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81.
Competing group members tend to arrange in a social order that governs who will likely submit to whom. In many species the spatial distribution of individuals often reflects social status: dominants tend to occupy central locations while subordinates are often found along the group's periphery. This article explores the emergence of spatial consequences as a result of social rank differentiation. Rather than orienting centripetally, the movements of crayfish (Orconectes rusticus) primarily indicated a tendency to remain close to arena walls. Spatial locations were affected by the location of group members; but, rather than actively aggregating or clustering, individuals maintained a minimum distance. Previously established social rank did not affect spatial distributions. High population densities in the field are likely attributed to habitat constraints, rather than any social or centripetal tendencies of individual crayfish. 相似文献
82.
This paper evaluates the utilisation of space by epibenthic diatom cells, as a response to environmental variations. The aggregation pattern of five species of epibenthic diatoms was quantified and compared to provide evidence for the significance of cell motility as an adaptive mechanism for space occupation and monopoly. The epibenthic diatoms included (1) non-mobile colonial species forming either fan-shaped (Synedra tabulata (Ag)Kz.) or arborescent (Gomphonema kamtschaticum var. californicum Grun.) colonies; (2) slow-moving (Cocconeis costata Greg, and Amphora pusio Cl.), and (3) fast-moving (Navicula direct a (W. Sm.) Ra.) non-colonial species. The aggregation pattern of S. tabulata did not vary significantly among six different light intensities manipulated in nature. The major patterns of aggregation were identified using analysis of covariance and dummy-variable regression. Highly mobile N. directa are significantly less aggregated than the four other diatom species. Non-mobile and slow-moving species show a similar, highly aggregated pattern. The occurrence of two patterns of spatial dispersion indicates that growth forms bear far-ranging ecological implications with respect to colonization strategies, immigration, and possibly impact by grazers. An integrated model of growth form characteristics, biological properties, and ecological implications is presented for epibenthic diatoms. 相似文献
83.
The relationship between quantitative genetics and population genetics has been studied for nearly a century, almost since the existence of these two disciplines. Here we ask to what extent quantitative genetic models in which selection is assumed to operate on a polygenic trait predict adaptive fixations that may lead to footprints in the genome (selective sweeps). We study two-locus models of stabilizing selection (with and without genetic drift) by simulations and analytically. For symmetric viability selection we find that ∼16% of the trajectories may lead to fixation if the initial allele frequencies are sampled from the neutral site-frequency spectrum and the effect sizes are uniformly distributed. However, if the population is preadapted when it undergoes an environmental change (i.e., sits in one of the equilibria of the model), the fixation probability decreases dramatically. In other two-locus models with general viabilities or an optimum shift, the proportion of adaptive fixations may increase to >24%. Similarly, genetic drift leads to a higher probability of fixation. The predictions of alternative quantitative genetics models, initial conditions, and effect-size distributions are also discussed. 相似文献
84.
Prostephanus truncatus is an economically important beetle pest of stored maize and cassava in the tropics. Male beetles signal using an aggregation pheromone that attracts both female and male beetles over large distances. Females preferentially orientate towards the pheromone signals of particular males when given a choice. The influence of pheromone signalling on courtship and mating success was investigated using pheromone biossays and mating trials in both of which a female made a choice between two males. Signalling was manipulated by exposing males to a Female Factor that inhibits pheromone production. The relative attractiveness of males to females based on pheromone bioassays was found not to influence short-range courtship behaviour or mating success. 相似文献
85.
Federica Prati Manuela Bartolini Elena Simoni Angela De Simone Antonella Pinto Vincenza Andrisano Maria Laura Bolognesi 《Bioorganic & medicinal chemistry letters》2013,23(23):6254-6258
The anti-amyloid properties shared by several quinones inspired the design of a new series of hybrids derived from the multi-target drug candidate memoquin (1). The hybrids consist of a central benzoquinone core and a fragment taken from non-steroidal anti-inflammatory drugs, connected through polyamine linkers. The new hybrids retain the potent anti-aggregating activity of the parent 1, while exhibiting micromolar AChE inhibitory activities. Remarkably, 2, 4, (R)-6 and (S)-6 were Aβ aggregation inhibitors even more potent than 1. The balanced amyloid/cholinesterase inhibitory profile is an added value that makes the present series of compounds promising leads against Alzheimer’s disease. 相似文献
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88.
