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141.
Ovarian steroids and oxytocin (OT) have been implicated in the regulation of social behaviors. The purpose of the present study was to examine hormonal substrates of aggression and affiliation in the female Mongolian gerbil (Meriones unguiculatus), a highly social, monogamous rodent. Sexually naive adult females were paired with sexually experienced males for 48 h and their interactions videotaped. Females were gonadally intact and tested during vaginal estrus (INT) or ovariectomized and observed after the following treatments, administered by means of sc injections: EBEB (7 days of estradiol-benzoate); EBP (2 days of EB followed by progesterone), SALEB (saline, days 1-5 then 2 days of EB), OTEB (OT for days 1-5 then 2 days of EB); OTOIL (OT for days 1-5 then 2 days of OIL); or SALOIL (saline days 1-5 then 2 days of OIL). During the first hour of pairing INT females displayed higher levels of affiliation and lower levels of sniffing and agonistic behavior than SALOIL females. All hormonal treatments reduced agonistic behaviors when compared to SALOIL, although none of the hormonal treatments restored affiliation to INT levels. During the 48-h test overt aggression varied by treatment with INT, EBEB, EBP, and OTEB females displaying lower levels than SALOIL, while all groups displayed similar levels of affiliation. The results indicate that OT and E play a significant role in regulating male-directed aggressive behavior in females and that the presence of ovarian hormones as well as OT can increase affiliation during initial contact. Over a sustained period of cohabitation social cues appear to be more important in regulating affiliation than gonadal hormones.  相似文献   
142.
Two genes of the oxytocin/vasopressin superfamily in the cephalopod Octopus vulgaris, cephalotocin (CT) and octopressin (OP), lack introns and consist of a single exon in their protein-coding regions, which is unlike the 2 intron-3 exon structures in most vertebrates and Lys-conopressin in a pond snail Lymnaea stagnalis. Octopus may have lost introns during the evolutionary process in mollusks. mRNA that had deleted 202 bp from preproCT cDNA (CT-del) was also expressed in the brain. The deletion occurred in the central part of neurophysin. Immunohistochemical studies suggest that a translational product of CT-del mRNA may not be present in a stable form due to the loss of neurophysin. Genomic Southern blot analysis revealed that a single copy of each of OP-, CT-, and CT-del-genes was present in the genome.  相似文献   
143.
We hypothesize that rapid eye movement or REM sleep evolved, in part, to mediate sexual/reproductive behaviors and strategies. Because development of sexual and mating strategies depends crucially on early attachment experiences, we further hypothesize that REM functions to mediate attachment processes early in life. Evidence for these hypotheses comes from (1) the correlation of REM variables with both attachment and sexual/reproductive variables; (2) attachment-related and sex-related hormonal release during REM; (3) selective activation during REM of brain sites implicated in attachment and sexual processes; (4) effects of maternal deprivation on REM; (5) effects of REM deprivation on sexual behaviors; and (6) the REM-associated sexual excitation. To explain why we find associations among REM sleep, attachment, and adult reproductive strategies, we rely on recent extensions of parent-offspring conflict theory. Using data from recent findings on genomic imprinting, Haig (2000) and others suggest that paternally expressed genes are selected to promote growth of the developing fetus/child at the expense of the mother, while maternally expressed genes counter these effects. Because developmental REM facilitates attachment-related outcomes in the child, developmental REM may be regulated by paternally expressed genes. In that case, REM may have evolved to support the “aims” of paternal genes at the expense of maternal genes. Patrick McNamara, Ph.D., is an assistant professor of neurology at Boston University School of Medicine and a member of the Department of Neurology at the Boston VA Medical Center. He specializes in study of catecholaminergic mechanisms of cognitive disorders in Parkinson’s and related disorders. He has a long-standing interest in anthropological and evolutionary approaches to medicine and to human cognition. His recent book Mind and Variability applied Darwinian models to problems of memory and identity. He is currently writing a book on the evolutionary psychology of sleep and dreams. Sanford Auerbach, M.D., is an associate professor of neurology and psychiatry at Boston University School of Medicine and medical director of the Neurophysiology Laboratories at the Boston Medical Center. He is a behavioral neurologist and a board-certified sleep specialist. He is also director of the Sleep Disorders Center at Boston Medical Center. He has been associated with the NIH-sponsored Sleep Heart Health Study and other sleep-related research. He has been a member of the executive committee of the Sleep Section of the American Academy of Neurology and a past chair of the Neurology section of the American Sleep Disorders Association. Jayme Dowdall is a medical student at Boston University School of Medicine who plans to specialize in molecular approaches to medical and sleep disorders.  相似文献   
144.
