The findings support the current concept that ion pumps in the cytoplasmic membranes of the dendritic inner segments and somata of the sensory cells contribute to the maintenance of the resting potential of the sensory cells and to the driving forces generating the receptor currents in response to stimulation of the sensillum. Morphological features and immunohistochemical characteristics of the region of the initial axon segment are also discussed with respect to the initiation of action potentials in these sensilla. 相似文献
584.
James J. McKenna 《Human nature (Hawthorne, N.Y.)》1990,1(2):145-177
This paper and its subsequent parts (Part II and Part III) build on an earlier publication (McKenna 1986). They suggest that
important clinical data on the relationship between infantile constitutional deficits and microenvironmental factors relevant
to SIDS can be acquired by examining the physiological regulatory effects (well documented among nonhuman primates) that parents
assert on their infants when they sleep together.
I attempt to show why access to parental sensory cues (movement, touch, smell, sound) that induce arousals in infants while
they sleep could possibly help one of many different subclasses of infants either to override certain kinds of sleep-induced
breathing control errors suspected to be involved in SIDS or to avoid them altogether. I do not suggest that solitary nocturnal
sleep “causes” SIDS, that all parents should sleep with their infants, or that traditional SIDS research strategies should
be abandoned. However, using evolutionary data, I do suggest that an adaptive fit exists between parent-infant sleep contact
and the natural physiological vulnerabilities of the neurologically immature human infant, whose breathing system is more
complex than that of other mammals owing to its speech-breathing abilities. This “fit” is best understood, it is argued, in
terms of the 4–5 million years of human evolution in which parent-infant contact was almost certainly continuous during at
least the first year of an infant’s life. Thus, to dismiss the idea that solitary sleep has no physiological consequences
for infants does not accord with scientific facts.
James J. McKenna is Associate Professor of Anthropology and Chair of the Department of Sociology and Anthropology at Pomona
College. He also has an appointment as an Adjunct Clinical Assistant Professor in the Departments of Pediatrics, Child Psychiatry,
and Human Behavior at the University of California, Irvine, School of Medicine. His primary research interests and many of
his publications concern aspects of primate parenting and infant development among both human and nonhuman primates. For the
past seven years he has been investigating from an anthropological perspective possible environmental correlates of the sudden
infant death syndrome (SIDS) and has just finished a preliminary study on the physiological correlates of human parent-infant
co-sleeping. His earlier monograph on the subject (cited in this paper) has received much international attention. He and
his colleagues (Mosko and Dungy) are the first to have used standard polysomnographic techniques to document simultaneously
human parent-infant co-sleeping. He has won three awards for distinguished teaching at Pomona College. 相似文献
585.
Sequence analysis of a newly isolated Hirudo medicinalis cDNA containing an Antennapedia (Antp)-class homeobox suggests that the corresponding gene, Lox6, is an ortholog of the Drosophila
Deformed (Dfd) gene. In situ hybridization of whole-mounted preparations shows that the major sites of Lox6 expression during embryogenesis are the central nervous system (CNS) and the peripheral sensory system. Lox6 mRNA can be detected in a subset of neurons in each ganglion from the subesophageal ganglion (RG2) to the most posterior
ganglion, with the highest level of expression seen in RG3. Peripherally, Lox6 is expressed principally in the primordia of the sensillae and in the eyes. This pattern of expression of Lox6 suggests that one of its functions may be to contribute to the diversification of neuronal phenotypes.
Received: 16 August 1997/Accepted: 20 December 1997 相似文献