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131.
132.
《Cell reports》2023,42(7):112686
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133.
Buccal mucosal smears of 100 female patients of carcinoma of breast were compared with 100 controls matched accordingly. The frequency of Barr bodies was significantly lower in carcinoma of breast patients (menstruating and menopausal women) P < 0.001 when compared with controls indicating reactivation of the inactive X chromosome. 相似文献
134.
《Journal of molecular biology》2022,434(5):167403
COVID-19 caused by SARS-CoV-2 is the latest pandemic which has thrown the world into an unprecedented social and economic uncertainties along with huge loss to humanity. Identification of the host factors regulating the replication of SARS-CoV-2 in human host may help in the development of novel anti-viral therapies to combat the viral infection and spread. Recently, some research groups used genome-wide CRISPR/Cas screening to identify the host factors critical for the SARS-CoV-2 replication and infection. A comparative analysis of these significant host factors (p < 0.05) identified fifteen proteins common in these studies. Apart from ACE2 (receptor for SARS-CoV-2 attachment), other common host factors were CSNK2B, GDI2, SLC35B2, DDX51, VPS26A, ARPP-19, C1QTNF7, ALG6, LIMA1, COG3, COG8, BCOR, LRRN2 and TLR9. Additionally, viral interactome of these host factors revealed that many of them were associated with several SARS-CoV-2 proteins as well. Interestingly, some of these host factors have already been shown to be critical for the pathogenesis of other viruses suggesting their crucial role in virus-host interactions. Here, we review the functions of these host factors and their role in other diseases with special emphasis on viral diseases. 相似文献
135.
In their attempts to evade the host immune response, mammalian viruses have evolved a wide range of strategies. These include the expression and modification of various host cytokines and receptors. Understanding the mechanism of action of these virally encoded proteins will clearly deepen our insights into immunology. In the past few months several new virally encoded chemokines have been described which can modify both the host immune and antiviral response. Their manipulation of the cytokine structure-function relationship may also be useful in the development of reagents for treating immune and proliferative diseases. 相似文献
136.
In the past year, a number of human gene therapy trials involving the adoptive transfer of genetically modified T lymphocytes have been reported. These include trials of adenosine deaminase gene transfer in children with severe combined immunodeficiency syndrome, a gene-marking study of Epstein—Barr virus-specific cytotoxic T cells, and trials of gene-modified T cells expressing suicide or viral resistance genes in patients infected with HIV. Additional strategies for T-cell gene therapy currently being pursued in the clinic involve the engineering of novel T-cell receptors that impart antigen specificity for virally infected or malignant cells. 相似文献
137.
138.
Nasopharyngeal carcinoma (NpC) is a malignant disease associated with Epstein-Barr virus infection, and often diagnosed at an
advanced stage. This significantly curtails patient survival. We hypothesize that a panel of biomarkers can be assembled to assess
NpC incidence, early detection, and tumor progression during therapeutic intervention. Our thesis rests on a model of
successfully predicting high-risk gliomas by means of a carefully crafted panel of molecular mitotic biomarkers (i.e., securin,
survivin and MCM2). The strategy we propose holds strong promise for prevention and cure of NpC. The approach we propose
seeks to identify certain biomarkers from viral materials, patient tissues and assessment of related diseases, whose signatures,
taken together, will be endowed with some degree of congruency, or sense of a coordinated language (i.e., “votes”). Biomarker
“voting” will then permit to outline a broad coordinated molecular map for the molecular and epigenetic characterization of each
individual patient''s NpC tumor. We will draw on the process of contrasting biomarkers in health and disease, which rests on the
auto-proteomic concept particularly relevant in high-risk cancer individuals, such as is the case for NpC. In brief we defend,
current advances in human proteome profiling proffers the possibility of having individual baseline proteomic profiles using local
body fluids (e.g., saliva, nasal secretions, sputum) or systemic fluids (e.g., plasma, serum, cerebrospinal fluid) to unravel a
personalized molecular map for high-risk NpC individuals. Regular check-up will monitor for new or impending manifestations
of NpC, and provide a secure assessment of incidence and early detection. 相似文献
139.
TianLiang Xia Xingyang Li Xueping Wang YunJia Zhu Hua Zhang Weisheng Cheng MeiLing Chen Ying Ye Yan Li Ao Zhang DanLing Dai QianYing Zhu Li Yuan Jian Zheng Huilin Huang SiQi Chen ZhiWen Xiao HongBo Wang Gaurab Roy Qian Zhong Dongxin Lin YiXin Zeng Jinkai Wang Bo Zhao Benjamin E Gewurz Jianjun Chen Zhixiang Zuo MuSheng Zeng 《EMBO reports》2021,22(4)
140.
Lei-Lei Yuan Chang-Mi Deng Wen-Qiong Xue Yong-Qiao He Tong-Min Wang Jiang-Bo Zhang Da-Wei Yang Ting Zhou Zi-Yi Wu Ying Liao Mei-Qi Zheng Dan-Hua Li Lian-Jing Cao Yi-Jing Jia Wen-Li Zhang Ruo-Wen Xiao Lu-Ting Luo Xia-Ting Tong Yan-Xia Wu Jing-Wen Huang Wei-Hua Jia 《The journal of gene medicine》2021,23(11):e3375