红金消结胶囊联合米非司酮治疗子宫肌瘤的疗效及对血清Ang-2、EGF、NF-κBp65水平的影响

目的:探讨红金消结胶囊联合米非司酮治疗子宫肌瘤的疗效及对血清血管生成素-2(Ang-2)、表皮生长因子(EGF)、核因子-κBp65(NF-κBp65)水平的影响。方法:选择我院2017年5月至2018年5月接诊的103例子宫肌瘤患者,通过随机数表法将其分为观察组53例和对照组50例。对照组给予米非司酮治疗,观察组在对照组基础上联合红金消结胶囊治疗,两组患者在月经期间停药,均连续治疗3个月。比较两组的临床疗效、治疗前后血清Ang-2、EGF、NF-κBp65、卵泡雌激素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平、子宫体积与瘤体情况的变化及不良反应的发生情况。结果:治疗后,观察组临床疗效总有效率为94.34%,显著高于对照组78%,P0.05),血清Ang-2、EGF、NF-κBp65、FSH、LH、E2水平均显著低于对照组(P0.05),子宫体积和子宫肌瘤体积均小于对照组(P0.05)。两组不良反应发生率比较差异无统计学意义(P0.05)。结论:红金消结胶囊联合米非司酮治疗子宫肌瘤的临床疗效显著优于单用米非司酮治疗,其可更显著改善患者性激素水平,缩小子宫和子宫肌瘤的体积,这可能与降低血清Ang-2、EGF、NF-κBp65水平有关。     

阿托伐他汀联合参松养心胶囊治疗老年心力衰竭患者临床疗效及安全性研究

目的:探讨阿托伐他汀联合参松养心胶囊对老年心力衰竭患者的临床疗效及安全性。方法:选取我院心血管内科治疗的老年慢性心力衰竭患者121例,按治疗药物不同分为两组,对照组46例采用西医常规治疗,研究组75例常规治疗基础上给予阿托伐他汀联合参松养心胶囊治疗,记录两组12个月后的临床疗效,治疗后3、6及12个月后的总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)水平的变化及不良反应的发生情况。结果:与治疗3个月时相比,两组治疗12个月时临床有效率均显著提高,研究组治疗6、12个月后临床有效率均显著高于对照组(85.33%vs. 76.09%, 88%vs. 80.43%,P0.05)。两组治疗后血清TC、TG、LDL-C水平逐步下降,血清HDL-C水平逐步上升,研究组治疗第12月后血清TC、TG及LDL-C水平较对照组显著降低(P0.05),血清HDL-C水平较对照组明显升高(P0.05)。两组在1年观察期内均未见明显肝肾功能损伤及肌溶解,不良反应发生率比较差异无统计学意义(P0.05)。结论:长期使用阿托伐他汀联合参松养心胶囊治疗老年性心力衰竭的临床效果明显优于西医常规治疗,其可有效降低血脂水平,安全性高。     

01群与非01群0139型霍乱弧菌毒力的对比研究

非０１群０１３９型霍乱弧菌是近年引起南亚次大陆霍乱流行的新型病原体,将其与０１群霍乱弧菌的毒力特性进行对比研究对于了解其特性及研制相关的菌苗具有重要意义。本文报告了４株０１３９型霍乱弧菌与０１群霍乱弧菌菌株的对比测定结果。发现０１３９型霍乱弧菌与０１群霍乱弧菌有所不同,呈不透明的菌落形态,光学显微镜及电子显微镜检显示有荚膜的表型,在体内具有较高的繁殖能力并产生肠毒素,体内侵袭试验结果表明所有４株０     

Protection against haemorrhagic septicaemia induced by vaccination of buffalo calves with an improved oil adjuvant vaccine

An experimental oil adjuvant vaccine was developed against haemorrhagic septicaemia, a disease of cattle and buffalo caused by Pasteurella multocida serotype B and E. Mineral oil, Mercol 52, was used as adjuvant together with Span 85 and Tween 85 as emulsifiers. The vaccine was evaluated by single dose intramuscular immunisation of 1–2 year old buffalo calves. IgG and IgM class antibodies were determined by ELISA. The group of animals immunised with the experimental oil adjuvant vaccine showed a high titre of the IgG class of antibodies measured at 300 days post vaccination. To compare the protective efficacy of the vaccine with the commonly used broth bacterin, another group of buffalo calves was immunised by broth bacterin. This group showed a low level of IgG antibodies. Protection was assessed by challenge with 10⁹ viable bacteria of P. multocida type B:2,5 administered subcutaneously, 250 days post vaccination. Animals vaccinated with the experimental oil adjuvant vaccine were fully protected. The other groups of animals, vaccinated with broth bacterin or used as control (non-vaccinated), developed symptoms of haemorrhagic septicaemia. A strong relationship between IgG but not IgM class antibody level and resistance to challenge was observed. The experiment demonstrated that the experimental oil adjuvant vaccine was superior to broth bacterin in providing protection against experimental haemorrhagic septicaemia in young buffalo calves beyond 250 days.     

