Revision of the good fortune scale: A new tool for the study of "big dreams."

This article proposes a revision of the good fortune (GF) scale of the Hall and Van de Castle (HVDC; 1966) content analysis scoring system. In place of the original one-point GF scale, this proposed revision offers a 6-point scale that conceptually matches the HVDC system's 6 types of misfortune. The GF scale is then applied to the 1000 HVDC norm dreams to generate a new estimation of the average frequency of the 6 types of good fortune. These findings are discussed in relation to the study of highly memorable and impactful dreams, what C. G. Jung (1948/1979) called "big dreams." The new GF scale strengthens the ability of the HVDC system to contribute to the interdisciplinary study of those rare but unusually significant types of dreams. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

‘To bring out the best that is in their blood’: Race,reform, and civilization in the journal of race development (1910–1919)

The Journal of Race Development [JRD], published out of Clark University in the United States between 1910 and 1919, aimed, in its founder's words, “to present … the important facts which bear upon race progress, and the different theories as to the methods by which developed peoples may most effectively aid the progress of the undeveloped”. Its basic premise was that scientific knowledge could harness racial or civilizational “evolution” and turn it into “development”. This article examines that project, the conceptual apparatus that the JRD's writers and editors brought to bear on it, and how racial ideas informed their conceptions of development and progressive social change through elite scientific and political intervention. Central to this project was an organic notion of “civilization” in which “nature” and “culture” did not so much overlap as flow seamlessly one into the other.     

生物驻极体载流子特性分析

对猪骨这一生物驻极体中的电荷载流子的特性进行了一些分析.结果表明.在正常状态下.动物骨骼内部的导电载流子主要来自于其胶原纤维和基质细胞中的水分子.这时用范畴堡尔法测得其霍尔系数为负值.具有N型半导体的一些特征.若对高温干燥处理后的猪骨进行测量.则观察到其霍尔系数的反向突变,显示出P型半导体的导电性.这一转变被解释为水分子的丧失使样品中的正离子导电从次要地位转变为主要地位,加热时样品中水分子的迁移过程会在短接的外电路中形成一方向恒定的负电流峰,对电流峰的计算表明,猪骨中负电荷的激活能为0.86eV左右.     

A Preliminary Proteomic Investigation of Circulating Exosomes and Discovery of Biomarkers Associated with the Progression of Osteosarcoma in a Clinical Model of Spontaneous Disease

Circulating cancer exosomes are microvesicles which originate from malignant cells and other organs influenced by the disease and can be found in blood. The exosomal proteomic cargo can often be traced to the cells from which they originated, reflecting the physiological status of these cells. The similarities between cancer exosomes and the tumor cells they originate from exhibit the potential of these vesicles as an invaluable target for liquid biopsies. Exosomes were isolated from the serum of eight osteosarcoma-bearing dogs, five healthy dogs, and five dogs with traumatic fractures. We also characterized exosomes which were collected longitudinally from patients with osteosarcoma prior and 2 weeks after amputation, and eventually upon detection of lung metastasis. Exosomal proteins fraction were analyzed by label-free mass spectrometry proteomics and were validated with immunoblots of selected proteins. Ten exosomal proteins were found that collectively discriminate serum of osteosarcoma patients from serum healthy or fractured dogs with an accuracy of 85%. Additionally, serum from different disease stages could be distinguished with an accuracy of 77% based on exosomal proteomic composition. The most discriminating protein changes for both sample group comparisons were related to complement regulation, suggesting an immune evasion mechanism in early stages of osteosarcoma as well as in advanced disease.     

A radiometric assay of pyridoxamine (pyridoxine) 5′-phosphate oxidase

A radiometric assay for pyridoxamine 5′-phosphate oxidase (pyridoxamine (pyridoxine) 5′-phosphate:O₂ oxidoreductase (deaminating), EC 1.4.3.5) has been developed utilizing N-(5′-phosphopyridoxyl)[³H]tryptamine. This assay is more sensitive than previously used colorimetric and fluorescent assays for this oxidase and furthermore is applicable to erythrocytes. Tritiated substrate is incubated with an enzyme sample in the presence of excess unlabeled truptamine and the radiolabeled tryptamine product is extracted into toluene and quantitated by liquid scintillation counting.     

Nonspecific entry of thoracic duct immunoblasts into intradermal foci of antigens

Lymph borne immunoblasts were obtained by collecting thoracic duct lymph from inbred rats 3–5 days after either killed C. parvum, B. abortus or B.C.G. organisms had been injected subcutaneously into the hindquarter regions to stimulate the caudal lymph nodes. By incubating the lymph cells with a radioactive precursor of DNA, 5-iodo-2-deoxyuridine-¹²⁵I, the immunoblasts became labelled but the small lymphocytes did not. The labelled cells were washed and injected intravenously into syngeneic recipients which had had intradermal injections of various antigens at various previous times. The entry of labelled cells into these injection sites was monitored by counting the radioactivity that they contained up to 24 hr later.It was found that the accumulation of radioactivity in the skin lesions was maximal 12 hr after the donor cells had been injected, but the immunological specificity of the donor immunoblasts did not affect significantly the extent to which they entered lesions which contained the same or unrelated antigens. It was found also that the sites of intradermal injections of B.C.G. or C. parvum always attracted more immunoblasts than sites containing other antigens; this was a non-specific effect, thought to be related to the adjuvant properties of these organisms.     

Hypothesis: a model for generalised autoimmunity

A detailed mechanism for the development of generalised autoimmunity is suggested, and the significance of the association between autoimmunity and leukemia is discussed.     

Natural cytotoxicity in rats: Strain distribution and genetics

The term natural cytotoxicity (NC) describes a phenomenon in rats whereby significant numbers of intravenously injected ⁵¹Cr-labeled lymph node cells are rapidly destroyed by unsensitized allogeneic hosts. Cell death is reflected in a decreased accumulation of labeled cells in the host lymph nodes, with a corresponding increase in the label excreted by the kidney. Natural cytotoxicity has been studied in 95 allogeneic donor-host combinations among inbred rats and in a segregating population of F1 backcross animals. On the basis of lymphocyte distribution patterns, the individual donor-host combinations have been categorized as exhibiting high NC (13 strain combinations), intermediate NC (63 strain combinations), or low NC (19 strain combinations). Analysis of the segregating F1 backcross population showed NC to be controlled by at least two independently segregating genes, one of which was linked to the MHC, and the other of which was possibly, but by no means certainly, X linked. No linkage was demonstrated with respect to coat color loci (C, A, H) or to kappa chain allotype (RI-1). Natural cytotoxicity appears to belong to a group of several phenomena characterized by the rapid destruction of allogeneic cells by apparently unsensitized hosts.