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71.
Intra-specific variation in social organization of gorillas: implications for their social evolution
We analysed intra-specific variation in the social organization of gorillas and ecological and social factors influencing them, based on recent data on diet, day journey length, home range size, group size and proportion of multi-male groups in three subspecies [western lowland gorillas (WLG); eastern lowland gorillas (ELG); mountain gorillas (MG)]. Median group size was similar across subspecies and across habitats, but the extraordinarily large group including >30 gorillas was only found in habitat with dense terrestrial herbaceous vegetation. Within-group competition may determine the upper limit of group size in frugivorous WLGs and ELGs in lowland habitats with scarce undergrowth. A frugivorous diet may be a causal factor of subgrouping in multi-male groups of WLGs and ELGs, while a folivorous diet may prevent subgrouping in multi-male groups of MGs. Social factors, rather than ecological factors, may play an important role in the formation of multi-male groups and their cohesiveness in MGs. High gregariousness of female gorillas and their prolonged association with a protector male are explained by their vulnerability to both infanticide (MGs) and predators (ELGs). Comparison of long-term changes in group composition and individual movements between ELGs in Kahuzi and MGs in the Virungas suggest that the occurrence of infanticide may promote kin-male association within a group. Threat of infanticide may stimulate MG females to transfer into multi-male groups to seek reliable protection and maturing MG males to stay in their natal groups after maturity. By contrast, the absence of infanticide may facilitate ELG females to associate with infants and other females at transfer and ELG males to establish large groups in a short period by taking females from their natal groups, by luring females from neighbouring groups, or by takeover of a widow group after the death of its leading male. These conditions may prevent ELG and WLG maturing males from remaining to reproduce in their natal groups and possibly result in a rare occurrence of multi-male groups in their habitats. Similar reproductive features of MG and ELG females suggest both female strategies have been adaptive in their evolutionary history. 相似文献
72.
Jeff Kirby 《Biology & philosophy》2003,18(5):683-694
Abstract. Scientists have long puzzled over how homosexual orientation has evolved, given the assumed low relative fitness of homosexual individuals compared to heterosexual individuals. A number of theoretical models for the evolution of homosexuality have been postulated including balance polymorphism, "Fertile females", hypervariability of DNA sequences, kin selection, and "parental manipulation". In this paper, I propose a new group-selection model for the evolution of homosexuality which offers two advantages over existing models: (1) its non-assumption of genetic determinism, and (2) its lack of dependency on an inefficient altruism relation and family dynamics theory. 相似文献
73.
74.
Eyal O Jadoun J Bitler A Skutelski E Sela S 《FEMS immunology and medical microbiology》2003,38(3):205-213
Streptococcus pyogenes utilizes multiple mechanisms for adherence to and internalization by epithelial cells. One of the molecules suggested of being involved in adherence and internalization is the M protein. Although strains of the M3 serotype form the second largest group isolated from patients with severe invasive diseases and fatal infections, not much information is known regarding the interactions of M3 protein with mammalian cells. In this study we have constructed an emm3 mutant of an invasive M3 serotype (SP268), and demonstrated that the M3 protein is involved in both adherence to and internalization by HEp-2 cells. Fibronectin promoted both adherence and internalization of SP268 in an M3-independent pathway. Utilizing speB and speB/emm3 double mutants, it was found that M3 protein is not essential for the maturation of SpeB, as was reported for the M1 protein. Increased internalization efficiency observed in both the speB and emm3/speB mutants suggested that inhibition of S. pyogenes internalization by SpeB is not related to the presence of an intact M3 protein. Thus, other proteins in SP268, which serve as targets for SpeB activity, have a prominent role in the internalization process. 相似文献
75.
Ossowska K Pietraszek M Wardas J Nowak G Zajaczkowski W Wolfarth S Pilc A 《Amino acids》2000,19(1):87-94
Summary. It has recently been postulated that disturbances in glutamatergic neurotransmission may contribute to the pathophysiology
of schizophrenia. Therefore the aim of the present study was to evaluate the role of glutamate NMDA and group II metabotropic
receptors in the antipsychotic drug action. To this aim the influence of some well-known neuroleptics on cortical NMDA receptors
was examined. Furthermore, their behavioral effects were compared with those of the novel agonist of group II glutamate metabotropic
receptors, LY 354740, in some animal models of schizophrenic deficits. We found that long-term administration of the typical
neuroleptic haloperidol and the atypical one clozapine increased the number of NMDA receptors labelled with [3H]CGP 39653 in different cortical areas. Long-, but not short-term, treatment with haloperidol and raclopride diminished the
deficit of prepulse inhibition produced by phencyclidine, which is a model of sensorimotor gating deficit in schizophrenia.
In contrast, neither short- nor long-term treatment with clozapine influenced the phencyclidine effect in that model. Acute
treatment with LY 354740 reversed neither (1) the deficit of prepulse inhibition produced by phencyclidine or apomorphine,
nor (2) the impairment in a delayed alternation task induced by MK-801, which is commonly used to model the frontal lobe deficits
associated with schizophrenia. The present study suggests that an increase in the density of cortical NMDA receptors may be
important to a longterm neuroleptic therapy. Conversely, the results do not support the role of group II metabotropic glutamate
receptors in the antipsychotic drug action.
Received August 31, 1999 Accepted September 20, 1999 相似文献
76.