ENCAPSULATION OF EGGS BY MARINE GASTROPODS: EFFECT OF VARIATION IN CAPSULE FORM ON THE VULNERABILITY OF EMBRYOS TO PREDATION

Representatives of many plant and animal taxa enclose their embryos within some form of protective structure. Inter- and intraspecific differences in the morphology of these egg coverings may have profound effects on the development and survival of encapsulated embryos, yet in many taxa little is known about the causes or potential consequences of this variation. Comparisons of capsule morphology among populations of the rocky shore gastropod, Nucella emarginata, revealed significant variation in the thickness of capsule walls, the only barrier separating developing embryos from the external environment. Laboratory experiments demonstrated that thicker-walled capsules were more resistant to predation by a co-occurring isopod, Gnorimosphaeroma oregonense, than were thinner-walled capsules. Control experiments confirmed that these differences in vulnerability were not caused by differences in the palatability of the capsule wall or attractiveness of the capsule contents. The actual mechanism by which thick-walled capsules differentially protect developing embryos remains unclear, although decreased vulnerability of thick-walled capsules to these isopods may simply result from increased handling time by predators. Subtle differences in capsule morphology thus appear to have substantial effects on the survival of encapsulated embryos. Hence, predators may have played an important role in selecting for the production of thick-walled capsules among populations of N. emarginata.     

Oogenesis in the malaria mosquito Anopheles gambiae

Summary Oogenesis has been followed with the electron microscope in 2 strains of the malaria mosquito Anopheles gambiae, from the emergence of the adult (oocytes at leptonema) till shortly before the oocytes are ready for oviposition. After pachynema the chromosomes form a karyosphere and a fibrous capsule develops around it. Work on other mosquitoes suggests that the capsule may be related to the synaptonemal complexes. Both Anopheles strains contain at some time an extrachromosomal (not DNA-containing) body comparable to the karyosphere in size. Clusters of granules are present at the surface of the nucleolus and free in the nucleoplasm. Tentative results indicate that they may contain DNA. During oogenesis the nucleolus becomes very large, mainly because of proliferation of the nucleolonema. Towards the end of oocyte development the nucleus assumes the large canoe-shape also seen in Aedes and Culex. Nucleolonema traverse the entire nucleus, and modified granular clusters are found throughout.     

Notes on the capsule dehiscence inAcanthophyllum (Caryophyllaceae) and allied genera

The shape and the mode of dehiscence of the capsule had been regarded as good differential characters betweenAcanthophyllum and related genera.—Studies of these characters, including the shape of the ovary, in species ofAcanthophyllum, Diaphanoptera, Ochotonophila andScleranthopsis show, however, that they cannot be used as differential characters for the genusAcanthophyllum. Dedicated to Prof.K. H. Rechinger on the occasion of his 80th birthday.     