Maternal behavior in the goat appears at the time of parturition, partly under the activating influence of vaginocervical stimulation. Mothers actively lick their neonate and rapidly establish a selective bond with their kid through olfactory recognition. They also develop visual and acoustic recognition of the kid within 4 h following birth. Acoustic recognition is present at 48 h. The establishment of maternal recognition can be impaired by underfeeding during the second half of pregnancy. There is no indication that the mechanisms controlling the onset of maternal behavior and bonding are different from those reported in sheep, despite the fact that lambs start to follow their mother within a few hours after birth and kids hide for about a week. During lactation, the cues provided by the kid are necessary for the maintenance of maternal responsiveness, but suckling itself does not appear of primary importance. The presence of the kid also modulates the hormonal response to udder stimulation and influences recovery of postpartum sexual activity when kidding (i.e. birthing) takes place in autumn. Finally, the rapid establishment of mutual attachment between mother goats (does) and their kids offers the possibility to investigate an aspect of mother-young affiliation that is not present in many laboratory species.  相似文献   
145.
Magnocellular neuroendocrine cells (MNCs) of the hypothalamus synthesize the neurohormones vasopressin and oxytocin, which are released into the blood and exert a wide spectrum of actions, including the regulation of cardiovascular and reproductive functions. Vasopressin- and oxytocin-secreting neurons have similar morphological structure and electrophysiological characteristics. A realistic multicompartmental model of a MNC with a bipolar branching structure was developed and calibrated based on morphological and in vitro electrophysiological data in order to explore the roles of ion currents and intracellular calcium dynamics in the intrinsic electrical MNC properties. The model was used to determine the likely distributions of ion conductances in morphologically distinct parts of the MNCs: soma, primary dendrites and secondary dendrites. While reproducing the general electrophysiological features of MNCs, the model demonstrates that the differential spatial distributions of ion channels influence the functional expression of MNC properties, and reveals the potential importance of dendritic conductances in these properties. Action Editor: Eric De Schutter  相似文献   
146.
In the present study, the distribution of P2X receptor protein and colocalization of P2X receptors with vasopressin and oxytocin in the supraoptic and paraventricular nuclei of rat hypothalamus was studied using double-labeling fluorescence immunohistochemistry. The results showed that vasopressin-containing neurons expressed P2X2, P2X4, P2X5 and P2X6 receptor and oxytocin-containing neurons expressed P2X2, P2X4 and P2X5 receptors in the supraoptic nucleus. In the paraventricular nucleus, vasopressin-containing neurons expressed P2X4, P2X5 and P2X6 receptors, while oxytocin-containing neurons expressed P2X4 receptors. This study provides the first evidence that P2X receptor subunits are differentially expressed on vasopressin- and oxytocin-containing neurons in the supraoptic and paraventricular nuclei, and hence, provides a substantial neuroanatomical basis for possible functional interactions between the purinergic and vasopressinergic systems, and the purinergic and oxytocinergic systems in the rat hypothalamus. Wei Guo and Jihu Sun contributed equally to this work.  相似文献   
147.
摘要 目的:探讨双腔水囊联合腹主动脉介入阻隔术对比催产素联合常规剖宫产对于晚期妊娠糖尿病引产的临床疗效。方法:收集2019年9月至2020年4月在我院待产的146例晚期妊娠糖尿病患者,随机分为研究组(73例)和对照组(73例)。研究组首先采用双腔水囊置于宫颈引产,对于双腔水囊引产失败的患者则采用腹主动脉介入阻隔术情况下剖宫产;对照组采用单纯静脉滴注小剂量催产素引产,对于催产素引产失败的患者则行常规剖宫产。通过询问病史、体征检查、实验室检查等收集孕妇一般情况、引产前后宫颈Bishop评分、各产程情况、不良反应等数据;引产失败的部分患者收集手术时间、输血量、出血量、子宫切除率、新生儿Apgar评分。对比分析两组患者促宫颈成熟度、各产程情况、妊娠结局、不良反应等结果。结果:研究组孕妇宫颈Bishop评分治疗后高于对照组(P<0.05);研究组与对照组在宫颈Bishop评分提高上比较差异有统计学意义(P<0.05)。研究组引产成功率高于对照组,对照组剖宫产率高于研究组,两组分娩结局比较差异有统计学意义(P<0.05)。研究组引产开始至临产时间、第一产程、第二产程、总产程时间上短于对照组(P<0.05)。研究组术中出血量、输血量、子宫切除率及新生儿Apgar评分均少于对照组(P<0.05)。研究组不良反应发生例数低于对照组(P<0.05)。结论:双腔水囊、催产素均可促宫颈成熟,但前者优于后者且可提高引产成功率;腹主动脉介入阻隔术的应用较常规剖宫产优势更为明显,对于晚期妊娠糖尿病孕妇采用双腔水囊联合腹主动脉介入阻隔术引产具有更高安全性,值得临床借鉴。  相似文献   
148.
