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41.
Joseph A Sparano Peter H Wiernik Xiaoping Hu Catherine Sarta David H Henry Howard Ratech 《Cancer immunology, immunotherapy : CII》1998,15(1):50-57
Protease inhibitors are an important new class of agents for the treatment of human immunodeficiency virus (HIV) infection.
The purpose of our trial was to determine the feasibility of combining the protease inhibitor saquinavir with a 96-hour continuous
intravenous infusion of cyclophosphamide (800 mg/M2), doxorubicin (50mg/M2, and etoposide (240 mg/M2) (CDE) plus filgrastim in patients with non-Hodgkin's lymphoma associated with HIV infection. The effect of saquinavir on
CDE-induced myelosuppression, CD4 lymphopenia, and non-hematologic toxicity was also sought. Twelve patients with HIV-related
lymphoma received CDE every 28 or more days. All patients received saquinavir (600 mg PO TID), filgrastim andPneumocystis carinii and fungal prophylaxis. Patients also received either stavudine (n=2) or boths stavudine and didanosine (n=10). Toxicity was analyzed using the NCI Common Toxicity Criteria for each cycle and the data were compared with the data
from our prior study of CDE plus didanosine. An interim analysis was performed after accrual of the first 12 patients in order
to assess toxicity. Severe (grade 3 or 4) mucositis occurred in eight of 12 patients (67%) treated with CDE plus saquinavir
compared with three of 25 patients (12%) in our prior study treated with CDE without saquinavir (P<0.001). In logistic regression analysis, saquinavir use was the only factor associated with a significantly greater risk
of severe mucositis (relative risk 7.9;P=0.03). Saquinavir use was not associated with a significant difference in the incidence of febrile neutropenia, prolonged
neutropenia, chemotherapy dose reduction, or in the degree of myelosuppression. The decrease in CD4 lymphocytes for patients
treated with saquinavir (absolute decrease of 23/μL, or a 26% decrease from baseline) was significantly less than for patients
treated without saquinavir in the prior study (absolute decrease of 91/μL, or 42% decrease from baseline;P=0.05). Four of 10 patients (40%) treated with saquinavir had an increase in CD4 lymphocytes of ≥10/μL compared with none
of 25 patients (0%) treated without saquinavir (P<0.001). Combination of the protease inhibitor saquinavir with infusional CDE in patients with HIV-associated lymphoma was
associated with a significant increase in the incidence of severe mucositis. This finding suggests that saquinavir may alter
the metabolism of one of more of the cytotoxic agents in the CDE regimen, and underscores the need for careful investigation
regarding the use of the protease inhibitors in patients receiving chemotherapy. 相似文献
42.
双歧杆菌预防化疗后肠道菌群失调症的临床研究 总被引:1,自引:0,他引:1
探讨双歧杆菌对乳腺癌患者由于化疗导致肠道菌群失调的预防作用。2010年在我科住院的98例乳腺癌患者,在第一周期化疗后有48例出现肠道菌群失调,发生率为48.9%;在3周后的第二周期化疗前1d予患者口服双歧杆菌(双歧杆菌乳杆菌三联活菌片,一次4片,一日2次),直至化疗后2周,肠道菌群失调例数减少到32例,发生率为32.7%。在前后两周期化疗期间监测血常规,粪便菌群失调检查。治疗周期出现菌群失调比例32.7%明显低于对照周期48.9%(P〈0.05),双歧杆菌对乳腺癌患者化疗导致胃肠菌群失调有预防作用。 相似文献
43.
44.
The 3' part of the glucosamine-6-phosphate synthase gene from Histoplasma capsulatum was PCR amplified using degenerate primers
designed from the known glucosamine-6-phosphate synthase gene sequences, cloned and sequenced. The computer analysis of the
676 bp sequence revealed the presence of two introns. The identities of the deduced amino acid sequence to the corresponding
Saccharomyces cerevisiae and Candida albicans fragment are 65 and 63.8%, respectively.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
45.
S Basu M Khanra B Dash J Majumdar J Biswas P Chaudhuri 《Cancer immunology, immunotherapy : CII》1999,16(3):199-203
We performed a retrospective analysis on the effect of neoadjuvant chemotherapy with three cycles of methotrexate (100 mg/m2 on day 1), cisplatin (90 mg/m2 on day 1) and bleomycin (20 mg/m2 on day 1–5) with 21 d gap between each cycle in 44 patients with advanced squamous cell carcinoma of the cheek, lip and tongue
followed by surgery and adjuvant chemotherapy consisting of cisplatin (90 mg/m2 on day 1), Mitomycin C (6 mg/m2 on day 1) and 5-fluorouracil (1000 mg/m2 120 h continuous infusion from day 1) repeated every 3 weeks for three cycles.
Following induction chemotherapy, complete response was observed in 11 out of 44 patients (25%), and a partial response in
a further 28 patients (64%).
