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681.
M.A. Aon S. Cortassa F.G. Akar D.A. Brown L. Zhou B. ORourke 《The international journal of biochemistry & cell biology》2009,41(10):1940-1948
The reactive oxygen species (ROS)-dependent mitochondrial oscillator described in cardiac cells exhibits at least two modes of function under physiological conditions or in response to metabolic and oxidative stress. Both modes depend upon network behavior of mitochondria. Under physiological conditions cardiac mitochondria behave as a network of coupled oscillators with a broad range of frequencies. ROS weakly couples mitochondria under normal conditions but becomes a strong coupling messenger when, under oxidative stress, the mitochondrial network attains criticality. Mitochondrial criticality is achieved when a threshold of ROS is overcome and a certain density of mitochondria forms a cluster that spans the whole cell. Under these conditions, the slightest perturbation triggers a cell-wide collapse of the mitochondrial membrane potential, Δψm, visualized as a depolarization wave throughout the cell which is followed by whole cell synchronized oscillations in Δψm, NADH, ROS, and GSH. This dynamic behavior scales from the mitochondrion to the cell by driving cellular excitability and the whole heart into catastrophic arrhythmias. A network collapse of Δψm under criticality leads to: (i) energetic failure, (ii) temporal and regional alterations in action potential (AP), (iii) development of zones of impaired conduction in the myocardium, and, ultimately, (iv) a fatal ventricular arrhythmia. 相似文献
682.
David Welch 《Plant Ecology & Diversity》2013,6(1):75-76
Summary Work fulfilling actions and research specified in the Biodiversity Action Plan for SaxÍfraga hirculus is described. Two recovery sites have been set up in suitable mires situated within 3 km of lost sites. Seeds from two of the three remaining N. Scottish sites germinated readily, and plants were successfully propagated in a garden. Transplanting to the first recovery site began in 1996 and to the second in 2000. Transplants survived well and increased in size, with some flowering. Direct sowing of seeds to the recovery sites was less successful, with poor survival and very slow growth of seedlings. Competition from resident mire plants is thought to control the performance of the transplants, growth being most checked in hummocks of Sphagnum warnstorfii. Ideally transplants should have c. 100 cm2 basal area. 相似文献
683.
Summary Machair is a complex dune grassland habitat confined to Scotland and Ireland. With two-thirds of the world area of machair in Scotland, the UK has a special responsibility for this resource, and the UK Machair Habitat Action Plan identifies a range of realistic management targets and actions aimed at protecting and enhancing the habitat. Machair's conservation importance is substantially reliant on active, traditional management, but quantitative and location-based information on management is rarely available, and this will have an impact on any numerical targets in the Plan. Though progress has been made on many of the actions, further measurable progress will very much depend, not only on improvements in the information base, but also in the understanding of relationships between land use and biodiversity. Progress to date on actions and targets is evaluated, and problems are identified. 相似文献
684.
685.
Intramuscular pressure (IMP) reflects forces produced by a muscle. Age is one of the determinants of skeletal muscle performance. The present study aimed to test whether IMP mirrors known age-related muscular changes. We simultaneously measured the tibialis anterior (TA) IMP, compound muscle action potential (CMAP), and ankle torque in thirteen older adults (60–80 years old) in vivo by applying different stimulation intensities and frequencies. We found significant positive correlations between the stimulation intensity and IMP and CMAP. Increasing stimulation frequency caused ankle torque and IMP to increase. The electromechanical delay (EMD) (36 ms) was longer than the onset of IMP (IMPD) (29 ms). Compared to the previously published data collected from young adults (21–40 years old) in identical conditions, the TA CMAP and IMP of older adults at maximum intensity of stimulation were 23.8% and 39.6% lower, respectively. For different stimulation frequencies, CMAP, IMP, as well as ankle torque of older adults were 20.5%, 24.2%, and 13.2% lower, respectively. Surprisingly, the EMD did not exhibit any difference between young and older adults and the IMPD was consistent with the EMD. Data supporting the hypotheses suggest that IMP measurement is an indicator of muscle performance in older adults. 相似文献
686.
