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991.
992.
Qiang Fu a b Peijiang Zhang b Lubin Tan a Zuofeng Zhu a Dan Ma a Yongcai Fu a Xinchun Zhan b Hongwei Cai a Chuanqing Sun a a State Key Laboratory of Plant Physiology Biochemistry National Center for Evaluation of Agricultural Wild Plants Laboratory of Crop Heterosis Utilization of Ministry of Education Beijing Key Laboratory of Crop Genetic Improvement Key Laboratory of Crop Genetic Improve-ment Genome of Ministry of Agriculture 《Acta Genetica Sinica》2010,(2)
993.
S. H. Phua K. G. Dodds C. A. Morris H. M. Henry A. E. Beattie H. G. Garmonsway N. R. Towers A. M. Crawford 《Animal genetics》2009,40(1):73-79
Facial eczema (FE) is a secondary photosensitization disease arising from liver cirrhosis caused by the mycotoxin sporidesmin. The disease affects sheep, cattle, deer and goats, and costs the New Zealand sheep industry alone an estimated NZ$63M annually. A long-term sustainable solution to this century-old FE problem is to breed for disease-resistant animals by marker-assisted selection. As a step towards finding a diagnostic DNA test for FE sensitivity, we have conducted a genome-scan experiment to screen for quantitative trait loci (QTL) affecting this trait in Romney sheep. Four F1 sires, obtained from reciprocal matings of FE resistant and susceptible selection-line animals, were used to generate four outcross families. The resulting half-sib progeny were artificially challenged with sporidesmin to phenotype their FE traits measured in terms of their serum levels of liver-specific enzymes, namely gamma-glutamyl transferase and glutamate dehydrogenase. In a primary screen using selective genotyping on extreme progeny of each family, a total of 244 DNA markers uniformly distributed over all 26 ovine autosomes (with an autosomal genome coverage of 79–91%) were tested for linkage to the FE traits. Data were analysed using Haley–Knott regression. The primary screen detected one significant and one suggestive QTL on chromosomes 3 and 8 respectively. Both the significant and suggestive QTL were followed up in a secondary screen where all progeny were genotyped and analysed; the QTL on chromosome 3 was significant in this analysis. 相似文献
994.
《American journal of human genetics》2020,106(2):170-187
995.
996.
《Animal : an international journal of animal bioscience》2016,10(4):550-557
Both growth and immune capacity are important traits in animal breeding. The animal quantitative trait loci (QTL) database is a valuable resource and can be used for interpreting the genetic mechanisms that underlie growth and immune traits. However, QTL intervals often involve too many candidate genes to find the true causal genes. Therefore, the aim of this study was to provide an effective annotation pipeline that can make full use of the information of Gene Ontology terms annotation, linkage gene blocks and pathways to further identify pleiotropic genes and gene sets in the overlapping intervals of growth-related and immunity-related QTLs. In total, 55 non-redundant QTL overlapping intervals were identified, 1893 growth-related genes and 713 immunity-related genes were further classified into overlapping intervals and 405 pleiotropic genes shared by the two gene sets were determined. In addition, 19 pleiotropic gene linkage blocks and 67 pathways related to immunity and growth traits were discovered. A total of 343 growth-related genes and 144 immunity-related genes involved in pleiotropic pathways were also identified, respectively. We also sequenced and genotyped 284 individuals from Chinese Meishan pigs and European pigs and mapped the single nucleotide polymorphisms (SNPs) to the pleiotropic genes and gene sets that we identified. A total of 971 high-confidence SNPs were mapped to the pleiotropic genes and gene sets that we identified, and among them 743 SNPs were statistically significant in allele frequency between Meishan and European pigs. This study explores the relationship between growth and immunity traits from the view of QTL overlapping intervals and can be generalized to explore the relationships between other traits. 相似文献
997.
J. Pauquet A. Bouquet P. This A.-F. Adam-Blondon 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》2001,103(8):1201-1210
The monogenic dominant genetic determinism of total resistance to powdery mildew, introduced from Muscadinia
rotundifolia into Vitis
vinifera, was further assessed in BC4 and BC5 full-sib families. A BC5 population of 157 individuals was used to select AFLP markers linked to the resistance gene, Run1. Thirteen AFLP markers were selected and a local map was constructed around the Run1 gene. Ten markers among the 13 were found to co-segregate with the resistance gene. The usefulness of these 13 AFLP markers
for the selection of Run1-carrying genotypes was further assessed through their analysis in a set of 22 Run1-carrying resistant genotypes and 16 susceptible genotypes. Three markers out of the 13 analysed were found to be absent
in all susceptible genotypes and present in all resistant individuals, and may thus represent good tools for the marker-assisted
selection of grapevine varieties resistant to powdery mildew. A recombination event among the markers that were originally
found to co-segregate was observed in one of the resistant individuals, showing that recombination is possible in this region
and may therefore be observed in larger populations.
Received: 18 October 2000 / Accepted: 4 April 2001 相似文献
998.
Molecular markers in plant ecology 总被引:9,自引:1,他引:8
KONRAD BACHMANN 《The New phytologist》1994,126(3):403-418
999.
1. The persistence of both geographical and reproductive boundaries between related species poses a fundamental puzzle in biology. Reproductive interactions between species can have a substantial impact on the maintenance of a boundary, potentially contributing to its collapse (e.g. via hybridisation) or facilitating reproductive isolation (e.g. via reinforcement). 2. The degree to which two parapatric insect species in the genus Phymata are reproductively isolated was evaluated and several mechanisms that could contribute to the maintenance of species boundaries were assessed. 3. Behavioural assays showed no indication of species‐assortative mating, nor any fecundity costs associated with heterospecific mating. Thus, there was no evidence of prezygotic mechanisms of reproductive isolation between the two species. 4.In laboratory crosses, it was found that the two species were indeed capable of producing viable F1 hybrids. Morphologically, these hybrids were phenotypically intermediate to the two parental species, and similar to the phenotypes seen in natural populations thought to occur in a hybrid zone. F1 hybrids did not show reduced viability, although there was some suggestion of ‘hybrid breakdown’, evident from the lower viability observed for progeny of ‘natural hybrids’. 5. Collectively, we show that despite genetically based morphological differences between species, P. americana and pennsylvanica can, and probably do hybridise. More studies are needed to understand the mechanisms that maintain the distinct phenotypes and geographical ranges of these species, despite the considerable potential for introgression. 相似文献
1000.