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排序方式: 共有282条查询结果,搜索用时 31 毫秒
101.
102.
Jennifer Morger Lars Rberg Sabine M. Hille Sanne Helsen Jan tefka Mohammad M. Al‐Sabi Christian M. O. Kapel Tapio Mappes Sandra Essbauer Rainer G. Ulrich Paola Bartolommei Alessio Mortelliti Linas Bal
iauskas Nico W. van den Brink Alice Rmy Anna Bajer Mihail Cheprakov Misa Korva Ana L. García‐Prez Roman Biek Susan Withenshaw Barbara Tschirren 《Biological journal of the Linnean Society. Linnean Society of London》2015,116(1):124-133
Parasite‐mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long‐term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll‐like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly differentiated clusters, with the three main clusters co‐occurring in at least three previously described mitochondrial lineages. This pattern indicates that the distinct TLR2 haplotype structure may precede the split of the mitochondrial lineages 0.19–0.56 Mya and suggests that haplotype clusters at this innate immune receptor are maintained over prolonged time in wild bank vole populations. 相似文献
103.
Crispin Y. Jordan Tim Connallon 《Evolution; international journal of organic evolution》2014,68(12):3555-3569
In hermaphrodites, pleiotropic genetic trade‐offs between female and male reproductive functions can lead to sexually antagonistic (SA) selection, where individual alleles have conflicting fitness effects on each sex function. Although an extensive theory of SA selection exists for dioecious species, these results have not been generalized to hermaphrodites. We develop population genetic models of SA selection in simultaneous hermaphrodites, and evaluate effects of dominance, selection on each sex function, self‐fertilization, and population size on the maintenance of polymorphism. Under obligate outcrossing, hermaphrodite model predictions converge exactly with those of dioecious populations. Self‐fertilization in hermaphrodites generates three points of divergence with dioecious theory. First, opportunities for stable polymorphism decline sharply and become less sensitive to dominance with increased selfing. Second, selfing introduces an asymmetry in the relative importance of selection through male versus female reproductive functions, expands the parameter space favorable for the evolutionary invasion of female‐beneficial alleles, and restricts invasion criteria for male‐beneficial alleles. Finally, contrary to models of unconditionally beneficial alleles, selfing decreases genetic hitchhiking effects of invading SA alleles, and should therefore decrease these population genetic signals of SA polymorphisms. We discuss implications of SA selection in hermaphrodites, including its potential role in the evolution of “selfing syndromes.” 相似文献
104.
Marijan Posavi Gregory William Gelembiuk Bret Larget Carol Eunmi Lee 《Evolution; international journal of organic evolution》2014,68(11):3166-3183
Maintenance of genetic variation at loci under selection has profound implications for adaptation under environmental change. In temporally and spatially varying habitats, non‐neutral polymorphism could be maintained by heterozygote advantage across environments (marginal overdominance), which could be greatly increased by beneficial reversal of dominance across conditions. We tested for reversal of dominance and marginal overdominance in salinity tolerance in the saltwater‐to‐freshwater invading copepod Eurytemora affinis. We compared survival of F1 offspring generated by crossing saline and freshwater inbred lines (between‐salinity F1 crosses) relative to within‐salinity F1 crosses, across three salinities. We found evidence for both beneficial reversal of dominance and marginal overdominance in salinity tolerance. In support of reversal of dominance, survival of between‐salinity F1 crosses was not different from that of freshwater F1 crosses under freshwater conditions and saltwater F1 crosses under saltwater conditions. In support of marginal overdominance, between‐salinity F1 crosses exhibited significantly higher survival across salinities relative to both freshwater and saltwater F1 crosses. Our study provides a rare empirical example of complete beneficial reversal of dominance associated with environmental change. This mechanism might be crucial for maintaining genetic variation in salinity tolerance in E. affinis populations, allowing rapid adaptation to salinity changes during habitat invasions. 相似文献
105.
