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371.
Jelena Kosoric Ralph Anthony D. Williams Mark P. Hector Paul Anderson 《International journal of peptide research and therapeutics》2007,13(4):497-503
The salivary protein statherin is an inhibitor of spontaneous and secondary precipitation of hydroxyapatite (HAp). It is also
detected in enamel pellicle. The N-terminal region of statherin is involved in its adsorption onto tooth surfaces, and, calcium
binding. A peptide (StN21) was designed with a 21 amino acid sequence identical to the N-terminus of statherin. The aim was
to measure the effect of StN21 on the rate of mineral loss in a model system for dental caries and erosion using HAp subjected
to artificial carious and erosive conditions. StN21 was synthesised using Fmoc chemistry. A surface of each HAp block was
exposed to solution containing StN21 at concentrations 9.4–376 μmol L−1 (in phosphate buffer) for 24 h. Controls were HAp exposed to buffer only, and HAp exposed to lysozyme. Demineralising solution
(0.1 mol L−1 acetic acid, pH 4.5, 1.0 mmol L−1 calcium and 0.6 mmol L−1 phosphate) was circulated past the HAp blocks at 0.4 mL min-1 to mimic carious and erosive conditions. Scanning microradiography was used to measure the rate of mineral loss for demineralisation
periods of 3 weeks. The rate of mineral loss of the samples exposed to StN21 was reduced by ∼40% compared to the controls,
but no dependence on the concentration of StN21 was observed at the concentrations used. StN21 has been shown to be a potent
and stable peptide that has potential as a preventive/therapeutic agent in the treatment of enamel erosion and dental caries. 相似文献
372.
The salivary secretion of Rhodnius prolixus inhibits arachidonic acid-induced platelet aggregation and the accompanying rabbit aorta-contracting activity. Results are presented that show antagonism to thromboxane A2 on both platelet aggregation and rabbit aorta preparations. The antagonist is heat stable, non degradable by pronase, non dialysable and is sensitive to periodate oxidation.A brief review of the pharmacological properties of Rhodnius saliva is presented. It is suggested that Rhodnius prolixus developed salivary anti-haemostatic components that allows them to take a large meal in a short time. 相似文献