In DNA library screening, blood testing, and monoclonal antibody generation, significant savings in the number of assays can be realized by employing group sampling. Practical considerations often limit the number of stages of group testing that can be performed. We address situations in which only two stages of testing are used. We define efficiency to be the expected number of positives isolated per assay performed and assume gold-standard tests with unit sensitivity and specificity. Although practical tests never are golden, polymerase chain reaction (PCR) methods provide procedures for screening recombinant libraries that are strongly selective yet retain high sensitivity even when samples are pooled. Also, results for gold-standard tests serve as bounds on the performance of practical testing procedures. First we derive formulas for the efficiency of certain extensions of the popular rows-and-columns technique. Then we derive an upper bound on the efficiency of any two-stage strategy that lies well below the classical upper bound for situations with no constraint on the number of stages. This establishes that a restriction to only two stages necessitates performing many more assays than efficient multistage procedures need. Next, we specialize the bound to cases in which each item belonging only to pools that tested positive in stage 1 must be tested individually in stage 2. The specialized bound for such positive procedures is tight because we show that an appropriate multidimensional extension of the rows-and-columns technique achieves it. We also show that two-stage positive procedures in which the stage-1 groups are selected at random perform suboptimally, thereby establishing that efficient tests must be structured carefully. 相似文献
77.
西双版纳部分地区鸟类多样性初步考察 总被引:9,自引:2,他引:7
1992年12月,1993年11月及1994年4~5月,对西双版纳自然保护区内外的数个工作点进行了鸟类物种多样性的调查,共记录鸟类190种。分析表明雀形目鸟类物种多样性状态尚佳,而非雀形目鸟类类群(科种)多样性及物种多样性状态均恶化趋势,保护区内鸟类物种多样性状态明显较好,傣族墓葬地之龙山因依傍村落,农田及其他多种生境而具有相当丰富的鸟类物种多样性,是保护鸟类物种多样性不可忽视的一个方面,研究表明 相似文献
78.
《Palaeoworld》2015,24(3):251-262
The Paleo-Mesoproterozoic Ruyang Group of North China hosts early eukaryotic fossils such as Dictyosphaera, Shuiyousphaeridium, and Valeria, and thus offers valuable insights into the early evolution of single-celled eukaryotic life. In this paper, we report several additional forms of organic-walled microfossils from the Ruyang Group, including Plicatidium latum, Spiromorpha sp., and an unnamed form. V. lophostriata from the Ruyang Group is investigated using transmitted light microscopy, scanning electron microscopy, transmission electron microscopy, and biomechanical analysis. V. lophostriata is reconstructed as a spherical vesicle with two hemispherical halves bearing concentric striations resembling latitudinal circles. The formation of striations could be explained using the Belousov-Zhabotinsky reaction model or the Turing reaction-diffusion model. A biomechanical analysis using the thin-walled spherical pressure vessel model suggests that the concentric striations of V. lophostriata may have functioned as a mechanism to guide biologically programmed excystment through medial split. Our analysis provides essential paleontological data to better understand the functional biology and life cycles of early eukaryotes such as Valeria. 相似文献
79.
Abhishek Kumar Sandeep J. Sarde Anita Bhandari 《Biochemical and biophysical research communications》2014
Angiotensinogen (AGT) belongs to the serpin superfamily. It acts as the unique substrate of all angiotensin peptides, which generates a spectrum of angiotensin peptides in the renin-angiotensin system and regulates hypertension. This serpin belongs to the multiple member group V2 of the intron encoded vertebrate serpin classification. Despite huge advancements in the understanding of angiotensinogen based on biochemical properties and its roles in the RAS, phylogenetic history of AGT remains forgotten. To date, there is no comprehensive study illustrating the phylogenetic history of AGT. Herein, we investigated phylogenetic traits of AGT gene across vertebrates. Gene structures of AGT gene from selected ray-finned fishes varied in exon I and II with insertions of two novel introns in the core domain for ray-finned fishes at the position 77c and 233c. We that found AGT loci is conserved from lampreys to human and estimated to be older than 500 MY. By comparing AGT protein in 57 vertebrate genomes, we illustrated that the reactive center loop (RCL) of AGT protein became from inhibitory (in lampreys, GTEAKAETVVGIMPI†SMPPT) to non-inhibitory (in human, EREPTESTQQLNKPE†VLEVT) during period of 500 MY. We identified 690 AGT variants by analysis of 1092 human genomes with top three variation classes belongs to SNPs (89.7%), somatic SNVs (5.2%) and deletion (2.9%). There are 32 key residues out of 121 missense variants, which are deleterious for AGT protein, computed by combination of SIFT and PolyPhen V2 methods. These results may have clinical implications for understanding hypertension. 相似文献
80.
Abhishek Kumar Anita Bhandari Sandeep J. Sarde Chandan Goswami 《Biochemical and biophysical research communications》2014
C1 inhibitor (C1IN) is a multi-facet serine protease inhibitor in the plasma cascades, inhibiting several proteases, notably, regulates both complement and contact system activation. Despite huge advancements in the understanding of C1IN based on biochemical properties and its roles in the plasma cascades, the phylogenetic history of C1IN remains uncharacterized. To date, there is no comprehensive study illustrating the phylogenetic history of C1IN. Herein, we explored phylogenetic history of C1IN gene in vertebrates. Fishes have C1IN with two immunoglobulin like domains attached in the N-terminal region. The RCL regions of CIIN from fishes and tetrapod genomes have variations at the positions P2 and P1′. Gene structures of C1IN gene from selected ray-finned fishes varied in the Ig domain region with creation of novel intron splitting exon Im2 into Im2a and Im2b. This intron is limited to ray-finned fishes with genome size reduced below 1 Gb. Hence, we suggest that genome compaction and associated double-strand break repairs are behind this intron gain. This study reveals the evolutionary history of C1IN and confirmed that this gene remains the same locus for ∼450 MY in 52 vertebrates analysed, but it is not found in frogs and lampreys. 相似文献