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581.
Maintaining an adaptive seasonality, with life cycle events occurring at appropriate times of year and in synchrony with cohorts and ephemeral resources, is a basic ecological requisite for many cold-blooded organisms. There are many mechanisms for synchronizing developmental milestones, such as egg laying (oviposition), egg hatching, cocoon opening, and the emergence of adults. These are often irreversible, specific to particular life stages, and include diapause, an altered physiological state which can be reversed by some synchronizing environmental cue (e.g. photoperiod). However, many successful organisms display none of these mechanisms for maintaining adaptive seasonality. In this paper, we briefly review the mathematical relationship between environmental temperatures and developmental timing and discuss the consequences of viewing these models as circle maps from the cycle of yearly oviposition dates and temperatures to oviposition dates for subsequent generations. Of particular interest biologically are life cycles which are timed to complete in exactly 1 year, or univoltine cycles. Univoltinism, associated with reproductive success for many temperate species, is related to stable fixed points of the developmental circle map. Univoltine fixed points are stable and robust in broad temperature bands, but lose stability suddenly to maladaptive cycles at the edges of these bands. Adaptive seasonality may therefore break down with little warning with constantly increasing or decreasing temperature change, as in scenarios for global warming. These ideas are illustrated and explored in the context of Mountain Pine Beetle (Dendroctonus ponderosae Hopkins) occurring in the marginal thermal habitat of central Idaho's Rocky Mountains. Applications of these techniques have not been widely explored by the applied math community, but are likely to provide great insight into the response of biological systems to climate change. 相似文献
582.
The study of eye movements and oculomotor disorders has, for four decades, greatly benefitted from the application of control
theoretic concepts. This paper is an example of a complementary approach based on the theory of nonlinear dynamical systems.
Recently, a nonlinear dynamics model of the saccadic system was developed, comprising a symmetric piecewise-smooth system
of six first-order autonomous ordinary differential equations. A preliminary numerical investigation of the model revealed
that in addition to generating normal saccades, it could also simulate inaccurate saccades, and the oscillatory instability
known as congenital nystagmus (CN). By varying the parameters of the model, several types of CN oscillations were produced,
including jerk, bidirectional jerk and pendular nystagmus.
The aim of this study was to investigate the bifurcations and attractors of the model, in order to obtain a classification
of the simulated oculomotor behaviours. The application of standard stability analysis techniques, together with numerical
work, revealed that the equations have a rich bifurcation structure. In addition to Hopf, homoclinic and saddlenode bifurcations
organised by a Takens-Bogdanov point, the equations can undergo nonsmooth pitchfork bifurcations and nonsmooth gluing bifurcations.
Evidence was also found for the existence of Hopf-initiated canards.
The simulated jerk CN waveforms were found to correspond to a pair of post-canard symmetry-related limit cycles, which exist
in regions of parameter space where the equations are a slow-fast system. The slow and fast phases of the simulated oscillations
were attributed to the geometry of the corresponding slow manifold. The simulated bidirectional jerk and pendular waveforms
were attributed to a symmetry invariant limit cycle produced by the gluing of the asymmetric cycles. In contrast to control
models of the oculomotor system, the bifurcation analysis places clear restrictions on which kinds of behaviour are likely
to be associated with each other in parameter space, enabling predictions to be made regarding the possible changes in the
oscillation type that may be observed upon changing the model parameters. The analysis suggests that CN is one of a range
of oculomotor disorders associated with a pathological saccadic braking signal, and that jerk and pendular nystagmus are the
most probable oscillatory instabilities. Additionally, the transition from jerk CN to bidirectional jerk and pendular nystagmus
observed experimentally when the gaze angle or attention level is changed is attributed to a gluing bifurcation. This suggests
the possibility of manipulating the waveforms of subjects with jerk CN experimentally to produce waveforms with an extended
foveation period, thereby improving visual resolution. 相似文献
583.
