双歧杆菌复合制剂对脂质代谢的影响

本实验观察了双歧杆菌复合制剂（三株口服液）对高脂血症患者脂质代谢的影响。结果表明,用药第２周血清胆固醇和甘油三酯即开始下降,４周效果明显（Ｐ＜０．０５）,同时高密度脂蛋白也逐渐上升。它说明三株口服液确有改善脂质代谢紊乱的作用。     

重庆市正常人群肠道双歧杆菌的定量调查

本文介绍了一种双歧杆菌的选择鉴别培养基,并用该培养基对重庆市正常人群肠道双歧杆菌进行了定量分析,进而确定了正常值,为进一步研究双歧杆菌与人类的健康和疾病以及生态学防治提供了科学依据。同时也显示了正常人类肠道中双歧杆菌的含量与年龄及性别无显著差异。     

青春型双歧杆菌对肿瘤红细胞免疫花环的促进作用

本文应用青春型双歧杆菌对艾氏腹水瘤小鼠腹腔接种,经用肿瘤红细胞花环作为检测指标,结果实验组与对照组有显著差别(经方差分析F值=5.5 P<0.01)。从这一结果可初步判断双歧杆菌可以经旁路激活补体及促进红细胞的免疫功能,进而达到抗肿瘤作用。     

双歧杆菌对门静脉血内毒素影响初步研究

本实验以大鼠为动物模型,探讨在肠道微生态失调的状态下,用大量双歧杆菌(Bifidobacteria)灌服,借以拮抗外源性需氧革兰氏阴性杆菌的生长繁殖,从而使肠源性内毒素自门静脉的吸收减少。对正常鼠、脱污染鼠、再污染鼠、治疗鼠和非治疗鼠,进行不同肠段的双歧杆菌、需氧革兰氏阴性杆菌的测定和门静脉血内毒素测定。结果表明:双歧杆菌对肠道需氧革兰氏阴性杆菌的生长繁殖,具有明显的生物拮抗作用,同时伴有相应的门静脉血内毒素水平的降低。     

Ferrous iron uptake byBifidobacterium breve

Bifidobacterium breve transports ferrous iron in preference to the ferric form in a saturable, concentration-dependent manner with an optimum pH of 6. Iron transport is highly temperature sensitive. Two transport systems with apparent Km's of 86 +/- 27 and 35 +/- 20 microM (p greater than 0.01) were distinguished, one operating at high iron concentrations, the other at low iron concentrations. Iron uptake could not be accounted for by surface binding. Uptake of iron was inhibited by iron chelators, a protein ionophore, and ATPase inhibitors, and it was stimulated by potassium ionophores. The presence of a ferri reductase in the insoluble cell fraction of B. breve and its "spent" growth medium was demonstrated. The hypothesis is presented that iron uptake by bifidobacteria is related to the nutritional immunity phenomenon.     

藻类中多糖对双歧杆菌的促生长作用

目的 探讨藻类中提取多糖对双歧杆菌的促生长作用。方法 以时间和多糖浓度为影响因素，了解不同藻类中多糖对双歧杆菌的促生长作用，对其量效关系进行分析。结果 温度在37℃，多糖浓度在0％～2％，双歧杆菌数随多糖浓度的增加而上升；多糖浓度继续升高，则反而下降。结论 不同藻类中多糖在一定浓度下能很好地促进双歧杆菌生长。     

A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning

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