The overall median survival of all patients was 29 months and those in stage III and stage IV were 30 and 15 months respectively
(P<0.001). The median duration of the time to relapse in patients who responded to adjuvant chemotherapy was 28 months.
The main toxic effect was vomiting followed by hematological toxicity. No treatment-related deaths occurred.
The regimen showed a significant response, encouraging median survival and a good tolerability profile. 相似文献
46.
金桂云林福煌邢丽陈美丹 《现代生物医学进展》2012,12(16):3095-3097
目的:探讨宫颈癌热灌注化疗栓塞的治疗作用及对临床疗效的影响因素分析。方法:对34例宫颈癌病人进行子宫动脉热灌注化疗及栓塞术,分析肿瘤病理类型,肿块大小,周围浸润及淋巴结转移情况等因素对介入治疗的影响。结果:经过对临床疗效的多因素分析肿块大小对治疗效果影响最大,其次为病理类型。其余影响较小。结论:宫颈癌热灌注化疗栓塞术是治疗宫颈癌的一种适合疗法,尤其适用于肿块较小的病人。可以使疾病得到有效控制,增加手术机会。 相似文献
47.
Shanzhi Li Zhuoxin Li Yiquan Li Yilong Zhu Jicheng Han Wenjie Li Ningyi Jin Jinbo Fang Xiao Li Guangze Zhu 《Journal of cellular and molecular medicine》2022,26(20):5222
In this study, we compared the inhibitory effects of recombinant oncolytic adenovirus (Ad‐apoptin‐hTERTp‐E1a, Ad‐VT) with that of doxorubicin (DOX), a first‐line chemotherapy drug, and tamoxifen (TAM), an endocrine therapy drug, on the proliferation of breast cancer cells. We found that Ad‐VT could effectively inhibit the proliferation of breast cancer cells (p < 0.01); the inhibition rate of Ad‐VT on normal mammary epithelial MCF‐10A cells was less than 20%. DOX can effectively inhibit the proliferation of breast cancer cells and also has a strong inhibitory effect on MCF‐10A cells (p < 0.01). TAM also has a strong inhibitory effect on breast cancer cells, among which the oestrogen‐dependent MCF‐7 cell inhibition was stronger (p < 0.01), At higher concentrations, TAM also had a high rate of inhibition (>70%) on the proliferation of MCF‐10A cells. We also found that both recombinant adenovirus and both drugs could successfully induce tumour cell apoptosis. Further Western blot results showed that the recombinant adenovirus killed breast cancer cells through the endogenous apoptotic pathway. Analysis of the nude mouse subcutaneous breast cancer model showed that Ad‐VT significantly inhibited tumour growth (the luminescence rate of cancer cells was reduced by more than 90%) and improved the survival rate of tumour‐bearing mice (p < 0.01). Compared with DOX and TAM, Ad‐VT has a significant inhibitory effect on breast cancer cells, but almost no inhibitory effect on normal breast epithelial cells, and this inhibitory effect is mainly through the endogenous apoptotic pathway. These results indicate that Ad‐VT has significant potential as a drug for the treatment of breast cancer. 相似文献
48.
Gyetvai A Emri T Takács K Dergez T Fekete A Pesti M Pócsi I Lenkey B 《FEMS yeast research》2006,6(8):1140-1148
Lovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. Because yeast-->pseudomycelium and hyphae morphogenetic transitions took place under exposure to lovastatin morphogenetic switch and apoptotic cell death must be regulated independently in C. albicans. 相似文献
49.
Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus and the agent of paracoccidioidomycosis (PCM), which is prevalent in rural workers
of Latin American countries. Until a decade ago, most of the studies involving P. brasiliensis used clinical isolates, since environmental samples from soil are difficult to obtain. More recently, P. brasiliensis has been isolated from infected wild and domestic animals, especially from the nine-banded armadillo Dasypus novemcinctus in Brazil. Over the years, diversity within the species has been observed at several phenotypic levels. The present review
will discuss the reports focusing on genetic polymorphism, which culminated with the detection of P. brasiliensis phylogenetic species as a result of a multilocus study. Polymorphism in the PbGP43 gene is detailed. This gene encodes fungal glycoprotein gp43, a dominant P. brasiliensis antigen largely studied in the last two decades for its importance in diagnosis, immune protection, and adhesive properties
to extracellular matrix-associated proteins. Fungal traits associated with genetic groups are discussed. 相似文献
50.
Nicola Vannini Vasco Campos Mukul Girotra Vincent Trachsel Shanti Rojas-Sutterlin Josefine Tratwal Simone Ragusa Evangelos Stefanidis Dongryeol Ryu Pernille Y. Rainer Gena Nikitin Sonja Giger Terytty Y. Li Aikaterini Semilietof Aurelien Oggier Yannick Yersin Loïc Tauzin Eija Pirinen Olaia Naveiras 《Cell Stem Cell》2019,24(3):405-418.e7