Philosophy of science, policy sciences and the basis of decision support with LCA Based on the toxicity controversy in Sweden and the Netherlands

Current LCA implicitly assumes that a single rational truth can be found. Mainstream policy sciences has taken a different starting point when analysing decision making in complex and controversial societal debates for already several decades. In such debates, in general, more than one reasonable conceptualisation or ‘framing’ of the problem is at stake which forms the core of the controversy. This paper analyses the Dutch chlorine debate and the Swedish PVC debate and shows that (three) frames also play a role in toxicity controversies: the risk assessment frame, the strict control frame, and the precautionary frame. The latter frame, adhered to by the environmentalists, seeks to judge substances mainly on their inherent safety. The cases show that this logic may be defended as at least being equally reasonable to the emission-effect calculations that form the core of Risk Assessment and Life-cycle Impact Assessment (LCIA). As predicted by policy sciences, this finding implies that the political neutrality of tools like LCIA is questionable. In summary, the approaches and procedures developed for LCA have to be reconciled with key lessons from policy science and philosophy of science, i.e. considering the fact that multiple realities play a key role in many decision making processes. This paper suggests some alternative indicators for toxicity evaluations, and indicates the implications of LCA method development.     

Left Atrial Appendage Dysfunction in a Patient with Premature Ventricular Contractions - A Risk Factor for Stroke?

A 16-year-old female with ventricular dysfunction and frequent ventricular arrhythmia presented with a cardioembolic stroke. Prior electrophysiology study and ablation was performed for ventricular tachycardia (VT). For remaining ventricular ectopy, the patient was maintained on carvedilol and mexiletine. After one year on this regimen, she presented with an acute stroke. Transesophageal echocardiography revealed no evidence of an intracardiac or ventricular thrombus but demonstrated markedly decreased left atrial appendage (LAA) flow velocity worsened during frequent premature ventricular contractions (PVC). In the absence of atrial fibrillation (AF), the LAA dysfunction was considered secondary to the frequent PVCs and was thought to be the underlying cause for the stroke. We present this case to highlight a potential under recognized association between LAA dysfunction and ventricular arrhythmia, similar to that observed with atrioventricular dyssynchronous pacing.     

应用PVC防护套防御退耕还林区幼龄林木鼠害

本文报道了PVC 防护套对鼠类危害内蒙古退耕还林区幼龄林的防护作用,目的在于检验其是否能用于治理退耕还林区鼠类对林木的危害。2004 年9 月至2005 年4 月,在内蒙古自治区巴彦淖尔市杭锦后旗的退耕还林区进行防护实验,逐月调查危害情况。结果表明,本地区鼠类的危害期主要为9 月至11 月,累计危害率为34.25%, 其中9 月份的危害最严重,危害率高达17.42% ;该防护套可有效防止林业鼠类对林木的危害,实验期间未发现一例树木受到鼠类的危害,同时,PVC 防护套亦未增加其它树木受到危害的概率。建议在每年的9月之前对树木采取防护措施,以提高其对树木的防护效率。     

Tricuspid annular PVCS: Radiofrequency ablation by subtricuspid retrograde catheter approach

Tricuspid annular PVCs constitute 8% of idiopathic PVCs and 5% of RV PVCs. Although a rare entity to encounter in routine clinical practice, it can be a prime culprit behind major arrhythmic burden in few individuals. Electroanatomic approach with sub tricuspid retrograde catheter technique can target those annular PVCs and decrease the arrhythmia burden to normal or near normal range. Although procedural approach for parahisian PVCs requires a close look to avoid injury to native conduction system, TA PVCs are a real challenge due to inherent catheter instability and contact issue in sub tricuspid retrograde approach.     

Increases in permeability of Escherichia coli outer membrane induced by polycations

The action of polycations (such as polylysine and compound 48/80) on Escherichia coli was studied with use of Ca2+, K+ and TPP+ ion-selective electrodes. Rapid efflux of Ca2+ was observed when a polycation was added in cell suspension. The polycation treatment promoted a drug-inducing K+ release from the cytoplasmic membrane. TPP+ uptake was also increased by addition of a polycation. Without the polycation treatment, the uptake of TPP+ was largely suppressed due to a permeability barrier of the outer membrane. The results show that a polycation disrupted the permeability barrier of the outer membrane.