The iPecs™ load cell is a lightweight, six-degree-of-freedom force transducer designed to fit easily into an endoskeletal prosthesis via a universal mounting interface. Unlike earlier tethered systems, it is capable of wireless data transmission and on-board memory storage, which facilitate its use in both clinical and real-world settings. To date, however, the validity of the iPecs™ load cell has not been rigorously established, particularly for loading conditions that represent typical prosthesis use. The aim of this study was to assess the accuracy of an iPecs™ load cell during in situ human subject testing by cross-validating its force and moment measurements with those of a typical gait analysis laboratory. Specifically, the gait mechanics of a single person with transtibial amputation were simultaneously measured using an iPecs™ load cell, multiple floor-mounted force platforms, and a three-dimensional motion capture system. Overall, the forces and moments measured by the iPecs™ were highly correlated with those measured by the gait analysis laboratory (r>0.86) and RMSEs were less than 3.4% and 5.2% full scale output across all force and moment channels, respectively. Despite this favorable comparison, however, the results of a sensitivity analysis suggest that care should be taken to accurately identify the axes and instrumentation center of the load cell in situations where iPecs™ data will be interpreted in a coordinate system other than its own (e.g., inverse dynamics analysis). 相似文献
106.
The major histocompatibility complex (MHC) is a dynamic genetic region with an essential role in the adaptive immunity of jawed vertebrates. The MHC polymorphism is affected by many processes such as birth-and- death evolution, gene conversion, and concerted evolution. Studies investigating the evolution of MHC class I genes have been biased toward a few particular taxa and model species. However, the investigation of this region in nonavian reptiles is still in its infancy. We present the first characterization of MHC class I genes in a species from the family Lacertidae. We assessed genetic diversity and a role of selection in shaping the diversity of MHC class I exon 4 among 37 individuals of Eremias multiocellata from a population in Lanzhou, China. We generated 67 distinct DNA sequences using cloning and sequencing methods, and identified 36 putative functional variants as well as two putative pseudogene-variants. We found the number of variants within an individual varying between two and seven, indicating that there are at least four MHC class I loci in this species. Gene duplication plays a role in increasing copy numbers of MHC genes and allelic diversity in this species. The class I exon 4 sequences are characteristic of low nucleotide diversity. No signal of recombination is detected, but purifying selection is detected in β2-microglobulin interaction sites and some other silent sites outside of the function-constraint regions. Certain identical alleles are shared by Eremias multiocellata and E. przewalskii and E. brenchleyi, suggesting trans-species polymorphism. The data are compatible with a birth-and-death model of evolution. 相似文献
107.
Daniel Castillo Javier Raya-Gonzlez Filipe Manuel Clemente Daniele Conte Alejandro Rodríguez-Fernndez 《Biology of sport / Institute of Sport》2021,38(3):483
This study aimed to analyse the influence of different contextual factors (i.e., defensive style and game outcome) on basketball players’ external load during games-based drills using ultrawideband (UWB) technology. Fourteen male professional basketball players belonging to an elite reserve Spanish club (ACB) participated in this study. The games-based drills consisted of one bout of 10 min played 5vs5 in which players were instructed to use man-to-man defence (MMD) and/or zone defence (ZD). In addition, the final game outcome (i.e., winning or losing) of the game-based drill was registered. External load variables per minute were recorded: total distance covered, distance covered in different speed zones, distance covered while accelerating and decelerating, maximum speed, steps, jumps and player load. A two-way ANOVA with the Tukey post hoc test was used to assess the impact of defensive style and final game outcome and the interaction of both factors on the external load encountered by basketball players. No meaningful differences (unclear) were found in the external loads between playing with MMD and with ZD and between winning and losing teams except for greater distance at high-speed running (18.0–24.0 km·h-1) in winning teams (p < 0.05, ES = 0.68, moderate). A significant interaction between defensive style and final game outcome was found for high decelerations (> -2 m·s-2) (p = 0.041; ES = 0.70) and jumps (p = 0.037; ES = 0.68). These results could potentially help coaching staff in prescribing an appropriate workload during basketball-specific game-based drills, and ultimately enhance the match performance. 相似文献
108.
