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631.
Wulf Hildebrandt Jochen Herrmann Jürgen Stegemann 《European journal of applied physiology and occupational physiology》1994,69(2):127-131
This study evaluated the postural vascular adjustment in the human forearm which may be responsible for the recent observation that transcapillary fluid balance is maintained above the level of the heart while blood flow decreases in a linear fashion. In this study further evidence was provided that a posturally graded profile of collapsed veins holds for both an overall increase of resistance with height and compensation for hydrostatic effects on capillary pressure. This was achieved by manipulating peripheral venous profile/volume: a proximal outlet resistance (upper arm cuff) was used for re-opening of collapsed distal veins. In test (a), 12 healthy subjects underwent recordings of fluid reabsorption rate and blood flow in a 20-cm segment of their forearm horizontally placed at 36 cm above heart level (third intercostal space). Applying upper arm cuff pressures randomly between 0 and 25 mmHg (0–3.33 kPa) for 15 min led to maxima of blood flow and reabsorption rates at inflations of 5 or 10 mmHg (0.67 or 1.33 kPa). This was attributed to minima in postcapillary resistance facilitating flow and reducing capillary pressure. In test (b) the flow-maximizing outlet resistance found was studied for its effect in different forearm positions (–18, 0, 18, 36, 54 cm relative to heart level). Blood flow then showed a shift of its maximum from heart level to 36 cm above heart level, while the reabsorption rate increased above 18-cm height - in contrast to previous findings with a free circulation. It was therefore concluded that the venous profile in the forearm adjusts postcapillary resistance in such a way that local dehydration is confined at the cost of blood supply. Thicker and less collapsable veins may ensure better flow autoregulation during impaired fluid balance — as seen in the legs. 相似文献
632.
633.
Dr. Yuri V. Panchin Pavel V. Zelenin Lyudmila B. Popova 《Invertebrate neuroscience : IN》1997,3(1):27-40
The neural network underlying rhythmic wing movements in the molluscClione limacina is well-studied. Two different groups of motoneurons innervate two distinct groups of wing muscles. The locomotor rhythm
generated in the left and right pedal ganglia is synchronized by interneurons. When the axons of the locomotor motoneurons
are crushed, numerous fine neurites sprout towards the denervated muscles and reach them in 8–15 days. At this stage motoneurons
project to and synapse on not only correct but equally incorrect muscle targets. After 2 weeks of regeneration the number
of incorrect neurites and synaptic connections begins to decrease and following 1.5–2 months all incorrect connections are
eliminated, incorrect axons are withdrawn and the behavioral deficit is compensated. In this study the regeneration of interneurons
and the growth profiles of inter- and motoneurons were also studiedin vitro. Two individually isolated pedal ganglia were co-cultured in three different configurations: a) the wing nerve stump from
one ganglion was fixed against the commissural stump from another ganglion; b) the wing nerve stumps were fixed against each
other; c) the commissural stumps were fixed against each other. Under the above experimental conditions we found that the
interneurons were able to cross only the contact between two commissural stumps, and in this case found their original targets,
restored correct connections and synchronized the rhythm in two pedal ganglia. In contrast, motoneurons were able to cross
all types of contacts. 相似文献