荔枝蝽-寄生蜂系统数量变动模型与应用

研究荔枝蝽－寄生蜂系统的数量变动规律,得到一个差分－积分方程组及求解的递推公式,指出了公式中参数的确定方法。推导出荔枝蝽－寄生蜂系统长期演变的特性,用模型证明了人工放蜂防治荔枝蝽的优越性及滥用农药的不良后果,给出了人工放蜂的最佳次数,最佳时刻及合适的放蜂量的计算公式,导出的结论与实验结果相符。     

A sustainable sensitive spectrofluorimetric approach for the determination of the multipotent protein lactoferrin in different pharmaceuticals and infant milk formula: Compliance with greenness metrics

The current study presents the first spectrofluorimetric approach for the estimation of lactoferrin, depending on the measurement of its native fluorescence at 337 nm after excitation at 230 nm, without the need for any hazardous chemicals or reagents. It was found that the fluorescence intensity versus concentration calibration plot was linear over the concentration range of 0.1–10.0 μg/mL with quantitation and detection limits of 0.082 and 0.027 μg/mL, respectively. The method was accordingly validated according to the ICH recommendations. The developed method was applied for the estimation of lactoferrin in different dosage forms, including capsules and sachets with high percent recoveries (97.84–102.53) and low %RSD values (<1.95). Lactoferrin is one of the key nutrients in milk powder and a significant nutritional fortifier. In order to assess the quality of milk powder, it is essential to rapidly and accurately quantify the lactoferrin content of the product. Therefore, the presented study was successfully applied for the selective estimation of lactoferrin in milk powder with acceptable percent recoveries (96.45–104.92) and %RSD values (≤3.607). Finally, the green profile of the method was estimated using two assessment tools: Green Analytical Procedure Index (GAPI) and Analytical GREEnness (AGREE), which demonstrated its excellent greenness.     

The protective effect of breast feeding in relation to sudden infant death syndrome (SIDS): II. The effect of human milk and infant formula preparations on binding of Clostridium perfringens to epithelial cells

Breast feeding is known to protect an infant against gastrointestinal pathogens and epidemiological studies indicate that compared to breast fed infants, formula fed infants are at a greater risk of dying from sudden infant death syndrome (SIDS). Many SIDS infants have symptoms of gastrointestinal infections prior to death and one gastrointestinal pathogen associated with SIDS is Clostridium perfringens. Studies have found that a significantly higher number of formula fed SIDS infants have C perfringens and its enterotoxin in their faeces compared to breast fed infants. The aim of the study was to compare the effects of human milk and infant formula on binding of C perfringens to epithelial cells. Two protocols were used to assess the effect of human milk and infant formula to inhibit binding of C perfringens to epithelial cells. Binding was assessed by flow cytometry. For the in vivo protocol which more closely represents interactions on the mucosal surface, breast milk enhanced bacterial binding but infant formula caused inhibition of binding; however for the in vitro method, both human milk and infant formula resulted in consistent enhancement of binding. Flow cytometry studies indicated that enhancement of binding was due to the formation of bacterial aggregates. Lewis(a) and Lewis(b) antigens, found in both breast milk and infant formula, inhibited C. perfringens binding in a dose dependent manner. The Lewis(a) and Lewis(b) antigens in human milk and infant formula can inhibit C. perfringens binding to epithelial cells. While infant formula reduced binding of C. perfringens to epithelial cells in the experiments carried out with the in vivo protocol, the protective effects of breast feeding in relation to colonisation with C. perfringens are more likely to be due to formation of bacterial aggregates. These findings have implications for improving infant formula preparations.     

汉、回、蒙古族拇指类型、环食指长、扣手、交叉臂及惯用手的研究

作者于1996年在内蒙古调查了汉、回、蒙古族5项人类遗传学经典指标(拇指类型、环食指长、扣手、交叉臂、惯用手)。研究结果显示:(1)3个民族间拇指类型、扣手出现率存在显著性差异,交叉臂、惯用手出现率则无显著性差异,环食指长出现率蒙-汉、蒙-回间存在显著性差异;(2)拇指类型、扣手、惯用手出现率无性别间差异,环食指长出现率男女间存在显著性差异;(3)惯用手与扣手、惯用手与交叉臂间存在明显的相互关系,交叉臂与扣手之间则无关;(4)与国外人群比较,3个民族环指长出现率高,交叉臂R型出现率较高,扣手R型出现率较低,惯用手L型出现率高于印度的一些群体。 Abstract:Authors in vestigated 5 general indexes of anthrotogical genetics including pollical type,palmar digital formula,hand clasping,arm folding and handedness in Han,Hui and Mongol nationalities in 1996.The results showed as follows:(1)There were significant differences in the frequency of pollical type and hand clasping in 3 nationalities,but those of arm folding and handedness showed nosignificant difference and the frequencies of palmar digital formula between the Mongol and the Hui revealed significant difference.(2)There were no significant sexual difference in the frequency of pollical type,hand clasping and handedness while the long type (R) of ring finger revealed significant sexual difference.(3)There were obvious correlations between handedness and hand clasping,handedness and arm folding but no relation between arm folding and hand clasping.(4)In comparison with foreign ethnic groups,the 3 nationalities showed higher frequencies of long type (R) of ring finger and right-arm folding but the frequence right-hand clasping revealed slightly lower.The findings showed higher frequence of Left-Handedness than that of Indian population.     

