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31.
Daniel R. Vlock Beth Arnold Jeannette Humpierres Donald R. Schwartz Shan R. Baker Charles J. Krause Neil Swanson Thomas E. Carey 《Cancer immunology, immunotherapy : CII》1992,34(5):329-336
Summary In previous studies we evaluated the incidence and specificity of autologous antibody reactivity against squamous cell carcinoma of the head and neck (SCCHN). We were able to demonstrate that autologous antibody reactivity is present in native sera but was usually of too low a titer to allow further analysis. Dissociation of immune complexes by acidification and ultrafiltration of serum augmented autologous antibody reactivity in nine out of nine autologous systems tested. Native antibody and antibody derived from immune complexes produced by the host and reactive with autologous tumor cells may be directed against physiologically relevant antigens. Therefore, correlations of antibody titers with clinical course may provide insight into the nature of the host response to cancer. In the present analysis, serological studies of six patients with SCCHN were performed with serum samples obtained over many months. Results of serial serological assays were correlated to tumor progression and clinical course. Fluctuations in autologous antibody reactivity were noted over time. In four cases, rises in autologous antibody titers preceded the clinical diagnosis of recurrence by several months. Drops in autologous antibody reactivity were noted in two cases following surgery or radiation therapy. In two cases of long-term survivors, no correlation between antibody reactivity and clinical course was noted. Specificity analysis of the six autologous systems demonstrated reactivity against autologous and allogeneic SCCHN as well as melanoma cell lines. These sera did not react with glioma, neuroblastoma, renal cell, breast, bladder and colon carcinoma cell lines nor with fetal calf serum, pooled lymphocytes, red blood cells and platelets. Autologous serial serological studies may provide a means by which to evaluate the host/tumor relationship in patients with SCCHN. 相似文献
32.
Franz Uiblein 《Environmental Biology of Fishes》1992,33(3):311-316
Synopsis Experimental data on snapping behavior of laboratory reared zährte, Vimba elongata, indicate that this species chooses between different food searching methods. If visibility is good, mainly directed snaps are employed for immediate food location. However, under conditions of reduced visibility undirected snapping and sampling methods are adopted. In the field, zährte may use sampling to acquire foraging benefits from stochastically distributed, hidden resources, like sediment dwelling prey. In the experiments this species continued to sample the bottom even in situations without any chance of prey detection. It is therefore concluded that zährte's searching decisions, apart from incorporating external information on prey occurrence, are controlled by internal expectations of long term benefits derived from sampling. 相似文献
33.
The oviposition behavior of single females of Drosophila melanogasterwas studied in population cages over 24 h. Each female shows a different behavior, but they can be arbitrarily separated into those which concentrate their egg laying in only one tube and those which spread it over more than two tubes. A comparison is made between females extracted from the Valdivian population and flies from lines selected for high and low aggregation. When one-tube females were grouped and compared with more-than-one-tube females, the aggregation indices between these groups were significantly different. 相似文献
34.
Summary Two laboratory experiments were conducted to examine the ovipositional preferences of the egg parasitoidOoencyrtus nezarae Ishii (Hymenoptera: Encyrtidae) for parasitized and unparasitizedMegacopta punctatissimum Montandon (Hemiptera: Plataspidae). Females that had never oviposited or that had not oviposite for 3 days preferred recently parasitized hosts more than unparasitized hosts. The preference for recently parasitized hosts appeared to be mediated by the punctures in already parasitized hosts made by the ovipositor of the first female. Survival of the parasitoid progeny was lower in recently parasitized hosts than in unparasitized hosts. However, handling time of parasitized hosts was extremely short relative to that of unparasitized hosts, because the superparasitizing female could use the punctures made by the previous females. It is concluded that the females preferred the parasitized hosts over unparasitized hosts because the benefit of saving time and energy for drilling was more than the cost of progeny survival. 相似文献
35.
Summary Host selection by phytophagous insects is generally thought to be based on chemical or nutritional characteristics of the host. This is especially true for monophagous insects. However, many other factors may influence host choice. The present study examines host selection by Drosophila magnaquinaria, whose sole host is the yellow skunk cabbage, Lysichitum americanum. Utilization of skunk cabbage was tested relative to a set of alternative hosts. In the pre-alighting stage of host selection, skunk cabbage was found to be less attractive than tomato, cucumber, and commercial mushrooms. In pairwise oviposition tests, there were no differences among hosts. There were no differences in larval survivorship among skunk cabbage, tomato, cucumber, or Ramaria, and larvae developed into pupae earlier on tomato than on skunk cabbage. These results indicate that this monophagy is not based on characteristics of the host. We suggest that habitat selection is the more important factor in determining the association between D. magnaquinaria and skunk cabbage. 相似文献
36.
