排序方式: 共有17条查询结果,搜索用时 31 毫秒
11.
Kristopher R. Genschmer Derek W. Russell Charitharth Lal Tomasz Szul Preston E. Bratcher Brett D. Noerager Mojtaba Abdul Roda Xin Xu Gabriel Rezonzew Liliana Viera Brian S. Dobosh Camilla Margaroli Tarek H. Abdalla Robert W. King Carmel M. McNicholas J. Michael Wells Mark T. Dransfield Rabindra Tirouvanziam J. Edwin Blalock 《Cell》2019,176(1-2):113-126.e15
12.
13.
14.
Mitochondrial dysfunctions are a known pathogenetic mechanism of a number of neurological and psychiatric disorders. At the same time, mutations in genes encoding for components of the mitochondrial respiratory chain cause mitochondrial diseases, which commonly exhibit neurological symptoms. Mitochondria are therefore critical for the functionality of the human nervous system. The importance of mitochondria stems from their key roles in cellular metabolism, calcium handling, redox and protein homeostasis, and overall cellular homeostasis through their dynamic network. Here, we describe how the use of pluripotent stem cells (PSCs) may help in addressing the physiological and pathological relevance of mitochondria for the human nervous system. PSCs allow the generation of patient-derived neurons and glia and the identification of gene-specific and mutation-specific cellular phenotypes via genome engineering approaches. We discuss the recent advances in PSC-based modeling of brain diseases and the current challenges of the field. We anticipate that the careful use of PSCs will improve our understanding of the impact of mitochondria in neurological and psychiatric disorders and the search for effective therapeutic avenues. 相似文献
15.
16.
《Endocrine practice》2021,27(6):626-635
IntroductionObesity is a chronic illness that requires a multifaceted personalized treatment approach.Methods & FindingsUsing current guidelines and recent studies in weight management, this article reviews the multiple components of weight management: lifestyle intervention (dietary intervention, physical activity, and behavioral interventions), pharmacotherapy, endoscopic procedures, and surgical procedures. This review briefly discusses specific diets and dietary strategies, compensatory mechanisms acting against weight loss, recent changes to Food and Drug Administration approved antiobesity medications, and technological advances in weight management delivery.ConclusionCurrent literature is lacking large studies on the safety and efficacy of combination therapies involving pharmacotherapy plus 1 or more procedures. 相似文献
17.