The role of the noradrenergic nucleus Locus Coeruleus (LC) on hemorrhage-induced vasopressin (AVP) and oxytocin (OT) secretion was examined. Rats with LC lesion were submitted to three 1-min hemorrhage sessions at 5-min intervals; 15% of the total blood volume was withdrawn in each session. OT and AVP were measured in plasma, paraventricular (PVN) and supraoptic (SON) nuclei and in posterior pituitary (PP). LC Lesion did not affect basal plasma AVP or OT levels, but partly blocked the increase in plasma AVP and OT induced by hemorrhage. Hemorrhage produced decreases in content of AVP and OT in the PVN and SON and increased levels in the PP. These responses were attenuated in the lesioned group, but only in the PVN and PP. Data suggest a stimulatory role of the inputs from LC to PVN neurons on hemorrhage-induced OT and AVP secretion and that, this pathway is critical in the hypo-volemic neuroendocrine reflex.Special Issue Dedicated to Miklós Palkovits.  相似文献   
149.
《Cell calcium》2016,60(6):280-288
The magnocellular vasopressin (AVP) and oxytocin (OT) neurones exhibit specific electrophysiological behaviour, synthesise AVP and OT peptides and secrete them into the neurohypophysial system in response to various physiological stimulations. The activity of these neurones is regulated by the very same peptides released either somato-dendritically or when applied to supraoptic nucleus (SON) preparations in vitro. The AVP and OT, secreted somato-dendritically (i.e. in the SON proper) act through specific autoreceptors, induce distinct Ca2+ signals and regulate cellular events. Here, we demonstrate that about 70% of freshly isolated individual SON neurones from the adult non-transgenic or transgenic rats bearing AVP (AVP-eGFP) or OT (OT-mRFP1) markers, produce distinct spontaneous [Ca2+]i oscillations. In the neurones identified (through specific fluorescence), about 80% of AVP neurones and about 60% of OT neurones exhibited these oscillations. Exposure to AVP triggered [Ca2+]i oscillations in silent AVP neurones, or modified the oscillatory pattern in spontaneously active cells. Hyper- and hypo-osmotic stimuli (325 or 275 mOsmol/l) respectively intensified or inhibited spontaneous [Ca2+]i dynamics. In rats dehydrated for 3 or 5 days almost 90% of neurones displayed spontaneous [Ca2+]i oscillations. More than 80% of OT-mRFP1 neurones from 3 to 6-day-lactating rats were oscillatory vs. about 44% (OT-mRFP1 neurones) in virgins. Together, these results unveil for the first time that both AVP and OT neurones maintain, via Ca2+ signals, their remarkable intrinsic in vivo physiological properties in an isolated condition.  相似文献   
150.
Maternal licking in rats affects the development of the spinal nucleus of the bulbocavernosus (SNB), a sexually dimorphic motor nucleus that controls penile reflexes involved with copulation. Reduced maternal licking results in decreased motoneuron number, size, and dendritic length in the adult SNB, as well as deficits in adult male copulatory behavior. Our previous findings that licking-like tactile stimulation influences SNB dendritic development and upregulates Fos expression in the lumbosacral spinal cord suggest that afferent signaling is changed by differences in maternal stimulation. Oxytocin afferents from the hypothalamus are a possible candidate, given previous research that has shown oxytocin is released following sensory stimulation, oxytocin modulates excitability in the spinal cord, and is a pro-erectile modulator of male sex behavior. In this experiment, we used immunofluorescence and immediate early gene analysis to assess whether licking-like tactile stimulation of the perineum activated parvocellular oxytocinergic neurons in the hypothalamus in neonates. We also used enzyme immunoassay to determine whether this same stroking stimulation produced an increase in spinal oxytocin levels. We found that stroking increased Fos immunolabeling in small oxytocin-positive cells in the paraventricular nucleus of the hypothalamus, in comparison to unstroked or handled control pups. In addition, 60 s of licking-like perineal stimulation produced a transient 89% increase in oxytocin levels in the lumbosacral spinal cord. Together, these results suggest that oxytocin afferent activity may contribute to the effects of early maternal care on the masculinization of the SNB and resultant male copulatory behavior.  相似文献   
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