Aquatic Habits and Niche Partitioning in the Extraordinarily Long-Necked Triassic Reptile Tanystropheus

1. Download : Download high-res image (278KB)
2. Download : Download full-size image

     

高血压患者饮食习惯、传统制剂服用现状调查及其影响因素分析

目的:调查高血压患者饮食习惯以及传统制剂服用现状,并分析饮食习惯与高血压患病的关系以及传统制剂服用的影响因素。方法:按照简单随机抽样法,采用自制调查问卷对呼和浩特市3个镇共8个行政村成年常住农村村民进行问卷调查,调查内容包括人口学特征、饮食习惯等内容,并采用多因素logistic回归分析饮食习惯与高血压患病的关系以及高血压患者传统制剂服用的影响因素。结果:呼和浩特市高血压患病率为22.68%。多因素logistic回归结果显示,较高的BMI、高血压家族史、饮酒史、泡菜咸菜、油炸食品、红肉(猪/牛/羊肉)/动物内脏、海产品是高血压独立危险因素(OR=1.257、1.451、1.358、1.317、1.108、1.146、1.373,P<0.05),奶制品、豆制品、新鲜果蔬是高血压保护因素(OR=0.797、0.868、0.903,P<0.05)。高血压患者传统制剂服用率为16.90%。多因素logistic回归结果显示,年龄≥60岁、文化程度高中以下、不了解高血压知识是高血压患者传统制剂服用的危险因素(OR=1.342、1.545、1.142,P<0.05)。结论:呼和浩特市农村成年村民高血压患病率较高,不良饮食习惯(饮食偏咸、油腻等)是高血压独立危险因素,高龄、文化程度低、不了解高血压知识的高血压患者传统制剂服用率较高,应加强农村居民合理膳食、保持均衡饮食习惯的宣传教育以及农村高血压患者用药规范。     

Unremitting progresses for phosphoprotein synthesis

Phosphorylation, one of the important protein post-translational modifications, is involved in many essential cellular processes. Site-specifical and homogeneous phosphoproteins can be used as probes for elucidating the protein phosphorylation network and as potential therapeutics for interfering their involved biological events. However, the generation of phosphoproteins has been challenging owing to the limitation of chemical synthesis and protein expression systems. Despite the pioneering discoveries in phosphoprotein synthesis, over the past decade, great progresses in this field have also been made to promote the biofunctional exploration of protein phosphorylation largely. Therefore, in this review, we mainly summarize recent advances in phosphoprotein synthesis, which includes five sections: 1) synthesis of the nonhydrolyzable phosphorylated amino acid mimetic building blocks, 2) chemical total and semisynthesis strategy, 3) in-cell and in vitro genetic code expansion strategy, 4) the late-stage modification strategy, 5) nonoxygen phosphoprotein synthesis.