全文获取类型
收费全文 | 1401篇 |
免费 | 145篇 |
国内免费 | 180篇 |
出版年
2024年 | 8篇 |
2023年 | 89篇 |
2022年 | 170篇 |
2021年 | 203篇 |
2020年 | 193篇 |
2019年 | 193篇 |
2018年 | 133篇 |
2017年 | 96篇 |
2016年 | 52篇 |
2015年 | 72篇 |
2014年 | 81篇 |
2013年 | 80篇 |
2012年 | 46篇 |
2011年 | 51篇 |
2010年 | 30篇 |
2009年 | 28篇 |
2008年 | 37篇 |
2007年 | 41篇 |
2006年 | 31篇 |
2005年 | 20篇 |
2004年 | 17篇 |
2003年 | 12篇 |
2002年 | 8篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有1726条查询结果,搜索用时 203 毫秒
991.
《基因组蛋白质组与生物信息学报(英文版)》2022,20(2):382-393
Fecal microbiota transplantation (FMT) of human fecal samples into germ-free (GF) mice is useful for establishing causal relationships between the gut microbiota and human phenotypes. However, due to the intrinsic differences between human and mouse intestines and the different diets of the two organisms, it may not be possible to replicate human phenotypes in mice through FMT; similarly, treatments that are effective in mouse models may not be effective in humans. In this study, we aimed to identify human gut microbes that undergo significant and consistent changes (i.e., in relative abundances) after transplantation into GF mice in multiple experimental settings. We collected 16S rDNA-seq data from four published studies and analyzed the gut microbiota profiles from 1713 human–mouse pairs. Strikingly, on average, we found that only 47% of the human gut microbes could be re-established in mice at the species level, among which more than 1/3 underwent significant changes (referred to as “variable taxa”). Most of the human gut microbes that underwent significant changes were consistent across multiple human–mouse pairs and experimental settings. Consequently, about 1/3 of human samples changed their enterotypes, i.e., significant changes in their leading species after FMT. Mice fed with a controlled diet showed a lower enterotype change rate (23.5%) than those fed with a noncontrolled diet (49.0%), suggesting a possible solution for rescue. Most of the variable taxa have been reported to be implicated in human diseases, with some recognized as the causative species. Our results highlight the challenges of using a mouse model to replicate human gut microbiota-associated phenotypes, provide useful information for researchers using mice in gut microbiota studies, and call for additional validations after FMT. An online database named FMT-DB is publicly available at http://fmt2mice.humangut.info/#/. 相似文献
992.
993.
994.
995.
Vandna Singh Shruti Ahlawat Hari Mohan Sarvajeet Singh Gill Krishna Kant Sharma 《Journal of applied microbiology》2022,132(6):4112-4129
Reactive oxygen species (ROS; free radical form O2•−, superoxide radical; OH•, hydroxyl radical; ROO•, peroxyl; RO•, alkoxyl and non-radical form 1O2, singlet oxygen; H2O2, hydrogen peroxide) are inevitable companions of aerobic life with crucial role in gut health. But, overwhelming production of ROS can cause serious damage to biomolecules. In this review, we have discussed several sources of ROS production that can be beneficial or dangerous to the human gut. Micro-organisms, organelles and enzymes play crucial role in ROS generation, where NOX1 is the main intestinal enzyme, which produce ROS in the intestine epithelial cells. Previous studies have reported that probiotics play significant role in gut homeostasis by checking the ROS generation, maintaining the antioxidant level, immune system and barrier protection. With current knowledge, we have critically analysed the available literature and presented the outcome in the form of bubble maps to suggest that the probiotics help in controlling the ROS-specific intestinal diseases, such as inflammatory bowel disease (IBD) and colon cancer. Finally, it has been concluded that rebooting of the gut microbiota with probiotics, postbiotics or faecal microbiota transplantation (FMT) can have crucial implications in the structuring of gut communities for the personalized management of the gastrointestinal (GI) diseases. 相似文献
996.
997.
998.
999.