The leaf lamina ofLavatera cretica L. exhibits a diaphototropic response that discriminates between two opposite, constant vectorial excitations by white light
beams whose fluence rates differ by as little as 10% (50 versus 45 μmol·m−2·S−1). The relationship between the response (angular velocity of laminar reorientation) and the fluence-rate ratio is linear.
The lamina similarly discriminates between two such excitations by polarized light, one with the electrical vector transverse
to the plane of the two beams (θ) and the opposite one with the vector parallel to that plane (⪙). When two such beams were
of equal fluence rate, the lamina reoriented towards the ⪙ beam. When the fluence rate of the θ beam was maintained at 50
μmol·m−2·s−1 and that of the ⪙ beam was reduced, the response to the latter (angular velocity of laminar reorientation) was reduced progressively.
Further reduction in the fluence rate of the ⪙ polarized beam eventually resulted in reorientation in the opposite direction
(towards the θ beam) and the response to the latter increased progressively with the reduction in fluence rate. The equilibrium
was at a ⪙/θ ratio of 0.62. Measurements of reflectance of oblique beams of ⪙ and θ polarized light from the upper laminar
surface, and of transmittance of such light ghrough the lamina, eliminated the possibility that optical dichroism of the lamina
contributed significantly to these results. The implications of this action dichroism to the postulated mechanism of perception
of vectorial excitation by these leaves is discussed.
Dedicated to the 60thbirth day of Professor Hans Mohr 相似文献
687.
The economics of control of grain aphid (Sitobion avenae) and rose-grain aphid (Metopolophium dirhodum) were investigated in a series of experiments carried out across England in 1988 and 1989. Sprays of pirimicarb or dimethoate were applied at three growth stages and yield effects measured. Aphid infestations were determined by a range of different methods, to evaluate the value of each for decision making. Aphids overwintered in crops in mild conditions in both seasons, resulting in early population build-up and decline in many cases. Aphicide sprays applied during the booting stage increased average yields by 0.26 t/ha. Profitability of the treatment strategies considered was not greatly enhanced by selective spray application related to aphid assessment at this stage. Delaying decision making to the flowering or grain-filling stages resulted in reduced profitability. A poor correlation between aphid numbers and crop yield response to sprays was found. This was shown to be due to differences in subsequent aphid population development and in aphicide efficacy. Grain quality was affected only by high aphid infestations which caused large yield reductions. 相似文献
688.
ACTH 1-39 (0.2 U IP daily for up to 18 days) has a beneficial effect on the functional reorganization of regenerating motor units of the extensor digitorum longus (EDL) in the adrenalectomized adult rat following crushing of the peroneal nerve. Motor unit activity (maximum twitch tension amplitude/mean increment in twitch tension as voltage is increased by 0.1 V gradations) and nerve-muscle efficiency (tetanic tension from indirect stimulation/tetanic tension from direct stimulation of EDL) were enhanced by ACTH 1-39. Other electrophysiological and contractile parameters were unaffected by the peptide. Spontaneous motor activity in cold stressed 13 day old rats was prolonged by Org 2766, a substituted analogue of ACTH/MSH 4-9, (0.1 microgram/kg daily) but unaffected by the same dosage of ACTH/MSH 4-10. The responsiveness of developing and regenerating motor systems to neuropeptides indicates a plasticity of neuronal connections, which depends on peptide sequence, dosage and the physiological state of the animal (normal, depressed, regenerating or developing, at rest or stressed). 相似文献
689.
690.
In young Acetabularia mediterranea Lamouroux (=A. acetabulum (L.) Silva) the formation of the lateral hair whorls can be induced by a short pulse of blue light after continuous red preillumination. In this paper we describe the experimental conditions for optimum response and the properties of the action spectrum. The probit of the cells which eventually form hair whorls is linearly correlated to the logarithm of the incident quanta of blue light. Parallel fluence-response curves for all wavelengths indicate the involvement of only one photoreceptor pigment. The action spectrum shows no effectiveness of wavelengths above 520 nm, a high action peak at 470 nm and two lower ones at 425 and 370 nm, and is in accordance with those of cryptochrome-like photoreceptors. 相似文献