Åsa Hasselquist Langefors 《Environmental Biology of Fishes》2005,74(3-4):297-308
Synopsis I combined neutral microsatellite markers with the major histocompatibility complex (MHC) class IIB to study genetic differentiation
and colonization history in Atlantic salmon, Salmo salar, in the Baltic Sea and in the north-eastern Atlantic. Baltic salmon populations have lower levels of microsatellite genetic
variation, in terms of heterozygosity and allelic richness than Atlantic populations, confirming earlier findings with other
genetic markers, suggesting that the Baltic Sea populations have been exposed to genetic bottlenecks, most likely at a founding
event. On the other hand, the level of MHC variation was similar in the Baltic and in the north-eastern Atlantic, indicating
that positive balancing selection has increased the level of MHC-variation. Both microsatellite and MHC class IIB genetic
variation give strong support to the hypothesis that the Baltic salmon are of a biphyletic origin, the southern population
in this study is strongly differentiated from both the northern Baltic salmon populations and from the north-eastern Atlantic
populations. Salmon may have colonized the northern Baltic Sea either from the south, via the so called “N?rke strait” or
from the north, via a proposed historical connection between the White Sea and the northern Baltic. At microsatellites, no
significant isolation-by distance was found at either colonization route. At the MHC, populations were significantly isolated
by distance when assuming that colonization occurred via the “N?rke strait”. 相似文献
109.
Extensive polymorphism and geographical variation at a positively selected MHC class II B gene of the lesser kestrel (Falco naumanni) 总被引:1,自引:0,他引:1
Understanding the selective forces that shape genetic variation in natural populations remains a high priority in evolutionary biology. Genes at the major histocompatibility complex (MHC) have become excellent models for the investigation of adaptive variation and natural selection because of their crucial role in fighting off pathogens. Here we present one of the first data sets examining patterns of MHC variation in wild populations of a bird of prey, the lesser kestrel, Falco naumanni . We report extensive polymorphism at the second exon of a putatively functional MHC class II gene, Fana- DAB*1. Overall, 103 alleles were isolated from 121 individuals sampled from Spain to Kazakhstan. Bayesian inference of diversifying selection suggests that several amino acid sites may have experienced strong positive selection (ω = 4.02 per codon). The analysis also suggests a prominent role of recombination in generating and maintaining MHC diversity (ρ = 4 Nc = 0.389 per codon, θ = 0.017 per codon). Both the Fana -DAB*1 locus and a set of eight polymorphic microsatellite markers revealed an isolation-by-distance pattern across the Western Palaearctic ( r = 0.67; P = 0.01 and r = 0.50; P = 0.04, respectively). Nonetheless, geographical variation at the MHC contrasts with relatively uniform distributions in the frequencies of microsatellite alleles. In addition, we found lower fixation rates in the MHC than those predicted by genetic drift after controlling for neutral mitochondrial sequences. Our results therefore underscore the role of balancing selection as well as spatial variations in parasite-mediated selection regimes in shaping MHC diversity when gene flow is limited. 相似文献
110.
Natural selection is expected to leave an imprint on the neutral polymorphisms at the adjacent genomic regions of a selected gene. While directional selection tends to reduce within-population genetic diversity and increase among-population differentiation, the reverse is expected under balancing selection. To identify targets of natural selection in the three-spined stickleback ( Gasterosteus aculeatus ) genome, 103 microsatellite and two indel markers including expressed sequence tags (EST) and quantitative trait loci (QTL)-associated loci, were genotyped in four freshwater and three marine populations. The results indicated that a high proportion of loci (14.7%) might be affected by balancing selection and a lower proportion (2.8%) by directional selection. The strongest signatures of directional selection were detected in a microsatellite locus and two indel markers located in the intronic regions of the Eda-gene coding for the number of lateral plates. Yet, other microsatellite loci previously found to be informative in QTL-mapping studies revealed no signatures of selection. Two novel microsatellite loci ( Stn12 and Stn90 ) located in chromosomes I and VIII, respectively, showed signals of directional selection and might be linked to genomic regions containing gene(s) important for adaptive divergence. Although the coverage of the total genomic content was relatively low, the predominance of balancing selection signals is in agreement with the contention that balancing, rather than directional selection is the predominant mode of selection in the wild. 相似文献