Influence of aphid size,age and behaviour on host choice by the parasitoid wasp Ephedrus californicus: a test of host-size models 总被引:1,自引:0,他引:1
Summary When host quality varies, parasitoid wasps are expected to oviposit selectively in high-quality hosts. We tested the assumption underlying host-size models that, for solitary species of wasps, quality is based on host size. Using Ephedrus californicus, a solitary endoparasitoid of the pea aphid, we evaluated the influence of aphid size (= mass), age and defensive behaviours on host selection. Experienced parasitoid females were given a choice among three classes of 5-day-old apterous nymphs: small aphids that had been starved daily for 4 h (S4) and 6 h (S6) respectively, and large aphids permitted to feed (F) normally. Wasps attacked more, and laid more eggs in, small than large aphids (S6>S4>F). This rank-order for attack did not change when females could choose among aphids of the same size that differed in age; however, wasps oviposited in all attacked aphids with equal probability. Host size did not influence parasitoid attack rates when aphids were anaesthetized so that they could not escape or defend themselves. As predicted by host-size models, wasp size increased with host size (F>S4; S6), but large wasps required longer to complete development than their smaller counterparts (S4Host choice in E. californicus reflects a trade-off between maximization of fitness gains per egg and the economics of search-time allocation. Because large aphids are more likely to escape parasitization, a wasp must balance her potential gain in fitness by ovipositinng in a high-quality (large) aphid against her potential cost in terms of lost opportunity time if the attack fails. 相似文献
37.
A. E. F. Neele H. J. Nab K. M. Louwes 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1991,82(3):264-272
Summary An incomplete diallel cross was used to study components of genetic variation in potatoes for a range of characters after early and late harvest. The progenies were also used to evaluate five predictors of progeny performance, namely the mean seedling performance, the mid-parent value and the means of the selfed progenies, of the diploid progenies and of the test-cross progenies. For almost all characters, the general combining ability effects were predominant, although the specific combining ability effects present were greater at late than at early harvests. The seedling performance for tuber yield, number of tubers and average tuber weight did not show any relevant relationship to the field performance. The midparent value provided, in general, satisfactory predictions of the mean progeny performance obtained in the diallel, except for ware tuber yield. The selfed and the diploid progenies did not improve the prediction of progeny means compared to the mid-parent value. The predictions based on the test-crosses surpassed those of the mid-parent value, particularly for tuber yield at ware potato harvest. Methods to identify superior parents are discussed. 相似文献
38.
用鸡胚细胞(CEC)和Madin-Darby Canine Kidney(MDCK)两个宿主细胞系统,检查甲型流感病毒各亚型不同时期流行株的温度敏感性状(ts),发现自然界存在许多宿主依赖的温度敏感性突变株(hd-ts)。它们在CEC上是ts,在MDCK上却是ts~ 。检出的hd-ts株中有些曾经过人体接种观察证明为减毒株。这表明在CEC中鉴定的ts表型与对人减毒性状密切相关。 相似文献
39.
Host defense deficiency in newborn nonhuman primate lungs 总被引:2,自引:0,他引:2
A T Cheung G Kurland M E Miller E W Ford S A Ayin E M Walsh 《Journal of medical primatology》1986,15(1):37-47
We have investigated two major aspects of the pulmonary host defense mechanism--alveolar macrophage function as a "first line of bacterial defense" and induced neutrophil migration into the lung as a "back-up defense." Chemotactic and phagocytic/killing assays revealed a functional deficiency in the alveolar macrophages of newborn primates. Serial bronchoalveolar lavage investigations revealed diminished neutrophil migration into the newborn primate lung. The overall pulmonary host defense capability in newborn primates was deficient. The results of this investigation may have direct clinical relevance to the susceptibility of newborns to infections and pneumonia. 相似文献
40.
Habitat choice of some field-inhabiting carabid beetles (Coleoptera: Carabidae) studied by recapture of marked individuals 总被引:2,自引:0,他引:2
HENRIK WALLIN 《Ecological Entomology》1986,11(4):457-466
ABSTRACT.
- 1 Habitat choice of some field-inhabiting carabid beetles was studied in the field, and included the adult-overwintering Bembidion lampros Herbst, Pterostichus cupreus L. and Agonum dorsale Pontoppidan, and the larval-overwintering Trechus secalis Paykull, Pterostichus melanarius Illiger, P.niger Schaller and Harpalus rufipes De Geer. These were compared to the forest-inhabiting and adult-overwintering species, Carabus nemoralis Müller.
- 2 Marked beetles were released in the centre of a circular enclosure which was placed on the edge between a cereal field and a wood. The direction of movement in this circle was compared with that in a control circle placed entirely in the cereal field.
- 3 In the field/wood circle, adult-overwinterers and the larval-overwin-terer H.rufipes choose to move into the cereal field. The majority of T.secalis. P.melanarius and C.nemoralis, however, moved into the wood, while P.niger exhibited no preference.
- 4 In the field circle, adult-overwinterers moved towards the more sun-exposed parts of the circle, whereas the movements of larval-overwin-terers were random.
- 5 Some species-specific characteristics considered important for habitat choice by these carabid beetles, and the relevance of these characteristics for their dispersal behaviour are discussed.