芪苈强心胶囊联合左卡尼汀注射液对慢性心力衰竭的疗效探讨

摘要 目的：研究芪苈强心胶囊联合左卡尼汀注射液对慢性心力衰竭的疗效。方法：选择2016年1月～2019年1月我院收治的85例慢性心力衰竭患者,随机分为两组。对照组静脉滴注左卡尼汀注射液,观察组联合口服芪苈强心胶囊。检测两组治疗前后的心功能、心室重构、血浆脑钠素 N 端前体肽(N-terminal pro peptide of brain natriuretic peptide,NT-pro BNP)、高敏 C 反应蛋白(High sensitive C-reactive protein,hs-CRP)水平。结果：观察组治疗的总有效率为88.09 %（37/42）,明显高于对照组的67.44%（29/43）(P<0.05)。治疗前,两组的左心室舒张末期内径（End diastolic diameter of left ventricle,LVEDd）、心率（heart rate,HR）、左心室收缩末内径（Left ventricular end systolic diameter,LVESd）、左室射血分数（Left ventricular ejection fraction,LVEF）、心排血量（Cardiac output,CO）和E峰/A峰的比值（E peak /A peak,E/A）均无显著差异（P>0.05）;治疗后,两组的LVEDd、HR和LVESd均明显降低(P<0.05),LVEF、CO和E/A均明显升高(P<0.05),且观察组上述指标明显优于对照组(P<0.05)。治疗前,两组的血浆NT- pro BNP、hs- CRP水平比较无差异（P>0.05）;治疗后,两组的血浆NT- pro BNP、hs- CRP水平均明显降低（P<0.05）,且观察组明显低于对照组（P<0.05）。对照组发生胃肠道反应3例,头痛3例,不良反应的发生率为13.95 %;观察组发生胃肠道反应4例,头痛3例,不良反应的发生率为16.67 %。两组不良发应的发生情况无统计学意义（P>0.05）。结论：芪苈强心胶囊联合左卡尼汀注射液能改善慢性心力衰竭患者的心室重构及心功能,降低炎症标志物和神经内分泌激素水平,值得进行推广。     

超声造影对甲状腺癌包膜侵犯、淋巴结转移诊断价值及其与血清HMGB-1、sIL-2R相关性研究

摘要 目的：探讨超声造影对甲状腺癌包膜侵犯、淋巴结转移的诊断价值及其与血清高迁移率族蛋白1（HMGB-1）、可溶性白细胞介素-2受体（sIL-2R）相关性研究。方法：选取2019年2月至2020年8月本院收治的156例甲状腺结节患者作为研究对象。所有患者均经病理证实,根据病理结果提示包膜侵犯情况可分为侵犯组（86例,55.13%）与未侵犯组（70例,44.87%）;另外根据病理结果提示淋巴结转移情况也分为转移组（92例,58.97%）与未转移组（64例,41.03%）。术前均行常规超声、超声造影以及血清HMGB-1、sIL-2R水平检测。比较常规超声、超声造影诊断甲状腺包膜侵犯、淋巴结转移的诊断效能,并分析其与血清HMGB-1、sIL-2R水平的相关性。结果：常规超声、超声造影对甲状腺癌包膜侵犯、淋巴结转移的诊断结果差异均具有统计学意义（P<0.05）。超声造影诊断甲状腺癌包膜侵犯的准确性、敏感度显著高于常规超声（P<0.05）,而两种检查方式之间特异度、阳性预测值以及阴性预测值的差异无统计学意义（P>0.05）;超声造影诊断甲状腺癌淋巴结转移的准确性、敏感度、特异度、阳性预测值以及阴性预测值均显著高于常规超声（P<0.05）。甲状腺癌包膜侵犯组、淋巴结转移组的血清HMGB-1、sIL-2R水平分别显著高于未侵犯组、未转移组（P<0.05）。结论：超声造影对甲状腺癌包膜侵犯、淋巴结转移具有一定诊断价值,而与血清HMGB1、sIL-2R水平具有相关性。因此,术前行超声造影检查以及血清HMGB1、sIL-2R水平检测对甲状腺癌患者包膜侵犯、淋巴结转移有一定提示作用,可对对临床治疗方案的选择具有重要价值。     

血脂康胶囊对冠心病患者的抗氧化及抗炎效果研究

目的:探讨血脂康胶囊对冠心病患者的抗氧化及抗炎效果和意义。方法:选取冠心病并且有一定程度的脂代谢紊乱的患者64例,按随机对照原则随机分为A组(32例)及B组(32例),A组给予血脂康胶囊600mg,日2次;B组予洛伐他汀40mg/d,丙氨酸转氨酶或天冬氨酸转氨酶升高超过正常值3倍以上的患者服用剂量减半,即洛伐他汀20mg/d,经治疗或者观察恢复正常后再加到40mg/d。共比8周,检测实验前后的血浆ALT,AST,CK,OX-LDL,CRP及SOD水平。结果:血脂康胶囊可以明显的降低血浆TG,CHOL,LDL水平,并且与对照组差异有显著性意义(P<0.05)。血脂康胶囊可以明显的降低血浆OX-LD,CRP水平,与对照组差异有非常显著性意义(P<0.01),血脂康胶囊可以提高血浆SOD水平优于对照组(P<0.01),而升高ALT,AST,CK的副作用较对照组低(P<0.05)。结论:血脂康胶囊常规剂量不仅有效调脂而安全,并且有一定的抗氧化及抗炎效果。