益肾活血解毒汤治疗肾虚血瘀型颈动脉粥样硬化患者的疗效观察

摘要 目的：观察益肾活血解毒汤治疗肾虚血瘀型颈动脉粥样硬化（CAS）效果。方法：选取我院2021年8月~2023年4月收治的肾虚血瘀型CAS患者80例,随机分为观察组和对照组,各40例。两组均予以常规西医治疗,观察组加服益肾活血解毒汤,治疗周期为四周。观察两组的临床疗效、血脂等指标变化,并进行统计学比较。结果：两组治疗前中医证候积分无差异（P＞0.05）,而治疗后,观察组中医证候积分明显低于对照组（P<0.05）;观察组总有效率（97.50%）虽在数值上高于对照组（92.50%）,但并无统计学意义（P＞0.05）;相较于治疗前,两组治疗后血脂指标（CHOL、TG、LDL-C）和炎性因子（NLRP3、Caspase-1、IL-1β、IL-18）水平显著下降（P<0.05）,而观察组下降幅度更大,与对照组差异显著（P<0.05）;服药期间,两组均无明显不良反应发生。结论：常规调脂抗动脉粥样硬化联合益肾活血解毒汤治疗肾虚血瘀型CAS疗效肯定,可有效改善临床症状,调节血脂水平,控制炎症反应,且安全性良好。     

解毒化瘀汤联合刺络放血疗法对血瘀热结证寻常型银屑病患者血清炎性因子及CREB信号传导通路相关蛋白表达的影响

摘要 目的：探讨解毒化瘀汤联合刺络放血疗法对血瘀热结证寻常型银屑病患者血清炎性因子及cAMP反应元件结合蛋白（CREB）信号传导通路相关蛋白表达的影响。方法：选取2018年5月到2020年5月武警成都支队卫生队和武警四川总队医院收治的寻常型银屑病患者共80例,随机分成对照组（维A酸哈西奈德乳膏治疗）与观察组（解毒化瘀汤联合刺络放血疗法治疗）,各40例。两组均以4周为1个疗程,共治疗2个疗程。对比两组疗效、中医证候积分、血清炎性因子及CREB信号传导通路相关蛋白表达水平。结果： 观察组的临床总有效率高于对照组（P<0.05）。两组治疗后中医证候主证、次证总评分和血清白介素-17（IL-17）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）、C反应蛋白（CRP）水平以及CREB微小核糖核酸（mRNA）、PKA mRNA、P38 mRNA相对表达量均较治疗前下降,且观察组较对照组低（P<0.05）。结论：解毒化瘀汤联合刺络放血疗法治疗血瘀热结证寻常型银屑病患者,疗效显著,可有效改善临床症状,减轻机体炎性反应,其主要作用机制可能与调节CREB信号传导通路相关蛋白表达有关。     

The viscosity increment for ellipsoids of revolution. Some observations on the Simha formula

Outstanding uncertainties in the widely employed Simha (J. Phys. Chem. 44 (1940) 25) function for the viscosity increment r of macromolecules as modelled by axially symmetric ellipsoids are resolved. A simple development of the analysis also reveals an interesting relationship between nu and the translational frictional property of macromolecules.     

Selenium concentration and glutathione peroxidase activity in cow’s milk

Samples of raw or pasteurized cow’s milk and infant formula were assayed for glutathione peroxidase (GSH-Px) activity, selenium (Se), and total protein. GSH-Px activity was detected in raw milk, but not in market-pasteurized milk or infant formula. The correlation between GSH-Px activity and Se levels was significant, even when the influence of protein level was removed. This result implies a role of GSH-Px as one of biologically active forms of Se in raw milk. Absence of GSH-Px activity in pasteurized milk and infant formula result from the heating process in these productions, because the heating of raw milk gave an irreversible inactivation of GSH-Px. Both GSH-Px activity and Se levels had significant correlation with protein level, but not so when the respective influences of Se and GSH-Px levels were removed. In raw cow’s milk, Se content was 23 ng/mL and GSH-Px activity was 20 U/mL. About 12% of Se was bound to GSH-Px, and 0.003% of protein was GSH-Px. Raw milk obtained in July contained higher levels of Se, GSH-Px, and protein than that in November. Data for cow’s milk were discussed in relation to those for human milk and those in New Zealand.