A mathematical model of a segment of the gut with an enclosed pellet is constructed. The gut is represented as a thin deformable soft biological shell with the pellet modeled as a non-deformable solid. Mechanical properties of the gut wall were represented as longitudinal and circular smooth muscle layers embedded in stroma that satisfies the general type of nonlinear orthotropy. Deformations of the wall are finite. Bolus propulsion is numerically simulated by generation and propagation of an electromechanical wave along the syncytia. Pharmacological manipulation is applied to model 5-HT type 3 antagonist (Lotronex, GlaxoSmithKline) and 5-HT type 4 agonist (Zelnorm, Novartis, AB) drugs on the dynamics of bolus progression. The results lead to new quantitative insights into the complex spatio-temporal patterns of gastrointestinal transit. It is demonstrated that the reciprocal relationship in contraction of the longitudinal and circular smooth muscle syncytia is necessary to provide the "mixing" type of movements during the preparatory phase of propulsion. Strong simultaneous contractions of the both smooth muscle layers are required to expel the "mixed" pellet from the segment. The model is implemented as an interactive software system, Gut Discovery(www.aincompany.com), and accurately predicts the effects of drugs on gut motility. 相似文献
584.
Photosynthesis Research - The following question is addressed here: do healthy leaves absorb, as the spectra published over the last 50 years indicate, some 5–20% of incident radiation in the... 相似文献
585.
Steady-state analysis of structured population models 总被引:8,自引:0,他引:8
Our systematic formulation of nonlinear population models is based on the notion of the environmental condition. The defining property of the environmental condition is that individuals are independent of one another (and hence equations are linear) when this condition is prescribed (in principle as an arbitrary function of time, but when focussing on steady states we shall restrict to constant functions). The steady-state problem has two components: (i). the environmental condition should be such that the existing populations do neither grow nor decline; (ii). a feedback consistency condition relating the environmental condition to the community/population size and composition should hold. In this paper we develop, justify and analyse basic formalism under the assumption that individuals can be born in only finitely many possible states and that the environmental condition is fully characterized by finitely many numbers. The theory is illustrated by many examples. In addition to various simple toy models introduced for explanation purposes, these include a detailed elaboration of a cannibalism model and a general treatment of how genetic and physiological structure should be combined in a single model. 相似文献
586.
Environmental noise is known to sustain cycles by perturbing a deterministic approach to equilibrium that is itself oscillatory. Quasicycles produced in this way display a regular period but varied amplitude. They were proposed by Nisbet and Gurney (Nature 263 (1976) 319) as one possible explanation for population fluctuations in nature. Here, we revisit quasicyclic dynamics from the perspective of nonlinear time series analysis. Time series are generated with a predator-prey model whose prey's growth rate is driven by environmental noise. A method for the analysis of short and noisy data provides evidence for sensitivity to initial conditions, with a global Lyapunov exponent often close to zero characteristic of populations 'at the edge of chaos'. Results with methods restricted to long time series are consistent with a finite-dimensional attractor on which dynamics are sensitive to initial conditions. These results are compared with those previously obtained for quasicycles in an individual-based model with heterogeneous spatial distributions. Patterns of sensitivity to initial conditions are shown to differentiate phase-forgetting from phase-remembering quasicycles involving a periodic driver. The previously reported mode at zero of Lyapunov exponents in field and laboratory populations may reflect, in part, quasicyclic dynamics. 相似文献
587.
A straightforward and empirical regression method based on a logarithmic approximation has been developed to accurately estimate initial rates from nonlinear progress curves of enzyme reactions. The principle of this parametric approach is to use a relatively large number of observations, while averaging out random errors, to predict the curvature at time zero, which has the highest rate of change. The usual linear regression of a few initial time points lacks prediction power at time zero and therefore underestimates the true initial rate. Application of this nonlinear regression approach to enzyme reactions demonstrated satisfactory results. This approach is less subjective in choosing initial time points to be used for rate determination, and much more robust to random errors. Moreover, it is relatively easy to realize with commonly available software. 相似文献
588.
The longitudinal assessment of tumor volume is commonly used as an endpoint in small animal studies in cancer research. Groups of genetically identical mice are injected with mutant cells from clones developed with different mutations. The interest is on comparing tumor onset (i.e., the time of tumor detection) and tumor growth after onset, between mutation groups. This article proposes a class of linear and nonlinear growth models for jointly modeling tumor onset and growth in this situation. Our approach allows for interval-censored time of onset and missing-at-random dropout due to early sacrifice, which are common situations in animal research. We show that our approach has good small-sample properties for testing and is robust to some key unverifiable modeling assumptions. We illustrate this methodology with an application examining the effect of different mutations on tumorigenesis. 相似文献
589.
Nonparametric estimation in nonlinear mixed effects models 总被引:2,自引:0,他引:2
590.