Adriana Alzate Fons van der Plas Fernando A. Zapata Dries Bonte Rampal S. Etienne 《Ecology and evolution》2019,9(4):1567-1577
Dispersal is thought to be an important process determining range size, especially for species in highly spatially structured habitats, such as tropical reef fishes. Despite intensive research efforts, there is conflicting evidence about the role of dispersal in determining range size. We hypothesize that traits related to dispersal drive range sizes, but that complete and comprehensive datasets are essential for detecting relationships between species’ dispersal ability and range size. We investigate the roles of six traits affecting several stages of dispersal (adult mobility, spawning mode, pelagic larval duration (PLD), body size, aggregation behavior, and circadian activity), in explaining range size variation of reef fishes in the Tropical Eastern Pacific (TEP). All traits, except for PLD (148 species), had data for all 497 species in the region. Using a series of statistical models, we investigated which traits were associated with large range sizes, when analyzing all TEP species or only species with PLD data. Furthermore, using null models, we analyzed whether the PLD‐subset is representative of the regional species pool. Several traits affecting dispersal ability were strongly associated with range size, although these relationships could not be detected when using the PLD‐subset. Pelagic spawners (allowing for passive egg dispersal) had on average 56% larger range sizes than nonpelagic spawners. Species with medium or high adult mobility had on average a 25% or 33% larger range, respectively, than species with low mobility. Null models showed that the PLD‐subset was nonrepresentative of the regional species pool, explaining why model outcomes using the PLD‐subset differed from the ones based on the complete dataset. Our results show that in the TEP, traits affecting dispersal ability are important in explaining range size variation. Using a regionally complete dataset was crucial for detecting the theoretically expected, but so far empirically unresolved, relationship between dispersal and range size. 相似文献
89.
Charge states rather than propensity for beta-structure determine enhanced fibrillogenesis in wild-type Alzheimer's beta-amyloid peptide compared to E22Q Dutch mutant 下载免费PDF全文
Massi F Klimov D Thirumalai D Straub JE 《Protein science : a publication of the Protein Society》2002,11(7):1639-1647
The activity of the Alzheimer's amyloid beta-peptide is a sensitive function of the peptide's sequence. Increased fibril elongation rate of the E22Q Dutch mutant of the Alzheimer's amyloid beta-peptide relative to that of the wild-type peptide has been observed. The increased activity has been attributed to a larger propensity for the formation of beta structure in the monomeric E22Q mutant peptide in solution relative to the WT peptide. That hypothesis is tested using four nanosecond timescale simulations of the WT and Dutch mutant forms of the Abeta(10-35)-peptide in aqueous solution. The simulation results indicate that the propensity for formation of beta-structure is no greater in the E22Q mutant peptide than in the WT peptide. A significant measure of "flickering" of helical structure in the central hydrophobic cluster region of both the WT and mutant peptides is observed. The simulation results argue against the hypothesis that the Dutch mutation leads to a higher probability of formation of beta-structure in the monomeric peptide in aqueous solution. We propose that the greater stability of the solvated WT peptide relative to the E22Q mutant peptide leads to decreased fibril elongation rate in the former. Stability difference is due to the differing charge state of the two peptides. The other proposal leads to the prediction that the fibril elongation rates for the WT and the mutant E22Q should be similar under acid conditions. 相似文献
90.
Viorica Raluca Contu Yaichiro Kotake Takashi Toyama Katsuhiro Okuda Masatsugu Miyara Shuichiro Sakamoto Shigeyoshi Samizo Seigo Sanoh Yoshito Kumagai Shigeru Ohta 《Journal of neurochemistry》2014,130(6):826-838
Parkinson's disease (PD) is a common neurodegenerative disease, but its pathogenesis remains elusive. A mutation in ubiquitin C‐terminal hydrolase L1 (UCH‐L1) is responsible for a form of genetic PD which strongly resembles the idiopathic PD. We previously showed that 1‐(3′,4′‐dihydroxybenzyl)‐1,2,3,4‐tetrahydroisoquinoline (3′,4′DHBnTIQ) is an endogenous parkinsonism‐inducing dopamine derivative. Here, we investigated the interaction between 3′,4′DHBnTIQ and UCH‐L1 and its possible role in the pathogenesis of idiopathic PD. Our results indicate that 3′,4′DHBnTIQ binds to UCH‐L1 specifically at Cys152 in vitro. In addition, 3′,4′DHBnTIQ treatment increased the amount of UCH‐L1 in the insoluble fraction of SH‐SY5Y cells and inhibited its hydrolase activity to 60%, reducing the level of ubiquitin in the soluble fraction of SH‐SY5Y cells. Catechol‐modified UCH‐L1 as well as insoluble UCH‐L1 were detected in the midbrain of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐treated PD model mice. Structurally as well as functionally altered UCH‐L1 have been detected in the brains of patients with idiopathic PD. We suggest that conjugation of UCH‐L1 by neurotoxic endogenous compounds such as 3′,4′DHBnTIQ might play a key role in onset and progression of idiopathic PD.