中国四川荞麦属（蓼科）一新变种——翅果密毛野荞麦

描述了蓼科一新变种——翅果密毛野荞麦[Fagopyrum densovillosum J. L. Liu var.pterocarpum J. L. Liuet X.J.Li],并绘制了形态图。新变种瘦果较大,长2.5～3mm,宽(2～)2.5～3mm,果棱上具翅,翅宽0.5～1mm,雄蕊长于雌蕊,从而区别于原变种密毛野荞麦(Fagopyrum densovillosumJ.L.Liu);另外,新变种全株密被短毛或长毛,茎枝较粗壮,红褐色,节较密集,叶片在表面具细皱纹和小泡状突起,雄蕊长于雌蕊,而又不同于齿翅野荞麦[Fagopyrum gracilipes(Hemsl.)Damm.et Diels var. odontopterum(Gross)Sam]。     

中国栘木衣属（Docynia Dcne.）一新种——长爪栘木衣

报道了栘木衣属一新种,长爪栘木衣(Docynia longisunguis Q.Luo et J.L.Liu)。该新种与栘木衣(Docynia indica(Will.) Dcne.)和云南栘木衣(Docynia delavayi (Franch.)Schneid.)相似,但以花较大,直径3.5~4 cm,花瓣长20～25 mm,宽12～16 mm,基部具长爪,长5～9 mm,雄蕊46～53;子房5～6（7）,花柱5～6（7）;果径3～4.5 cm,而与它们相区别。     

推拿联合简易六字诀功法治疗抽动障碍患者的疗效及安全性分析

摘要 目的：探究推拿联合简易六字诀功法治疗抽动障碍患者的疗效及安全性分析。方法：选择2021年3月至2022年1月于上海中医药大学附属岳阳中西医结合医院就诊于推拿科,并通过病史询问、量表评估被确诊为抽动障碍的患者。本研究随机分为对照组（n=27）及联合组（n=31）2组,对照组进行单纯推拿治疗,联合组进行推拿联合六字诀功法治疗。根据耶鲁综合抽动严重程度量表对患儿治疗前后的运动性抽动、发声性抽动以及社会行为影响作出评估,根据尼莫地平法计算患儿治疗前后疗效指数,统计患儿治疗的不良事件。结果：（1）两组患儿一般临床资料对比无差异（P>0.05）。（2）联合组总有效率高于对照组（P<0.05）。（3）治疗前联合组与对照组发声性抽动评分、缺损评分无差异,治疗后联合组发声性抽动评分、缺损评分明显高于对照组,两组治疗后均明显低于治疗前（P<0.05）。（4）治疗前后联合组与对照组YGTSS总分、运动性抽动评分无差异,两组治疗后YGTSS总分与运动性抽动评分均明显低于治疗前,且联合组低于对照组（P<0.05）。结论：推拿和简易六字诀功法对抽动障碍患儿都有显著的治疗效果,且效果无差异,与单纯推拿相比,推拿联合简易六字诀功法更能降低患儿的缺损评分,减少抽动对患儿自尊、家庭生活、社交和学习的负面影响,值得临床借鉴。     

Pulmonary Sarcomatoid Carcinoma with ALK Rearrangement: Frequency,Clinical-Pathologic Characteristics,and Response to ALK Inhibitor

PURPOSE: The incidence of anaplastic lymphoma kinase (ALK) rearrangement in pulmonary sarcomatoid carcinoma (PSC) is controversial. In this study, we aimed to reveal the reliable frequency and the clinical-pathologic characteristics of pulmonary sarcomatoid carcinoma (PSC) with ALK rearrangement in Chinese population, and to provide insight into the translatability of anti-ALK treatment in this treatment-refractory disease. METHODS: Immunohistochemistry (IHC) using a Ventana anti-ALK (D5F3) rabbit monoclonal antibody was performed in 141 PSC specimens collected from multiple medical centers. IHC-positive cases were then confirmed using ALK fluorescent in situ hybridization (FISH). The incidence rates and clinical-pathologic characteristics of ALK-rearranged PSC were then analyzed. Response to ALK inhibitor crizotinib in a patient with ALK-rearranged PSC was evaluated according to the response evaluation criteria for solid tumors (RECIST) version 1.1. RESULTS: Five of 141 (3.5%) of PSCs showed ALK rearrangement-positive by IHC and then were confirmed by FISH. Two were carcinosarcomas and the other three were pulmonary pleomorphic carcinoma (PPC). Strong positive ALK rearrangement was observed in both the epithelioid and sarcomatoid components. The median age of ALK-positive patients was younger than that of ALK-negative patients. PSCs in never-smokers were more likely to harbor ALK rearrangement than those in former or current smokers (P < .05). A 40-year-old woman diagnosed with ALK-rearranged PPC experienced a partial response (?32%) to the ALK inhibitor crizotinib. CONCLUSIONS: The incidence rates of ALK rearrangement in PSC in the Chinese population are similar to those of other subtypes of NSCLC. PSCs in younger never-smokers are more often to harbor ALK rearrangement. ALK inhibitors may serve as an effective treatment for ALK-rearranged PSC.     

微生物学“六化”教学理念和管理模式的构建及实施

针对微生物教学中存在的问题进行一系列改革,总结出了"六化"教学理念和管理方式:教师团队层次化,兴趣引导文学化,微生物史纵横化,知识讲解形象化,实验选题生活化,考核方式多元化。教学改革涉及教学方法、教学内容以及考核方式等多方面,取得显著效果。学生不仅在专业知识的学习上取得进步,而且综合素质得到了全面提升。     

Effects of alloxan-diabetes on the sodium-potassium adenosine triphosphatase enzyme system in dog hearts

The effects of alloxan-diabetes on the partial reaction of (Na⁺+K⁺)-ATPase, K⁺-activated para-nitrophenylphosphatase, and on ouabain binding were studied in isolated adult dog heart myocytes. The Km of K⁺-activated para-nitrophenylphosphatase for K⁺ activation was increased from 2.5 to 7.7 mM with no change in Vmax. The Scatchard plots for ouabain binding between control and diabetic animals were indistinguishable. These results indicate that in acute diabetes induced by alloxan, the number of Na⁺-K⁺ pumping sites in the heart is not altered but the affinity of the system for K⁺ is decreased. It is suggested that the decrease in K⁺ affinity of the (Na⁺+K⁺)-ATPase enzyme system is at least in part responsible for the altered K⁺ homeostasis in the diabetic state.